Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on TB Drug Development
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"Surviving XDR: Human Impact of Drug Resistance"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:55 pm
"The Search for Next Generation Antimalarials for Elimination"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Drugs for Activity Against the Pathogen
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Disarming Mycobacterium tuberculosis Antibiotic Tolerance and Resistance"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Siderophore Import by an Unusual Mycobacterial ABC Exporter"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Sugar Uptake and Metabolism in Mycobacterium tuberculosis : From Structure/Function to Potential Drug Targets"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Rationalizing Rational Drug Development: An Intrabacterial Perspective on Compound SAR"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Cephalosporins Cidal for both Replicating and Non-Replicating M. tuberculosis : Dual Pharmacophores and Modes of Action"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Attributes of an Ideal TB Drug
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Drug Delivery Strategies for Targeting Drugs to the Lungs"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"No Transporters Means No Transport: The Absolute Role of SLCs in the Uptake and Efficacy of Pharmaceutical Drugs"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
"Caseum: The Alpha and Omega of TB"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Treatment Shortening Potential of Targets in Cell Wall Biosynthesis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Lipid Metabolism as a Reservoir for the Identification of New Antimycobacterial Compounds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Inhibitors of the Mycobacterium tuberculosis Cell Wall Biosynthesis to Replace Isoniazid in the Mtb Drug Regime"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Betalactams for TB: The Bridge to the Clinic"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Inhibitors of Cell Wall Synthesis: Do They Have a Place in Novel TB Regimens?"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Direct Inhibitors of InhA Against Mycobacterium tuberculosis : Development of 4-Hydroxy-2-Pyridones as Anti-TB Agents"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening Potential of Targets in Transcription/Translation
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Predicting Rifampicin Tolerance in Clinical Isolates by Genetic Association"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Novel Approaches to Targeting M. tuberculosis RNA Polymerase"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"OTB-658, a Drug Candidate for DR-TB Treatment"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Novel Oxazolidinone-Class Protein Synthesis Inhibitors with Improved Safety Profiles"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Treatment Shortening Potential of Non-Traditional Drug Targets
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Allosteric De-Regulation of Metabolic Pathways as a Novel Antibiotic Strategy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"M. tuberculosis Proteostasis Network: Role in Drug Resistance"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The 'Trp' from Lead to Pre-Clinical Candidate"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Inhibition of the Biosynthetic Pathways for Essential Amino Acids"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Targeting Mycobacterial DNA Replication"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Enrichment of the Pipeline by Natural Products
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Discovery and Evaluation of Antitubercular Natural Products from Soil Bacteria"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Natural Product and Synthetic Biology Routes to New Antimycobacterial Agents"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Development of Spectinamide 1810, a TB-Active Analog of the Natural Product Spectinomycin"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Host-Dependent and Host-Directed Therapies
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Host-Dependent Targets: Using Complex Host Biology in Our Favor"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Genetic Determinants of Therapeutic Efficacy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Anti-Inflammatory and Anti-Microbial Host-Directed TB Therapies"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Siderophore-Dependent Inhibitors of Mycobacterium tuberculosis "
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Diazabicyclooctanes (DBOs) for Inhibition of Peptidoglycan Synthesis in Mycobacterium tuberculosis "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening and Clinical Trials Innovation
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"NexGen EBA: Assessing Sterilizing Potential of New Drugs and Regimens"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"Novel Strategies and Outcome Measures in TB Clinical Trials"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure