Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Evolutionary Perspectives on Aging
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"Building Haystacks and Finding Needles in the Genomics of Ageing"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Why Live Longer on Less and Why the Sexes Age Differently"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Evolvable Soma Theory: Redefining the Role of Evolution in Ageing"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Infectious Diseases-Driven Evolution of Life Histories in Eusocial Species"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"The Evolution of Asymmetrical Regulation of Physiology is Central to Aging"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Invertebrate Models of Aging
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Improving DNA Double-Strand Break Repair to Extend the Mitotic Lifespan"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Disequilibrium in Organismal mRNA Content During Aging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Powerful Genetic Dissection of Lifespan Variation in Drosophila melanogaster "
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Genetics, Genomics, and Metabolomics of Exceptional Longevity and Its Variation in the World's Longest-Lived Animal"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Environmental Exposures and Aging: Wildfire Smoke and Microplastic Exposure"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Aging Without Degeneration: Transcriptional Reallocation Supports Nervous System Maintenance in a Non-senescent Invertebrate Model"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mechanisms of Parental Reproductive Aging on Cell Division During Early Embryogenesis in Offspring"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hypothermia and the Control of Senescence"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vertebrate Models of Aging
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Population Size Shapes the Evolution of Lifespan"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"A Comparative Approach to Uncover the Mechanisms of Bats’ Extended Healthspans"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Age-Resilient Epigenetic Landscapes in the Axolotl"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Sterilization and Contraception Increase Lifespan across Vertebrates"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Proteomics of Meiotic Rejuvenation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome, Epigenome and Chromatin
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"The Network Effect: How Protein Networks Control DNA Repair and Shape Cellular Aging"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"DNA Damage and Systemic Aging: The Connection with Nutrition, Gene size, Transcription stress and Neurodegeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Somatic Mutation, Genome Mosaicism, and Aging"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Recombinant Zoster Vaccination in Patients With Dementia Is Associated With Improved Survival and Better Cognitive Preservation"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Cell-Type Specific Disease Scoring in Alzheimer's Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"The Polaris Platform for Omics and Longevity AI-Assisted Research Integration and Scoring"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Conserved Master Regulators Orchestrate Cellular Reprogramming-Induced Rejuvenation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Longitudinal Proteomic Profiling Reveals Mechanisms of Aging and Resilience"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Time to Eat More and Live Longer: Circadian-Regulated Gene Expression and Aging"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Biological Underpinnings of the Pattern of Human Ovarian Follicle Loss Across the Lifespan"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Aging Disrupts Spatiotemporal Coordination in the Cycling Murine Ovary"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Characterization of the Epigenetic Deterioration of Oocytes and Surrounding Granulosa Cells with Age and Their Epigenetic Artificial Rejuvenation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Protein Homeostasis in Mammalian Oocytes during Fertility and Reproductive Aging"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Systemic Control and Inter-Organ Communication of Ovarian Aging"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Systems Aging and Immunology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Biobank-Scale Genetic Epidemiology, Immunology and Aging"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Human Immune Aging is a Developmental Process with Clinical Implications"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Diverging Paths of Brain Aging: From Cellular Microenvironments to Systemic Coordination"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"A Systems Biology Approach to Hormesis"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Defining the Role of Adipose-Glucocorticoid Signaling in Age-Related Metabolic Disorders and Cellular Senescence"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Maternal Obesity and Perinatal Obesogenic Exposure Trigger Genomic Stress Responses Driving Premature Alveolar Epithelial Aging and Emphysema in life"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Aging as Complex but Interpretable Dynamical Systems"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Dormant Hypothalamic Circuits Contribute to Brain-Body Aging"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Frailty, Entropy, Energy, and Aging"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Feeding Longevity: What Animal Models and Humans Teach Us About Nutrition and Aging"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Insights into Frailty Mechanisms Using Longitudinal Mouse Studies in Both Sexes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Is Aging Simpler Than We Think? Toward Principles of Damage Accumulation"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Biomarkers and Quantitative Aging
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Strategies for Building Causal Epigenetic Clocks"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Biomarkers of Aging Consortium: Updates and Future Perspectives"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"The Aging of Molecules: From DNA to Proteins"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Measuring Aging at Scale"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Responsive and Reliable Biomarkers of Aging: Rebuilding Epigenetic Clocks for Clinical Translation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Geroprotectors Hiding in Plain Sight: Systematic Identification of Approved Drugs that Reduce Organ-Specific Biological Age"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Metabolomic Predictions for Anti-Aging Drugs"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Face Photo-Based Measurements of Biological Age"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Using Intravital Label-Free Imaging to Characterize Age-Related Changes in Tissue Metabolism and Microstructure"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"It's a Family Affair: Identification and Characterization of Rare Protein-Altering Genetic Variants Linked to Familial Longevity"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Cellular Senescence and Human Longevity: Implications in Senotherapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Immune Health and Aging in Humans"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Metformin and Clemastine Rejuvenate Measures of DNA Methylation Age and Promote CNS Remyelination in Adults with Multiple Sclerosis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Uncovering the Mechanisms of Exceptional Longevity Through Centenarian iPSC-Based Modeling of Resiliency"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure