| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Introduction to Toxicogenomics |
| Discussion Leader: Ben Van Houten, NIEHS |
| 7:30 - 8:00 pm | Samuel Wilson, NIEHS
Increasing Precision in Environmental Health Research |
| 8:00 - 8:10 pm | Discussion |
| 8:10 - 8:40 pm | Denis Hochstrasser, Geneva University Hospital
High Throughput Proteomic Analysis for Drug Discovery |
| 8:40 - 8:50 pm | Discussion |
| 8:50 - 9:20 pm | Raymond Tennant, NIEHS
Framework for Building Toxicogenomics Knowledge-base |
| 9:20 - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Functional Genomics |
| Discussion Leader: Michael Gallo, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School |
| 9:00 - 9:45 am | Jurgen Borlak, Fraunhoffer Institute
Transcription Factors |
| 9:45 - 10:00 am | Discussion |
| 10:00 - 10:30 am | Coffee Break and Group Photo |
| 10:30 - 11:15 am | Roger Ulrich, Rosetta Inpharmatics, Inc.
Expression Array Analysis of Hepatotoxicity |
| 11:15 - 11:30 am | Discussion |
| 11:30 - 12:15 pm | Jacques Retief, Affymetrix
Gene Ontologies and Other Approaches for Interpreting Microarray Data |
| 12:15 - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Microarray Technology and Disease Outcomes |
| Discussion Leader: Richard Paules, NIEHS |
| 7:30 - 8:00 pm | Tim Zacharewski, Michigan State University
Integrating Toxicogenomics into Predictive & Discovery Toxicology |
| 8:00 - 8:10 pm | Discussion |
| 8:10 - 8:40 pm | Sri Nagalla, Oregon Health and Science University
Genotoxins : Prospects of In Silico Mining the Pathways and Signatures |
| 8:40 - 8:50 pm | Discussion |
| 8:50 - 9:20 pm | Charles Perou, Lineberger Comprehensive Cancer Center, University of North Carolina
Cell Type Specific Responses to Chemotherapeutic Toxicants |
| 9:20 - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Proteins as the Effector Molecules |
| Discussion Leader: Leigh Anderson, Plasma Proteome |
| 9:00 - 9:45 am | B. Alex Merrick, NIEHS
Proteomic Analysis of Hepatotoxic Agents and Use of Subcellular Proteomics |
| 9:45 - 10:00 am | Discussion |
| 10:00 - 10:30 am | Coffee Break |
| 10:30 - 11:15 am | Paul Hermann, FDA
Protein Reactions May Hold the Key to Cancer |
| 11:15 - 11:30 am | Discussion |
| 11:30 - 12:15 pm | Daniel Liebler, University of Arizona
Proteomic Analysis of the Ubiquitin/Sumo Superfamily and Alkylation Stress Responses |
| 12:15 - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | How will the Toxicogenomics Direct us to Pathways of Disease? |
| Discussion Leader: Frank Sistare, FDA |
| 7:30 - 8:15 pm | Leigh Anderson
Plasma as a Source of Protein Toxicity Markers |
| 8:15 - 8:30 pm | Discussion |
| 8:30 - 9:15 pm | J. Carl Barrett, NCI
Genomics, Proteomics and Cancer |
| 9:15 - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Bioinformatics and Cross-Species Comparison |
| Discussion Leader: John Weinstein, NCI
|
| 9:00 - 9:45 am | John Quackenbush, TIGR
Beyond Expression: Extracting Meaning from Microarrays |
| 9:45 - 10:00 am | Discussion |
| 10:00 - 10:30 am | Coffee Break |
| 10:30 - 11:15 am | Judith A. Blake, Jackson Laboratory
Enabling Cross-Species Knowledge Sharing: The Emergence of Bio-Ontologies |
| 11:15 - 12:15 pm | John Weinstein, NCI
Integromic Analysis of Molecular Targets in Cancer Pharmacology and Toxicology |
| 12:15 - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 5:00 - 6:00 pm | Business Meeting |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Mechanisms of Action |
| 7:30 - 8:15 pm | George Orphanides, Syngenta
Expression Profiling in Mechanistic Toxicology |
| 8:15 - 8:30 pm | Discussion |
| 8:30 - 9:15 pm | Leona Samson, MIT
Complex Responses to Damaging Agents |
| 9:15 - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Modeling Disease Pathways with Toxicogenomics |
| Discussion Leader: Kenneth Ramos, Texas A&M University |
| 9:00 - 9:45 am | Cheryl Walker, University of Texas
Functional Genomics Approach to Defining Critical Determinants of Estrogen Action |
| 9:45 - 10:00 am | Discussion |
| 10:00 - 10:30 am | Coffee Break |
| 10:30 - 11:15 am | Cynthia Afshari, Amgen Inc.
Integration of Genomic and Biological Data Toward Pathway Mapping for Molecular Classification of Exposure Outcomes in Preclinical Models |
| 11:15 - 11:30 am | Discussion |
| 11:30 - 12:15 pm | Supriya Jayadev, Boehringer-Ingelheim Pharmaceuticals, Inc.
Biomarkers of Vascular Injury |
| 12:15 - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Are surrogate test animals valid for humans? |
| Discussion Leader: J. Carl Barrett, NCI |
| 7:30 - 8:15 pm | Dan Casciano, NCTR
A Systemic Approach to Assessing Toxicity in Animal Surrogates |
| 8:15 - 8:30 pm | Discussion |
| 8:30 - 9:15 pm | Frank Sistare, FDA
Integrating Toxicogenomics and Proteomics Data from Animals to Minimize Drug-Associated Cardiovascular Risks in Human Studies |
| 9:15 - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
