Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Redox Tools and Technologies
3:15 pm - 3:25 pm
"Novel Investigations of Peroxidasin (PXDN) Activity"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Optogenetic 1O2 Generation for Subcellular Induction of Lipid Peroxidation"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Computational Approach of the Catalytic Cycles of Flavoprotein Disulfide Reductases"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Cellular Signalling in a Redox Context: Mechanisms and Modulators
5:30 pm - 5:40 pm
"The Microbial Ergothioneine Transporter: Molecular Recognition, Regulation, and How Pneumococcus Uses this Dietary Antioxidant"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Hypoxia-Mediated Sulfide Accumulation Counteracts Electrophilic Toxicity in Rodent Hearts"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"A Redox Brake on STAT1: Reversible Cysteine Oxidation Limits Interferon Gamma Signaling"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Selective Hydrogen Peroxide-Induced S-Peroxiredoxinylation Tailors the Output from a MAPK Signalling Pathway"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Subcellular Localization of Glyoxalase 2 Regulates Compartmentalized Cell Metabolism"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Promoting Antioxidant Response through Bioreductively Activated Hydropersulfide Generators"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Glutaredoxins Rapidly Reduce Glutathione Hydroper- and Polysulfides"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Redox Regulation of CD45 in Immunity"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Redox Biology Across the Lifespan: Health, Disease, and Therapeutic Frontiers
9:00 am - 9:10 am
"A Role of NADPH Oxidases in Oxidative FGF2 Dimerization, a Key Event in Unconventional Secretion of the Tumor Cell Survival Factor FGF2"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Collagen as a Redox-Scavenging Protein"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Understanding NRF2 Activated lncRNA NMRAL2P Function in Non-Small Cell Lung Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Thioredoxin 1 Knockout Mice Exhibit Impaired Lung Development and Increased Levels of Apoptosis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Investigating the Redox Activity of Biomolecular Condensates"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Loss of NOX4 Disrupts Exercise-Induced Mitochondrial Quality Control in Skeletal Muscle"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Site-Specific Cysteine Oxidation Reshapes Redox Signaling in Ageing Skeletal Muscle"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Differential Reactivity of Bacillithiol, Mycothiol and Glutathione with Nitroxyl (HNO): Structural Determinants and Potential Biological Implications"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building Resilience in Academia
1:30 pm - 2:30 pm
Panel Discussion
Building Resilience in Academia
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes