Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Molecular Mechanisms/Structural Biology
7:40 pm - 8:05 pm
"Wnt Signalosome Assembly Is Governed by Conformational Flexibility of Axin and AP2 Clathrin Adaptor"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Molecular Mechanisms of the β-Catenin Destruction Complex"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Molecular Insights into Wnt Ligand-Specific Signaling"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Unusual G Protein Coupling by FZD G Protein-Coupled Receptors"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stem Cell Regulation and Tissue Homeostasis
9:00 am - 9:25 am
"How Stem Cell Self Renewal Intersects with the Cell Cycle"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"How to Grow a Cytoneme for Contact Mediated Intercellular Communication"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Spatial Mapping of Telocytes along the Crypt-Villus Axis Reveals Functional Zonation in the Intestinal Epithelium"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Localized Wnt-Signaling Promotes Asymmetric NuMA-Dependent Oriented Divisions and Unequal Apportioning of Mitochondria"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"A Revised Model of Tissue Regeneration in the Gut Epithelium"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Cell Identity Decisions in the Intestinal Epithelium: A WNT-WNT Situation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Tbx3 is Required for Mammary Gland Expansion During Puberty"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling in Development
7:30 pm - 7:55 pm
"WNT Signaling Dynamics Controlled by KDM5C during Development Influence Cognition"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"From Progenitor to Progeny: How Wnt Signaling Shapes Cell Fate Through Cell Cycle Control"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"GSK3 and Cellular Dormancy: Linking Embryonic Diapause to Cancer Survival"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Wnt/β-Catenin Coordinates Muscle Spindle Development by Regulating Capsule Differentiation, Intrafusal Fiber Nuclei Aggregation, and Proprioceptive Nerve Endings"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Physiological Cell Competition Ensures Robust Tissue Patterning"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in Cancer and Disease
9:00 am - 9:25 am
"Age- and Dosage-Dependent Effects of Wnt Signaling in Adrenal Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Interplay of the Clock and Wnt Signaling"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
"A Novel RASopathy Caused by Hyperactive Non-Canonical Wnt Signalling"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Identifying an Efficacious Therapeutic for CTNNB1 Syndrome Using Preclinical Mouse and Patient Cell Models"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Targeting Wnt "Just-Right" Levels in Colorectal Cancer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Fate Decisions During Hydra Regeneration: Deciphering the Interplay of Generic Wound Signals and Tissue Competence"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Unraveling p140Cap as a modulator of Wnt/β-Catenin signaling pathway in Breast cancer"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Cell Fate Decisions are Controlled by Lysosomal Rewiring of Nutrient Utilization"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Beta-Catenin-Independent Signaling
7:30 pm - 7:55 pm
"Wnt PCP Signaling in Development and Regeneration"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Mechano-Gradients Drive Morphogen-Noise Correction to Ensure Robust Patterning"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Deciphering the Role of Lipidation in Non-Canonical Versus Canonical Wnt Secretion and Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Structural Basis of Human VANGL-PRICKLE Interaction"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"DVL1 Regulates Global Transcriptomic Changes and Associates With the Transcription Factor ETS1"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"WNT2B Signals via the Non-Canonical Wnt/PCP Pathway in Mouse and Human Adrenals"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Therapeutic Intervention/Manipulation
9:00 am - 9:25 am
"Manipulating Cell Fate with Frizzled Agonists"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Novel Synthetic Wnt Signal Agonists and their Therapeutic Applications"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Targeting the Wnt Signaling Modulator DKK1 for Oncology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Combinatorial Wnt-Agonist Antibody Library-Derived Therapeutics"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Discovery, Validation and Clinical Application of FOG-001, a HeliconTM Peptide Inhibitor of the beta-catenin:TCF interaction”."
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Towards Targeting the Undruggable: Targeted Protein Degradation of the Oncogene Beta-Catenin"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Elucidation of the Mechanism of Action of a Small Molecule WNT Sensitizer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"New Insights into the Wnt-Signaling Induced Nuclear Translocation of β-Catenin"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"The Impact of Wnt signaling on the Genome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Condensates Across Functions: β-Catenin in Transcription and Cellular Adhesion"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Bypassing Beta-Catenin: Direct Targeting of TCF/LEF Transcription Factors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Distinct IDR-Mediated Condensates of TCF3 and LEF1 Differentially Regulate Wnt-Specific Transcriptional Activity"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Regulation of CK1-Mediated Dishevelled Phosphorylation by DDX3X RNA Helicase"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of WNT9A/FZD9 Signaling Specificity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A novel family of Wnt-Cleaving Astacin Proteases (WCAPs) in Metazoans"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Tissue-Specific Expression of WNT4 via 3D Looping of Conserved and Species Specific Enhancers"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Proximity Labeling and CRISPRi Screening Reveals Novel Regulators of Wnt Signaling"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"A Targeted CRISPR Screen for Regulators of Wnt Signalosome Assembly by Dishevelled"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Glycosaminoglycan-Mediated Transport and Action of Wnts"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"WNT-Induced Multisite Phosphorylation of the Intrinsically Disordered Region of DVL Controls DVL Conformation, Interaction with FZD, and Is Essential for Wnt/β-Catenin Signal Transduction"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanism of WNT5A Variants Causative of Autosomal Dominant Robinow Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Identification and Hierarchical Assignment of WNT/CTNNB1 Signaling Regulators Using Genetic Screens with Dual-Reporters in Haploid Human Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Image-Based Screens Identify Regulators of Endogenous Dvl2 Biomolecular Condensates"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Base Editing Uncovers Regulatory Principles Governing WNT Destruction Complex Activity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Unlocking Pancreatic Islet Regeneration by Modulating Rspo1-Wnt Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Ubiquitin Ligase HUWE1 Controls the Balance Between β-Catenin WNT Signaling Activity and Cell Adhesion Functions by Antagonizing the Destruction Complex"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Convergent Mechanisms in Wnt and Hedgehog Signaling"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure