Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Bridging Structure, Cell and Computational Biology
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"Dynamic Allostery: Make Sense of Disappearing Densities"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Deciphering Viral Fusion and Nuclear Transport In Situ "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Molecular Simulations Add Detail, Dynamics and Disorder to CryoET"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Instrumentation and Hardware
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"CryoSTEM Tomography in 2D, 3D, 4D, and More"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Enhancing Cryo-ET Contrast: Ongoing Work at CZ Imaging Institute"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Preventing Specimens from Interacting with the Air-Water Interface"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Advances in Integrated Light Microscopy and Focused Ion Beam Milling for Cryo-ET Sample Preparation"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Algorithms and Software
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Simulating the Cellular Context in Cryo-ET: Applications and Challenges"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"New Developments in NextPYP for In Situ Structure Determination"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Late-Breaking Topic
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Time-Resolved Studies and Structural Dynamics
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Prospects and Challenges of Nanofluidic Systems for Time-Resolved CryoEM Imaging"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Dissecting the Mechanisms of Eukaryotic Translation Initiation by Integrating Biochemical and Time-Resolved Cryo-EM Studies"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Investigating the Mechanisms of Bidirectional Transport by Dynein and Kinesin with Cryo-EM"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Unravelling the Enzymatic Machinery of COâ‚‚ Fixation and Energy Conservation in Anaerobic Life Using Integrative Structural Biology"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Expanding Single Particle Analysis Towards (More) Native Samples"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Molecular Structure and Function In Situ
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Unveiling Molecular Crowding In Situ "
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Integrated Structural Biology of the Native Malarial Translation Machinery and its Inhibition by an Antimalarial Drug"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"In Situ Structure and Arrangement of the Mitochondrial Oxidative Phosphorylation Machinery"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"High-Resolution In Situ Structures of Mammalian Respiratory Supercomplexes"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advancing 3DEM with Community Challenges and Contributions
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Annotating CryoET Volumes: A Machine Learning Challenge"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Late-Breaking Topic
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Multiscale, Correlative and Integrative Approaches
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Unlocking the Potential of Multimodal Imaging: Essential Considerations"
9:35 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Correlative Cryo Soft X-Ray Tomography Workflows: From CLXM to CLXEM"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Cartography of Human Organelles in Composition, Space and Time: A Lens to Understand Cellular States"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Building Structural and Spatial Interactomes by Cross-Linking Mass Spectrometry"
11:45 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Charting the Protein Universe for New Unknown Biology with the Help of AI"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure