Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Exploring Neural Mediators of Cue-Triggered Reward Seeking
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Exploring Neural Mediators of Cue-Triggered Reward Seeking"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Neural Circuitry of Excessive Alcohol Drinking and Other Maladaptive Behaviors
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Neurobiological Contributions to the Diagnosis, Prevention and Treatment of Alcohol Use Disorders: NIAAA Update"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Role of mPFC Neuronal Ensembles in Reward Seeking and Alcohol Addiction"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Ethanol Withdrawal Produces Opposing Synaptic Alterations of Prelimbic and Infralimbic Terminals in the Rat Basolateral Amygdala"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Dynorphin/Kappa Opioid Receptor Changes with Immediate and Long-Term Stress/Ethanol Exposure"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Alcohol Engages Dynorphin/Kappa Opioid Receptor Signaling in the Extended Amygdala to Alter Behavior"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"CRISPR-Cas9 Editing of Hypocretin (Orexin) Receptor Genes in Cell Type-Specific Extended Amygdala Neurons Modulating Alcohol Drinking and Withdrawal-Related Behavior"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Mechanisms in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Gins of Our Fathers: Intergenerational Epigenetic Effects of Alcohol"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Neuroepigenetics: The Next Evolution in the Molecular Basis of Alcoholism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Multi-Tissue DNA Methylation Analysis Implicates Both Pre-Existing Risk and Induced Effects of Chronic Alcohol Use"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol Effects on CNS Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Migration Defects and Enduring Behavioral Impairments in a Mouse Model of Prenatal Ethanol Exposure"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"From Germ Cells to Adolescence Brain, Alcohol Programs to Alter the Development of the Neuroendocrine Immune Brain"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Altered Spatial Coding by Hippocampal Place Cells Following Moderate Prenatal Alcohol Exposure"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Effect of Developmental Alcohol Exposure on Neuronal Plasticity and Multisensory Integration in the Cortex"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Ribosome Dysbiogenesis Is a Novel Apoptotic Effector in Alcohol-Exposed Neural Crest"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"The Influence of Age and Moderate Prenatal Ethanol Exposure on CRF1 Receptor Regulation of GABAergic Transmission Within the Central Amygdala in Sprague Dawley Males"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Molecular Gatekeepers of Alcohol Signaling
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"A Molecular Mechanism for Choosing Alcohol over a Natural Reward"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Role of BK Channels in the Behavioral Effects of Alcohol"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"New Molecular Regulators of Alcohol-Drinking Behaviors"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Limiting the Afterhyperpolarization Drives Heavy Alcohol Drinking"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vulnerability and Resilience to Alcoholism and Comorbid Affective Disorders
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Traumatic Stress Reactivity and Neural Mediators of Alcohol Drinking"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Endocrine, Genomic, and Cognitive Mediation of Vulnerability to Excessive Drinking in Monkeys"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Impaired Brain Reward Circuitry May Underlie Alcohol Drinking in a Rat Model of Schizophrenia and Co-Occurring Alcohol Use Disorder"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"From Mice to Men: Developing the Medial Prefrontal Cortex as a Translationally-Derived Biomarker for TMS Treatment Development"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"A Cortical Circuit Regulating Resilience to Compulsive-Like Alcohol-Seeking"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Social Isolation Stress Increases Kappa Opioid Receptor Sensitivity in the Nucleus Accumbens of Rats"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of the Cerebellum in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Alcohol and Behavioral State-Dependent Cerebellar Circuit Activity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Two Faces of the Cerebellum in Alcoholism: Site of Damage and Source of Compensation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Reward Signaling in Cerebellar Granule Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Genetic Variation in Potentially Rewarding and Aversive Actions of Low [EtOH] in the Cerebellum"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Neurocircuitry of Motivated Behaviors
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Role of Oxytocin in Alcohol Reinforced Behaviors in Rats and Humans"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"From Humans to Mice: A Link Between Low Striatal D2 Receptors and the Stimulant and Sedative Effects of Ethanol"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Mapping Neural Circuits Important for Alcohol Reward Memories in Drosophila "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"The Role of Top-Down and Bottom-Up Neural Circuits in the Modulation of Binge Drinking"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Regulation of Motivated Behavior by Phasic Dopamine"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"AMPA Receptor Subunit Activity Within the BLA to AcbC Circuit Is Required for the Positive Reinforcing Effects of Alcohol"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Frontiers: Immune/Microbiome/Inflammasome Interactions in Alcohol Use Disorder
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Neuroimmune Regulation of Alcohol Consumption: Which Cells? Which Signals?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Paradoxical and Sexually Dimorphic Effects of Adolescent Alcohol Exposure on Neuroimmune Function"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Biobehavioral Effects of a Pharmacological Challenge with Exogenous Ghrelin in Alcohol-Dependent Individuals: Is the Ghrelin System a Potential Pharmacological Target for Alcohol Use Disorder?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Implication of the Gut Microbiota in Behavioral Changes Linked to Alcohol Dependence: Mechanistic Approaches and Therapeutic Perspectives"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure