| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Aging and tissue regeneration - The enemy within? |
| Discussion Leader: Sabine A. Eming (University of Cologne) |
| 7:40 pm - 7:45 pm | Welcome by Sabine A. Eming (University of Cologne) |
| 7:45 pm - 8:10 pm | Judith Campisi (University of California)
"Cellular senescence: Yin and Yang" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Andrew S. Brack (Harvard University)
"Skeletal muscle regeneration and aging" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Aleksandra Trifunovic (CECAD Cologne)
"Mitochondrial dysfunction and aging" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Optional social evening and poster viewing |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanotransduction and cellular responses |
| Discussion Leader: Thomas Krieg (University of Cologne) |
| 9:00 am - 9:05 am | Session Introduction by Thomas Krieg (University of Cologne) |
| 9:05 am - 9:30 am | Reinhard Fässler (Max Planck Institute of Biochemistry, Martinsried)
"Integrins must cooperate to sense the rigidity of a fibronectin micro-environment" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Sirio Dupont (University of Padua)
"Bridging mechanical cues into YAP/TAZ activity: which are the relevant F-actin regulators?" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:40 am - 11:05 am | Ellen A. Lumpkin (Columbia University)
"Mechanotransduction mechanisms in the mammalian epidermis" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Robert Nunan (Bristol University)
"Eph signaling regulates junctional dissolution during wound re-epithelialisation" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Sara Wickström (Max Planck Institute for Biology of Ageing, Cologne)
"Mechanisms of cellular force generation in matrix remodeling and fibrosis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Barrier homeostasis and regeneration |
| Discussion Leader: Livingston Van De Water (Albany Medical College) |
| 7:30 pm - 7:35 pm | Session Introduction by Livingston Van De Water (Albany Medical College) |
| 7:35 pm - 8:00 pm | Dennis R. Roop (University of Colorado)
"Identification of a novel mechanism for repairing epidermal barrier defects in utero" |
| 8:00 pm - 8:12 pm | Discussion |
| 8:12 pm - 8:37 pm | Angela Christiano (Columbia University)
"Stem cells and iPSCs in skin and hair follicle regeneration" |
| 8:37 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Michael J. Galko (University of Texas MD Anderson Cancer Center)
"Integration of cell migration and mechanosensing pathways in repair of the Drosophila larval epidermis" |
| 9:15 pm - 9:30 pm | Discussion |
| 9:30 pm | Optional social evening and poster viewing |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Whole organ and pattern regeneration |
| Discussion Leader: Enrique Amaya (University of Manchester) |
| 9:00 am - 9:05 am | Session Introduction by Enrique Amaya (University of Manchester) |
| 9:05 am - 9:30 am | Philip A. Beachy (Stanford University)
"Urothelial stem cells in regeneration and neoplasia" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Brigitte Galliot (University of Geneva)
"Hydra regeneration: a model of plasticity"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Group Photo / Coffee Break |
| 10:40 am - 11:05 am | Phillip A. Newmark (Howard Hughes Medical Institute, Urbana-Champaign)
"Regeneration in planarians: implications for understanding the developmental plasticity of parasitic flatworms" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Michael Brand (Center for Regenerative Therapies Dresden - CRTD)
"Bad things can be good: an inflammatory signal as a trigger of regeneration in the adult zebrafish brain" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Marjana Tomic-Canic (University of Miami)
"Inhibition of wound closure through a novel non-genomic glucocorticoid pathway: from plasma membrane to activation of beta-catenin and c-myc"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Parallels between wound healing and cancer |
| Discussion Leader: Alan Wells (University of Pittsburgh) |
| 7:30 pm - 7:35 pm | Session Introduction by Alan Wells (University of Pittsburgh) |
| 7:35 pm - 8:00 pm | Sabine Werner (ETH Zurich)
"Cytoprotective signaling pathways in tissue repair and cancer" |
| 8:00 pm - 8:12 pm | Discussion |
| 8:12 pm - 8:37 pm | Jeremy F. Reiter (University of California, San Francisco)
"Ciliary signaling in injury repair and tumorigenesis" |
| 8:37 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Paul Martin (University of Bristol)
"How inflammation impacts on cancer versus healing" |
| 9:15 pm - 9:30 pm | Discussion |
| 9:30 pm | Optional social evening and poster viewing |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Myeloid cells: unique sensors and effectors of tissue damage and repair |
| Discussion Leader: Luisa DiPietro (University of Illinois at Chicago) |
| 9:00 am - 9:05 am | Session Introduction by Luisa DiPietro (University of Illinois at Chicago) |
| 9:05 am - 9:30 am | Frederic Geissmann (King's College London)
"Nr4a1-dependent monocytes monitor endothelial cells and orchestrate their necrosis by neutrophils in response to a TLR7-mediated danger signal" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Nadia Rosenthal (Australian Regenerative Medicine Institute)
"Macrophages to the rescue in muscle regeneration" |
| 10:10 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:40 am - 11:05 am | Anna Huttenlocher (University of Wisconsin)
"Leukocyte attraction to tissue damage" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Judith E. Allen (University of Edinburgh)
"Macrophages and the Th2 immune response" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Ulrich auf dem Keller (ETH Zurich)
"Exploring the wound degradome"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Epigenetic control in tissue regeneration |
| Discussion Leader: Jeffrey M. Davidson (Vanderbilt University) |
| 7:30 pm - 7:35 pm | Session Introduction by Jeffrey M. Davidson (Vanderbilt University) |
| 7:35 pm - 8:00 pm | Renato Paro (ETH Zurich)
"Epigenetic memory in cancer and regeneration" |
| 8:00 pm - 8:12 pm | Discussion |
| 8:12 pm - 8:37 pm | Lorenz Studer (Memorial Sloan-Kettering Cancer Center)
"Directing neural differentiation for human disease modeling and cell therapy"
|
| 8:37 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:02 pm | Tanya Shaw (St. George's, University of London)
"The JNK stress-activated signalling pathway contributes to epigenetic reprogramming in wound-edge keratinocytes" |
| 9:02 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:22 pm | Wu-Min Deng (Florida State University)
"Tissue repair through cell competition and compensatory cellular hypertrophy in postmitotic epithelia"
|
| 9:22 pm - 9:30 pm | Discussion |
| 9:30 pm | Optional social evening and poster viewing |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 9:00 am - 12:30 pm | Signals in growth control and metabolism |
| Discussion Leader: Tanuja Harshani Peiris (University of California, Merced) |
| 9:00 am - 9:05 am | Session Introduction by Tanuja Harshani Peiris (University of California, Merced) |
| 9:05 am - 9:30 am | Enrique Amaya (University of Manchester)
"The role of reactive oxygen species during appendage regeneration" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Mercedes Costell (University of Valencia)
"Integrin-fibronectin interaction in vivo and in vitro"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:40 am - 11:05 am | Michael N. Hall (University of Basel)
"TOR signaling in growth and metabolism" |
| 11:05 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Alex P. Gould (MRC National Institute for Medical Research, London)
"Food for thought: nutrients and neural stem cells in Drosophila" |
| 11:45 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Ng Shyh-Chang (Harvard Medical School)
"Lin28 promotes mammalian tissue repair by reprogramming metabolism"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Tissue engineering and regenerative medicine |
| Discussion Leader: Paul Martin (University of Bristol) |
| 7:30 pm - 7:35 pm | Session Introduction by Paul Martin (University of Bristol) |
| 7:35 pm - 8:00 pm | Jeffrey A. Hubbell (EPFL Lausanne)
"Protein engineering of morphogen variants" |
| 8:00 pm - 8:12 pm | Discussion |
| 8:12 pm - 8:37 pm | Molly M. Stevens (Imperial College London)
"Materials-based strategies for tissue regeneration" |
| 8:37 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:30 pm | Duncan A. McGrouther (University of Manchester) and Paul Martin (University of Bristol)
"Open Discussion: The path to translation - cell biology on to the clinic" |
| 9:30 pm | Optional social evening and poster viewing |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |