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Tissue Repair and Regeneration

Gordon Research Conference

Recreating Tissue Complexity

June 1 - 6, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chair

Vice Chair

Colby-Sawyer College

541 Main Street

New London, New Hampshire, United States

Venue and Travel Information

Application Information

The application deadline for this meeting was May 4, 2025. You may still submit an application, which may be considered by the conference chair if there is still room available.

Conference Description

The Tissue Repair and Regeneration GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 Gordon Research Conference on Tissue Repair and Regeneration aims to bring together the international research community studying all aspects of this exciting topic. This will be a forum where current and future leaders share their unpublished cutting-edge findings and approaches, share ideas, challenge dogma, and network for future interactions that will strengthen the field. Attendees will be diverse in their methodology, ranging from model organisms to translational and clinical studies. Our scientific sessions will focus on:

· Regeneration of tissue complexity

· The impact of lifespan, ageing and senescence

· Parallels between tissue repair and regeneration with developmental processes

· Infection, inflammation and immunity

· Evolution of regeneration

· Tissue engineering and synthetic biology

· Extracellular matrix (from provisional wound matrix to fibrosis)

Related Meeting

This GRC will be held in conjunction with the "Tissue Repair and Regeneration" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Evolutionary, Developmental and Translational Insights into Regeneration Discussion Leader:
7:40 pm - 8:00 pm	Introduction by Discussion Leader
8:00 pm - 8:30 pm	"Complex Tissue Regeneration as an Emergent Phenomenon"
8:30 pm - 8:45 pm	Discussion
8:45 pm - 9:15 pm	"Developmental Origins of Tissue Regeneration"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Infection, Inflammation and Immunity Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Mitochondrial Dynamics in Wound Healing"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Sterile Inflammation Plays a Crucial Role in the Successful Regeneration of Adult Zebrafish Kidney"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:40 am	"AhR is a Key Regulator of the Macrophage Repair Program"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Dual Lineages of Langerhans Cells Cooperate for Immune Barrier Recovery After Skin Injury"
10:55 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Commensal Microbes Fortify Skin Barrier"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Characterizing the Architectural and Immune Dynamics of Liver Regeneration"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Live Imaging the Wound Inflammatory Response and the Consequences of Disrupted Circadian Clocks on Collagen Deposition and Angiogenesis Post-Wounding"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Characterization of Mechanoresponsive, Pro-Inflammatory Myeloid Cells During Fibrosis and Wound Healing"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Stem Cells and Cell Plasticity Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Peripheral Glia: A Regenerative Niche Driving Skin Wound Healing"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Staphylococcus aureus Intoxicates Stem Cells to Promote Wound Repair and Regeneration"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Somite-Independent Regeneration of the Axolotl Primary Body Axis"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"FASNated by Fat: WNT Signaling Activation Causes Early Decline of de novo Lipogenesis Leading to Lipid Depleted Dermal Adipocytes"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Mechanical Signaling Regulates Stem Cell Activity and Tissue Function"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Repair and Regeneration Across Cell and Organismal Lifespan Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Cold and Hot Fibrosis Define Clinically Distinct Cardiac Pathologies"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Altered Senescence Marker Dynamics in Aging-Associated Delayed Wound Healing"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Group Photo / Coffee Break
10:30 am - 10:50 am	"Exploring the Role of Cellular Ageing in Cutaneous Wound Repair"
10:50 am - 11:00 am	Discussion
11:00 am - 11:10 am	"Unlocking the Molecular Basis for Skin Regeneration in African Lungfish"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Niche-Specific Macrophage Loss Promotes Skin Capillary Aging"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Fetal-Like Reversion in the Regenerating Intestine is Regulated by Mesenchymal Asporin"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Kidney Development and Regeneration in the Axolotl (Ambystoma Mexicanum)"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Regeneration at Your Fingertips: Insights from Tissue Mechanics and the Extracellular Matrix"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Adaptation and Maladaptation to Tissue Damage Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Regeneration in the Uterus"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Iron-Induced Changes in Dermal Fat-Fibroblast-Signaling Axis Drive Disease Progression in Lipodermatosklerosis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Single-Cell Multi-Omics of Mouse Diabetic Wound Healing Reveals Stromal Cell Crosstalk Dysfunction"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Clonal Memory of Colitis Accumulates and Promotes Tumor Growth"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Epithelial-Stromal Crosstalk in Normal and Impaired Tissue Repair"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Biomechanical Influence on Tissue Regeneration Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Mechanosensing in Lung Fibrosis Models"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Elucidating Injury-Site Specific Regenerative Programs to Rebuild the Tendon"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Engineering On-Demand Curvature to Interrogate the Role of Nascent Matrix Dynamics in Epithelial Remodeling"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"FAK as a Central Mediator of Provisional Matrix Assembly During Stromal Repair"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Extracellular Matrix Remodeling at Tissue Interfaces in Response to Mechanical Loading"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Highly Regenerative Mammalian Fibroblasts Resist Biomechanical Cues to Drive Proliferation"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"DMP1 Activates VEGFA Expression Through ATF6 that Functions as an ER Stress Sensor"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Neural Repair: May the Force NOT be with You?"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Biological Design of Tissue Morphogenesis Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Synthetic Biology Approaches for Multicellular Mammalian Systems"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Targeted Epidermal–Dermal Crosstalk via Cell-Specific Engineered Exosomes"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Low Atherosclerosis Risk of Acellular Tissue Engineered Vessel (ATEV™)"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Replicating Age-Associated Immune Dysfunction Within Microfluidic Human Skin Equivalents"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Engineering Tissue Function: Build, Learn, Repeat"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Regenerating Tissue Complexity Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Deciphering Immune-Epithelial Crosstalk During Lung Repair"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Endothelial Cell Therapy to Repair the Liver Vascular Network and Alleviate Liver Diseases"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Cellular Communication That Regulates Acute Inflammation After Skin Injury"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Using Digit Tip Regeneration to Inform Regenerative Engineering of Complex Musculoskeletal Tissues"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Synthetic Regeneration for in situ Scale-Up of Engineered Liver Tissue Implants"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"ILP4 and InR Differentially Regulate Paclitaxel-Induced Nociceptive Hypersensitivity in Drosophila Larvae"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Inflammation, Damage and Repair in the Joint: Fibroblasts Decide!"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Provisional to Fibrotic Extracellular Matrix in Tissue Repair Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"It Will All Get Better With Time: The Role of Time in Driving Extracellular Matrix Formation and Tissue Repair"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Spp1+ Bone Marrow Derived Macrophages Link Inflammation to Post-Surgical Peritoneal Scarring"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Drosophila Chitinase-Like Proteins Act as Necrotic Opsonins to Enhance the Clearance of Damaged Cells During Wound Repair"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Wnt Signaling Activation in Mature Dermal Adipocytes Stimulates Lipolysis and Alters ECM Homeostasis"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Myofibroblast Matrix Memories of MSCs"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Tissue Repair and Regeneration (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$990.00

Conferee Shared Room:

$940.00

Conferee Off-Site:

$785.00

Guest Single Room:

$800.00

Guest Shared Room:

$750.00

Guest Off-Site:

$595.00

Child 4-12 yrs Shared Room:

$375.00

Child 4-12 yrs Off-Site:

$298.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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