| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments |
| 7:40 pm - 9:30 pm | SYSTEMS BIOLOGY APPROACHES TO RNA PROCESSING |
| Discussion Leader: Don Rio (University of California, Berkeley) |
| 7:40 pm - 7:55 pm | Don Rio (University of California, Berkeley)
"Genomic Analysis of Alternative pre-mRNA Splicing in Drosophila" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:15 pm | Jason Johnson (Merck)
"Advancing mammalian transcriptome profiling and analysis" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Benjamin Blencowe (University of Toronto)
"Global regulatory features of mammalian alternative splicing" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Jack Keene (Duke University)
"Posttranscriptional RNA Operons" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | William Marzluff (University of North Carolina, Chapel Hill)
"A genome wide screen for histone pre-mRNA processing" |
| 9:15 pm - 9:20 pm | Discussion |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PRE-MRNA SPLICING: FACTORS, MECHANISMS AND HUMAN DISEASES |
| Discussion Leader: Tom Cooper (Baylor College of Medicine) |
| 9:00 am - 9:20 am | Magda Konarska (Rockefeller University)
"A two-state model for spliceosome function" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am- 9:45 am | Jonathan Staley (University of Chicago)
"Motors and Switches that Regulate the Specificity and Activity of the Spliceosome" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Charles Query (Albert Einstein College of Medicine)
"The NTC component Cef1/CDC5 modulates catalytic states of the spliceosome" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | SC Cheng (Academia Sinica, Taiwan)
"Spliceosome disassembly in yeast" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:15 am | Coffee Break |
| 11:15 am - 11:35 am | Tom Misteli (National Cancer Institute, NIH)
"Splicing of LMNA in premature and physiological aging" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12: 00 pm | Tom Cooper (Baylor College of Medicine)
"Alternative splicing in development and disease" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:25 pm | Maurice Swanson (University of Florida)
"The muscleblind knockout model for mis-regulation of alternative splicing during development" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:45 pm | Group Photo Followed by Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PRE-MRNA SPLICING AND CANCER |
| Discussion Leader: Mariano Garcia-Blanco (Duke University) |
| 7:30 pm - 7:45 pm | Robert Darnell (HHMI, Rockefeller University)
"RNA regulation in neurons and neurologic disease" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Xiangdong Fu (University of California, San Diego)
"Regulated Splicing in Development and Cancer" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Benoit Chabot (Université de Sherbrooke, Canada)
"Alternative splicing of apoptotic genes: from fine control to global regulation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Adrian Krainer (Cold Spring Harbor Laboratory)
"Oncogenic properties of SR proteins" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Mariano Garcia-Blanco (Duke University)
"Imaging splicing decisions in vivo" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Jamal Tazi (IGMM/CNRS, France)
"Alternative splicing: a novel pharmacological target with wide therapeutic potential" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ALTERNATIVE SPLICING AND ITS REGULATION |
| Discussion Leader: Timothy W. Nilsen (Case Western Reserve University) |
| 9:00 am - 9:20 am | Douglas Black (University of California, Los Angeles)
"Alternative splicing and the regulation of neuronal gene expression" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am- 9:45 am | Chris Smith (University of Cambridge, UK)
"Splicing repression by PTB" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | James Bruzik (Case Western Reserve University)
"Regulation of alternative 5' splice sites" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Woan-Yuh Tarn (Institute of Biomedical Sciences, Taiwan)
"Cell stress modulates the function of splicing regulatory factor RBM4 in mRNA metabolism" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:15 am | Coffee Break |
| 11:15 am - 11:35 am | Alberto Kornblihtt (Universidad de Buenos Aires, Argentina)
"Long distance and polar effects in alternative splicing" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Kristen Lynch (University of Texas Southwestern Medical Center)
"Alternative splicing in the immune system" |
| 12:00 pm - 12: 05 pm | Discussion |
| 12:05 pm - 12:25 pm | Javier Caceres (MRC, Western General Hospital, UK)
"Multiple roles of SR proteins in mRNA processing" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REGULATION OF RNA STABILITY |
| Discussion Leader: Lynne Maquat (University of Rochester) |
| 7:30 pm - 7:45 pm | Lynne Maquat (University of Rochester)
"Nonsense-mediated and Staufen1-mediated mRNA decay: related pathways of posttranscriptional control" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Roy Parker (HHMI, University of Arizona)
"Control of translation and mRNA degradation in eukaryotes" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Jens Lykke-Andersen (University of Colorado, Boulder)
"TTP and BRF proteins mediate the localization and degradation of ARE-containing mRNAs in processing bodies" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Christoph Moroni (Universitat Basel, Switzerland)
"Mechanism of action and role in ES cells of the ARE-dependent regulator BRF1" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Elmar Wahle (Universitaet Halle, Germany)
"mRNA turnover" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Marvin Wickens (University of Wisconsin-Madison)
"Regulating mRNAs: PAPs, PUFs and poly(A)" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSCRIPTION, SPLICING AND THE 3’ END FORMATION |
| Discussion Leader: Nicholas Proudfoot (University of Oxford) |
| 9:00 am - 9:20 am | Nicholas Proudfoot (University of Oxford)
"Interconnecting transcription, RNA processing and gene structure in eukaryotes" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | James Manley (Columbia University)
"mRNA processing and links with other nuclear events" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Robin Reed (Harvard Medical School)
"Networks of coupled interactions in gene expression" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Joel Richter (University of Massachusetts Medical School)
"CPEB-mediated 3’ end formation" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:30 am | Clinton MacDonald (Texas Tech University)
"Polyadenylation and the Control of Spermatogenesis" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Stephen Buratowski (Harvard Medical School)
"Transcription termination and RNA 3' end processing" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 am - 12:20 pm | David Brow (UW, Madison)
"Connections between transcription termination and RNA processing" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | RNP ASSEMBLY AND MRNA LOCALIZATION |
| Discussion Leader: Reinhard Lührmann (Max Planck Institute) |
| 7:30 pm - 7:50 pm | Melissa Moore (HHMI, Brandeis University)
"Exon junction complex structure and function" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Anne Ephrussi (EMBL Heidelberg)
"Mechanisms underlying oskar mRNA localization and translational control in the Drosophila oocyte" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Gideon Dreyfuss (HHMI, University of Pennsylvania School of Medicine)
"The SMN complex: architect of RNPs" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Jean Beggs (University of Edinburgh, UK)
"U snRNP biogenesis in yeast" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Reinhard Lührmann (Max Planck Institute)
"Assembly and structural dynamics of the mammalian spliceosome" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | EVOLUTION OF REGULATED RNA PROCESSING AND COMPLEX GENES |
| Discussion Leader: Tom Blumenthal (University of Colorado) |
| 9:00 am - 9:20 am | Francisco E. Baralle (I.C.G.E.B., Italy)
"Splicing regulatory elements and protein evolution" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Gil Ast (Tel-Aviv University)
"Constitutively spliced exons became alternatively spliced during evolution" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Manyuan Long (University of Chicago)
"Evolution of Alternative Splicing" |
| 10:10 am- 10:15 am | Discussion |
| 10:15 am - 10:35 am | Brenton Graveley (University of Connecticut Health Center)
"Deciphering Dscam alternative splicing by comparative genomics, high throughput arrays and RNAi screens" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Paula Grabowski (University of Pittsburgh)
"Roles of multi-component silencing codes in the regulation of alternative splicing in neurons" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Akila Mayeda (University of Miami)
"HMGA1 proteins as novel RNA-binding factors inducing disease-associated aberrant splicing" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Angela Krämer (University of Geneva)
"Analysis of in vivo RNA targets of human splicing factor SF1" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:25 pm | Tom Blumenthal (University of Colorado)
"New snRNAs and proteins involved in trans-splicing and operon pre-mRNA processing in C. elegans" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SMALL RNAS, SPLICING AND SILENCING |
| Discussion Leader: Alan Weiner (University of Washington) |
| 7:30 pm - 7:45 pm | Richard Carthew (Northwestern University)
"Gene Silencing by miRNAs and siRNAs in Drosophila" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Elisa Izaurralde (EMBL, Heidelberg)
"P-bodies: a place for miRNA mediated gene silencing" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Timothy W. Nilsen (Case Western Reserve University)
"miRNPs and translation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Masatoshi Hagiwara (Tokyo Medical and Dental School)
"Visualization of tissue-specific alternative splicing and cloning of the regulatory proteins in C.elegans" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Alan Weiner (University of Washington)
"How CCA-adding enzymes REALLY work" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - | Band: The IMMposters |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
