Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Frontiers in Visual System Development and Disease |
| Discussion Leaders: Nadean Brown (University of California, Davis, USA) and Graeme Mardon (Baylor College of Medicine, USA) |
7:40 pm - 8:20 pm | Patricia D'Amore (Schepens Eye Research Institute, Massachusetts Eye and Ear, USA) "Retinal Vascular Development and Pathology" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Carla Shatz (Stanford University, USA) "Saving the Synapse: Pruning, Plasticity and Amblyopia" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Model Organism Genetics in Visual System Development |
| Discussion Leader: Ruth Ashery-Padan (Tel Aviv University, Israel) |
9:00 am - 9:20 am | Hugo Bellen (Baylor College of Medicine, USA) "Pathogenic Mechanisms of Photoreceptor Neurodegeneration Associated with Mitochondrial Proteins" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Deborah Stenkamp (University of Idaho, USA) "Retinoids and Thyroid Hormone Regulate Differential Expression of Tandemly-Replicated Cone Opsin Genes in the Zebrafish" |
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Michael Perry (New York University, USA) "Butterfly Eye Evo-Devo: Stochastic Patterning and Expanded Color Vision" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Brian Link (Medical College of Wisconsin, USA) "Apical Cell Junction Remodeling Modulates Signaling During Retinal Development" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jessica Treisman (Skirball Institute of Biomolecular Medicine, NYU Langone Medical Center, USA) "Cell Fate Specification by the Glass Transcription Factor" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Joseph Brzezinski (University of Colorado School of Medicine, USA) "Regulation of Bipolar Cell Genesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ryan MacDonald (University of Sheffield, United Kingdom) "Identifying the Molecular Mechanisms of Müller Glial Patterning and Morphogenesis in the Zebrafish Retina" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Seema Agarwala (University of Texas at Austin, USA) "BMP Signaling Differentially Regulates Choroid Fissure Closure Along the Proximo-Distal Axis of the Amniote Eye" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regenerating Vision |
| Discussion Leader: Valerie Wallace (Toronto Western Research Institute, Canada) |
7:30 pm - 7:50 pm | Sabine Fuhrmann (Vanderbilt University School of Medicine, USA) "Ventral Optic Cup Morphogenesis: Closing the Gap" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Katia Del Rio-Tsonis (Miami University, USA) "NAC: A Unique Inducer of Chick Retina Regeneration" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | W. Ted Allison (University of Alberta, Canada) "Specifying Rods and Cones - Insights from an Evo-Devo Approach" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Daniel Goldman (University of Michigan, USA) "Fgf Signaling and Retina Regeneration in Zebrafish" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Stem Cells to Organs |
| Discussion Leader: Monica Vetter (University of Utah, USA) |
9:00 am - 9:20 am | Valeria Canto-Soler (Wilmer Eye Institute, Johns Hopkins University, USA) "Retinal Organoids: Challenges and Opportunities for Pre-Clinical Applications" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Rachael Pearson (University College London, United Kingdom) "Donor and Host Photoreceptors Engage in Material Transfer Following Transplantation of Post-Mitotic Photoreceptor Precursors" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jennifer Aparicio (Children's Hospital Los Angeles, USA) "Temporal Expression of CD184(CXCR4) and CD171(L1CAM) Identifies Distinct Early Developmental Stages of Human RGCs in Embryonic Stem Cell Derived Retina" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Nady Golestaneh (Georgetown University, USA) "Stem Cell-Based Disease Model of Age-Related Macular Degeneration" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Timothy Plageman (Ohio State University, USA) "Lens Placode Cell Anisotropic Geometry Is Mediated by Planar Polarized Inhibition of Junctional Contraction During Invagination" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Wei Liu (Albert Einstein College of Medicine, USA) "Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Guillermo Oliver (Northwestern University, USA) "Identification of New Players in the Process of Neuroretina Fate Differentiation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Anna La Torre (University of California, Davis, USA) "Reelin Signaling Termination in Retinal Lamination" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Circuitry, Synapses and Biologic Clocks |
| Discussion Leader: Claude Desplan (New York University, USA) |
7:30 pm - 7:50 pm | Sujata Rao (Cleveland Clinic, USA) "Regulation of Ocular Vasculature by a Neuronal Clock" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Jin Woo Kim (Korea Advanced Institute of Science and Technology, South Korea) "LIM Code of Visual Adaption in the Mouse Retina" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Peter Stoilov (West Virginia University, USA) "A Photoreceptor-Specific Splicing Program Controlled by Mushashi1" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Iris Selecker (The Francis Crick Institute, United Kingdom) "Astrocyte-Like Glia During Visual Circuit Assembly in Drosophila" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Steven Altschuler (University of California, San Francisco, USA) "Wiring Principles of Neural Superposition in the Fly Visual System" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ocular Disease Mechanisms |
| Discussion Leader: Shiming Chen (Washington University in St. Louis, USA) |
9:00 am - 9:20 am | Rui Chen (Baylor College of Medicine, USA) "Connecting Cilium and Photoreceptor Cell Degeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Brian Perkins (Cleveland Clinic, USA) "Genetic Interactions Between the Cilia-Related Genes cep290 and arl13b Regulate the Severity of Photoreceptor Degeneration" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Joseph Corbo (Washington University School of Medicine in St. Louis, USA) "The Mechanistic Basis of Seeing (Infra)Red" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Salil Lachke (University of Delaware, USA) "Mediating CELF-Control in Eye Development" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Claudia Benavente (University of California, Irvine, USA) "Role of Epigenetics in Retinal Degeneration and Retinoblastoma" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ryan Thummel (Wayne State University School of Medicine, USA) "A Zebrafish Model for the Vision Defects Associated with a Novel Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Brian Brooks (National Eye Institute, NIH, USA) "Nlz2 (Zfp503) Is Required for RPE Differentiation and Optic Fissure Closure" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Non-Neural Cells and Tissues |
| Discussion Leader: Ales Cvekl (Albert Einstein College of Medicine, USA) |
7:30 pm - 7:50 pm | Melinda Duncan (University of Delaware, USA) "Lens Development: Control of Cell Fate Decisions via Cross Talk Between Signal Transduction Pathways" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Markus Friedrich (Wayne State University, USA) "Adult Lens Deposition in a Cave Beetle" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Francesca Pignoni (State University of New York Upstate Medical University, USA) "The Non-Neural Tissue of the Drosophila Eye Disc: Mitf/MITF, Arm/ß-Catenin and Yki/YAP/TAZ Promote Peripodial Identity and Suppress Retina Identity" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Xin Zhang (Columbia University, USA) "Proteoglycan Regulation of Astrocyte Migration and Angiogenesis" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Conserved Mechanisms of Gene Regulation |
| Discussion Leader: William Jeffery (University of Maryland, USA) |
9:00 am - 9:20 am | Monica Vetter (University of Utah, USA) "Extrinsic and Intrinsic Modulation of Progenitor Proliferation and Differentiation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marek Mlodzik (Icahn School of Medicine at Mount Sinai, USA) "Wnt-Frizzled Planar Cell Polarity Signaling in Photoreceptor Patterning in the Retina" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Andrea Viczian (State University of New York Upstate Medical University, USA) "Distinct Cis-Acting Regions Control Six6 Expression During Early and Late Stages of Eye Formation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Makoto Sato (Kanazawa University, Japan) "Mathematical Modeling and Genetic Analysis of the Proneural Wave in the Fly Visual Center" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Nicholas Baker (Albert Einstein College of Medicine, USA) "The HLH Protein Network that Controls Neural Fate" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Robert Johnston (Johns Hopkins University, USA) "Natural Variation in Binding Site Affinity Controls Stochastic Gene Expression and Color Perception in Flies" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Seth Blackshaw (Johns Hopkins University School of Medicine, USA) "Molecular Mechanisms of Developmental Competence in Retinal Progenitors" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolutionary Changes to the Visual System |
| Discussion Leader: Zbynek Kozmik (Institute of Molecular Genetics, Czech Academy of Sciences, Czech Republic) |
7:30 pm - 7:50 pm | Megan Porter (University of Hawaii at Manoa, USA) "The Molecular Evolution and Development of Visual System Complexity in Stomatopod Crustaceans" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Elke Buschbeck (University of Cincinnati, USA) "Probing the Ubiquity of Developmental Patterns in a Complex Beetle Eye" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Adriana Briscoe (University of California, Irvine, USA) "Sexual Dimorphisms in Butterfly Vision: Genes, Physiology and Behavior" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | William Jeffery (University of Maryland, USA) "Evolution of Visual System Degeneration in Blind Cavefish" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |