SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | Keynote Lecture |
| Polly Matzinger, Ph.D. (National Institutes of Health, Bethesda, MD)
"The Danger Hypothesis and Adverse Drug Reactions" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanistic Aspects of Idiosyncratic Drug Reactions |
| Discussion Leader: Kevin Park, Ph.D. (University of Liverpool, UK) |
| Werner Pichler, M.D. (Institute of Immunology and Allergology, Bern Switzerland)
"Immune Recognition of Drugs by T cells" |
| Lance Pohl, Ph.D. (NIH)
"Immune Response to Drugs in the Liver" |
| Craig Svensson, Ph.D. (University of Iowa)
"Immune response to Drugs in the Skin" |
12:30 pm | Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Basic Immunology with Relevance to Adverse Drug Reactions |
| Discussion Leader: Cynthia Ju, Ph.D. (University of Colorado) |
| Juan LaFaille, Ph.D. (New York University Medical Center)
"Regulatory T cells and the Immune Response" |
| Andrew Fontenot, M.D. (University of Colorado Health Sciences Center)
"MHC and the Immune Response" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Predictive Screens |
| Discussion Leader: Tim Ryan, Ph.D. (Lilly Research Laboratories) |
| Bruce Car, Ph.D. (Bristol-Myers Squib)
"Systems biology (transcriptomic, metabonomic, proteomic) enhanced screening strategies: advantages and pitfalls" |
| Greg Slatter, Ph.D. (Merck)
"Concordance in drug clearance networks among humans and lab animal species" |
| Randy Peterson, Ph.D. (Harvard Medical School)
"The zebrafish - disruptive technology for drug screening" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Role of Regulatory Agencies in Encouraging and Enabling Research in Idiosyncratic Drug Reactions |
| Discussion Leader: Kenneth Hastings, Ph.D. (CDER. US FDA) |
| John Senior, Ph.D. (CDER, US FDA)
"Searching for Needles in Haystacks: The Problems of Recognizing Drug-Induced, Idiosyncratic, Serious but Uncommon Liver Injuries in People Exposed to Drugs" |
| Kenneth L. Hastings, Ph.D. (CDER, US FDA)
"Immune-based Idiosyncratic Drug Reactions: A Regulatory Conundrum" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hepatotoxicity |
| Discussion Leader: Paul Watkins, M.D. (University of North Carolina) |
| Paul Watkins, M.D. (University of North Carolina, Chapel Hill)
"The Drug Induced Liver Injury Network (DILIN) - Progress and future directions |
| Munir Pirmohamed, M.D., Ph.D. (University of Liverpool)
"Drug-induced liver injury: working towards better diagnostic and preventive strategies" |
| Dan Burns, Ph.D. (GlaxoSmithKline, RTP, NC)
"Genomics and Hepatotoxicity: Lessons learned at GSK" |
| James Boyer, M.D. (Yale University, New Haven, CT)
"Mechanisms of cholestatic hepatotoxicity" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Selected Abstracts for Oral Presentation |
| Discussion Leader: Tom Kawabata, Ph.D. (Pfizer, Groton, CT) |
| Six 15 minute presentations to be selected from posters |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pharmacogenetics |
| Discussion Leader: Michel Eichelbaum, M.D. (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany) |
| Munir Pirmohamed, M.D., Ph.D. (University of Liverpool)
"Genetic Aspects of Drug-Induced Hypersensitivity Reactions" |
| Matthias Schwab, M.D. (Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany)
"Pharmacogenetics of Thiopurine Drug-Related Toxicity" |
| Leif Bertilsson, Ph.D. (Karolinska Institute Stockholm)
"Contribution of polymorphisms of drug transporters, metabolizing enzymes and receptors for antidepressant and neuroleptic drug associated adverse drug reactions" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Drug-Induced Long QT Syndrome |
| Discussion Leader: Peter Siegl, Ph.D. (Merck) |
| Peter Siegl, Ph.D. (Merck)
"Introduction: Drug-Induced Long QT Syndrome, Torsade de Pointes Arrhythmia and ICH Guidelines" |
| John Mitcheson, Ph.D. (Department of Cell Physiology and Pharmacology, University of Leicester)
"Molecular mechanisms for drug interactions with hERG that cause long QT syndrome" |
| Daniel Bloomfield, M.D. (Merck)
"From Bedside Back to Bench: Understanding the Clinical Assessment of QTc Interval Prolongation in the Context of In Vitro and In Vivo Models for Assessing Cardiac Repolarization" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |