Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structural Studies of Wnt Signaling
7:40 pm - 8:05 pm
"Molecular Mechanisms in Wnt/Beta-Catenin Signal Transduction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Structure and Mechanism in the Assembly and Modulation of Wnt Signalling Complexes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Structure of Wnt Enhanceosome"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Biochemical Reconstitution of Wild-Type and Oncogenic Core β-Catenin Destruction Complexes"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Wnt Regulation of Development and Stem Cell Biology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Control of Wnt/Beta-Catenin Signaling by the Ubiquitin System"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"The Ubiquitin Ligase HUWE1 Regulates Canonical WNT Signaling Independently of Changes in Beta-Catenin Abundance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Mutation-Guided Insights in Wnt Signalling Regulation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Supramolecular Assembly of the Beta-Catenin Destruction Complex and the Effect of Wnt Signaling on Its Localization, Molecular Size and Activity In Vivo "
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Consequences of Dishevelled Phosphorylation by CK1 Epsilon"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single Molecule Dynamics of Dishevelled at the Plasma Membrane and Wnt Pathway Activation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Control of Gene Expression
7:30 pm - 7:55 pm
"Oscillatory Wnt-Signaling Dynamics During Mouse Embryo Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Sox9 and Wnt Signaling: Two Sides to the Coin"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Novel Target Molecule of Wnt/Beta-Catenin Signaling and Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Cellular Reprogramming Regulated by Wnt-Cholesterol Pathway"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Secretion and Receptor Interactions
9:00 am - 9:25 am
"Selective Pharmacological Modulation of Wnt-Receptor Complexes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Role of Evi/Wls in Intracellular Wnt Trafficking and Wnt Secretion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Wnt and TGF-β Coordinate Growth and Patterning to Give Rise to Size-Dependent Behaviors"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Mechanism of Long Range Wnt Transport"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"EGFR Is Required for Wnt9a-Fzd9b Signal Activation During Hematopoietic Stem Cell Development"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Rational Activation of Wnt Signalling Circuits to Promote Directed Differentiation of Human Embryonic Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Naked Promotes Wnt/β-Catenin Signalling by Targeting Deactivated Wnt Signalosomes for Autophagy-Dependent Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Fzd-Lrp Bispecific Wnt Stimulating Surrogate Induces Bone Growth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alternative Wnt Signaling Pathways
7:30 pm - 7:55 pm
"Role of Wnt-PCP Signaling in Positioning of the Basal Body for Left-Right Symmetry Breaking"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Mechanisms of Wnt5a-Ror Signaling in Development and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Wilms Tumour Gene TRIM28 Eencodes a Negative Regulator of Wnt Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Conserved Molecular Switch in Class F Receptors Regulates Receptor Activation and Pathway Selection"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in Development
9:00 am - 9:25 am
"Control of Adult Muscle Regeneration by Wnt Signaling Pathways"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Dissecting the Function of Fzd Subtypes During Bone Development"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"A Negative Regulatory Mechanism of Wnt/PCP Signaling by Targeting Vangl Proteins for Ubiquitination and Degradation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Molecular Dissection of Planar Polarity Signalling Mechanisms in Drosophila "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Identification of Wnt5a Downstream Targets During Early Development in Mouse"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"TBX3 Acts as an Activation-Switch of the Beta-Catenin/BCL9 Transcriptional Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Tissue-Specific Regulation of Direct Wnt Target Genes in Early Embryonic Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Interaction of Casein Kinase 1 Delta/Epsilon and Dishevelled Within Puncta in a Novel Cortical Domain at the Vegetal Pole Specifies Egg and Embryo Polarity in Sea Urchins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Liver Homeostasis and Wnt Signaling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Lgr5 Stem Cells in Wnt-Driven Regeneration and Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Procr and Wnt Signaling in Regulating Adult Stem Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Progenitors Oppositely Polarize WNT Activators and Inhibitors to Orchestrate Tissue Development"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in Disease and Cancer
9:00 am - 9:25 am
"Wnt Signaling in Stem Cells and Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Frizzled7 Functions as a Wnt Receptor in Gastrointestinal Epithelial Stem Cells: Implications for Cancer Growth and Progression"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Wnt-Dependent LncRNAs in RNF43-Mutant Pancreatic Cancer"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"The Cross-Talk Between Tumor Cell-Intrinsic Beta-Catenin Activation and Anti-Tumor Immunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Secreted WNT Inhibitor Notum Is Required by Apc-Mutant Cells for a Competitive Edge over Wildtype Intestinal Stem Cells to Rule the Intestinal Crypt"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Identification of Common Wnt Target Genes in Adult Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"APC Inactivation in Early Intestinal Tumorigenesis Leads to Compromised Cellular Organisation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Choline Addiction Enables Imaging of Beta-Catenin-Mutated Hepatocellular Carcinoma and Provides a Therapeutic Target"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling in Regeneration
7:30 pm - 7:55 pm
"The Cnidarian Wnt Code: Deciphering Early Wnt Ligand-Receptor Interactions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Tissue Specific Regulation of Wnt-Signaling Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Apoptotic Cells Release Wnt Ligands Driving Stem Cell Proliferation and Skin Regeneration"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Wnts and Red Blood Cells"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
