Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Therapeutic Strategies
7:40 pm - 8:05 pm
"Novel Vaccines and Immunotherapies to Eliminate the World's Most Common Congenital Infection: CMV"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Molecular Basis of African Swine Fever Virus Virulence in View of Vaccine Development"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Novel Antiviral for Dengue Virus Targets Flaviviral Polyprotein Translocation into the ER"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"All Birds with One Stone: The Proteostasis Network as a Target for Broad-acting Antivirals"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Basis for Potent Neutralization of Enterovirus D68 by Human Monoclonal Antibodies as a New Tool to Prevent Paralysis in Children"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune System Activation and Viral Immune Evasion
9:00 am - 9:20 am
"Multiple Strategies of Evading the Innate Antiviral Response by the Dengue Virus NS5 Protein"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Virus-Host interaction Studies and the Search for a Cure Against Hepatitis B Virus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Targeting Vulnerability of EBV Infection for Vaccine Development"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Varicella Zoster Virus Modulates IFN? Signaling to Favor Virus Spread"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Tiny Messengers: Peptides in Anti-Viral Innate Immunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Bispecific Antibodies Targeting Two Glycoproteins on SFTSV Synergistic Neutralization and Protection in a Mouse Model"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Short 5' UTRs are a Novel Molecular Pattern for Viral Inhibition by IFIT2 and IFIT3"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Cellular Antibody Affinity-Based CRISPR Screening Identifies JUNB as an Anti-Viral Factor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Antibodies Targeting Crimean-Congo Hemorrhagic Fever Virus GP38 Limit Vascular Leak and Viral Spread"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral and Host Gene Regulation
6:00 pm - 6:20 pm
"Defining the Landscape of Host Defenses Against Emergent Viruses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mechanisms for Differential Interferon Signaling Across Lung Tissue During an Influenza Virus Infection"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"HSV-1 and Chromatin Loops: Making the Right Connections to Initiate Reactivation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Viral Hijacking of Pioneer Factor Activity Reveals a Novel Function for a Developmental Transcription Factor SOX18"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Efficient and Accurate Detection of Viral Sequences at Single-Cell Resolution Reveals Putative Novel Viruses Perturbing Host Gene Expression"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Decoding Anti-viral Immune Responses from the Cell to the Lactating Mammary"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Mechanisms of Mast Cell Detection of Dengue Virus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Spatio-Temporal Analysis of Vaccinia Virus Infection and Host Response Dynamics Using Single-Cell Transcriptomics and Proteomics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Regulation of Human Cytomegalovirus by a Host mRNA Deadenylase Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Early Phase of HIV Replication"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel Antiviral Restriction Factors of HSV-1"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Glucose-Independent Human Cytomegalovirus Replication is Supported by Metabolites that Feed Upper Glycolytic Branches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Basis of Zika Virus NS5 Interaction with the Rootlet Fiber and its Link with Associated Ciliopathy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Encephalitic Alphavirus Infection of Human iPSC-Derived Neurospheres Alters Rho GTPase Pathways and Impairs Neurite Outgrowth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Impact of Paternal Viral Infection on Offspring Antiviral Immunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"From Viremia to Persistence: Exploring how Ebola Virus Colonizes the Central Nervous System"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"An Integrated Framework for Evaluating Viral Zoonotic Threats"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Immune Cell Recruitment Promotes Paralysis in a Mouse Model of Enterovirus D68 Disease"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Impact of Pre-Existing Immunity on Zoonotic Influenza Virus Transmission and Pathogenesis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Structural Studies of Bunyavirus Glycoprotein Complexes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"TRIM21 Effects Intracellular Neutralization of Incoming Viruses Via Selective Autophagy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Virion Entry Pathway Determines HCMV Infection Outcome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"TMEM30a Facilitates Murine Norovirus Entry and Persistent Enteric Infection by Limiting Exoplasmic Phosphatidylethanolamine"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Entry of Human Herpesvirus 6"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Virus Adaptation to Heparan Sulfate Comes with Capsid Stability Tradeoff"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"SARS-CoV-2 ORF3a Drives Dynamic Dense Body Formation for Optimal Viral Infectivity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Independent Role of WDR81 in Virus Entry and Programmed Cell Death"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Insights into HIV-1 Env-Mediated Membrane Fusion Using Organoid Models and Microscopy Techniques"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Regulation of the NLRP1 Inflammasome by HSV-1"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Contributions of Merkel Cell Polyomavirus to Merkel Cell Carcinoma"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"RNA Decay and Viral Infection: Deciphering the Viral-Host Arms Race to Control RNA Stability"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"A Viral lncRNA Associates with the HSV-1 Genome and a Nuclear Membrane Protein to Regulate the Repression of Lytic Genes"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Delta Viruses Spread Through a Viral Trojan Horse"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Cytoplasmic mRNA Decay by Viral and Antiviral Nucleases Inhibits Cellular Transcription"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"G-quadruplex Regulation of Varicella-Zoster Virus Glycoprotein C Expression and Virion Release"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A Zebrafish-based In Vivo Model of Zika Virus Infection Unveils Alterations of the Glutamatergic Neuronal Development and NS4A as a Key Viral Determinant of Neuropathogenesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Membrane Tethering by the Host GTPase Atlastin-2 is Critical for Flavivirus Replication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dual Receptor Specificity for Sialic Acid and MHC Class II in Human and Avian Influenza A Virus"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Determining RNA-Binding Activity of IFIT3 and its Effect on Pro-viral Activity in Influenza A Virus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Noncanonical CircRNA Biogenesis Driven by Alpha and Gamma Herpesviruses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Gammaherpesvirus Infection Elicits Transfer RNA Cleavage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Surfaceome Profiling of the Human Cytomegalovirus RL11 Family Reveals Modulators of the Immune and Cardiovascular Systems"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Viral Evolution and Adaptation
6:00 pm - 6:20 pm
"Genomic Surveillance and Characterization of Microbial Threats Facilitates Early Detection and Containment of Disease of Outbreaks in West Africa"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"What Ribosome Profiling Can Teach us About Zika Virus?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"SARS-CoV-2 Intrahost Persistence: Implications for Seasonality and Vaccination"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"A Human Cerebral Organoid Model to Investigate the Host-Pathogen Determinants of Ebola Virus Persistence in the Central Nervous System"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Structural Systems Virology Reveals the Proteome-Wide Atlas of Human Herpesvirus Protein Families and their Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure