Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Alcohol Abuse and Addiction from Mice to Humans
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"Decoding Neuromodulatory Circuits in Motivated Behaviors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 9:20 pm
"50 Years of Neuroscience Research at NIAAA: From Membranes to Microcircuits (Allosterism, Hyperkatifiea and Allostasis)"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neuropeptide Signaling in Alcohol-Related Behaviors
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Alcohol Adaptations of Stress Circuits and Impact on Motivation, Intake and Relapse"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"CeA Neurotensinergic Neurons in Alcohol Consumption"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Central Amygdala Somatostatin Selectively Reduces Binge-Like Ethanol Intake"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Role of Neuropeptides in Stress-Enhanced Alcohol Drinking and Relapse-Like Behavior"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Central Amygdala Dynorphin/Kappa Opioid Regulation of Alcohol Drinking"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"What's Driving Escalation of Alcohol Drinking? Evidence in Favor of the Crystallization Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An Insular-BNST Circuit Regulates Negative Affect Associated with Stress and Alcohol Abstinence"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interoceptive Processing in Alcohol-Seeking
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Contribution of Insular Extracellular Matrix to Compulsive Alcohol Drinking"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Defining the Social in Models of Social Aspects of Alcohol Drinking and Dependence"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Interoceptive Effects of Low Dose Alcohol"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of Adolescent Alcohol Exposure on Nociception and Amygdala Neurotransmission"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Synaptic Plasticity in Making and Breaking Alcohol-Related Behaviors
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Molecular Mechanisms of Forgetting"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Persistent Reduction of Alcohol-Drinking Behavior by Optogenetic Induction of Corticostriatal Synaptic Plasticity in the Dorsomedial Striatum"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Knock-in Mice Expressing an Ethanol-Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dorsal Striatal Inhibitory Microcircuit Plasticity Underlying Compulsive Alcohol Drinking"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Prenatal Ethanol Exposure Leads to Failure of Synaptic Maturation and Persistent Cognitive/Behavioral Deficits"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Synaptic Fingerprints of Alcohol's Effects on Dorsal Striatal Glutamatergic Transmission"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol Use Disorders and Endocannabinoid Signaling
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Losing Balance: Dysregulated Endocannabinoid Signaling in Stress and Addiction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Targeting Endocannabinoid Synthesis to Reduce Alcohol Consumption"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Genetic Variants in the Endocannabinoid Pathway Are Associated with Sleep-Related Phenotypes in Alcohol Use Disorders"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Brain Imaging of Endocannabinoid Metabolism in Alcohol Use Disorder: PET Studies of the FAAH Probe [11-C]CURB"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Monitoring and Modulating the Brain: New Tools Focusing on Catecholamines
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"A Cortical-Brainstem Circuit Predicts and Governs Compulsive Alcohol Drinking"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Computational Approaches to Visualizing Cortical Activity States in Alcohol Drinking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Developmental Disruption of Locus Coeruleus-Norepinephrine Signaling Results in Phenotypes Relevant to Neurodevelopmental Disorders"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Preclinical and Clinical Evidence of Progressive Microstructural Damage, Altered Extracellular Space, and Dopamine Diffusion in Early Abstinence"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"A Novel Computational Framework for the Role of Dopamine in Learning and Memory"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"To Drink or Not(ch) to Drink: Molecular Mechanisms Through Which Alcohol Influences Memory in Drosophila "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress-Alcohol Interactions in the Control of Behavior
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Interactions of Stress and Alcohol Exposure in Kappa Opioid Receptor Mediated Anxiety-Like Behavior and Dopamine Dynamics in the Nucleus Accumbens"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Synaptic Changes Within the Rhesus Putamen that May Underlie a Bias Towards Sensory-Motor Action Patterns: Potential Role of Glucocorticoid Receptors"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Functional Dissection of Basolateral Amygdala Neural Circuits for Alcohol Seeking Behaviors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Identifying Functional Roles for Specific Neuropeptides and GABA Expressed in CRF Neurons of the Central Amygdala"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Cortical Function and Dysfunction in Compulsive Alcohol Seeking
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Manipulating Corticostriatal Circuits to Curtail Reward-Related Behaviour"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Neural Encoding in Medial Prefrontal Cortex During Aversion Resistant Drinking in Rodent Models of Alcohol Use Disorder"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Adolescent Alcohol Exposure Enhances Perineuronal Nets in the Medial Prefrontal Cortex and Impairs Fear Extinction Learning in Adulthood"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Oops... I Did It Again: Promising Cortical Targets for Decreasing Risky Drinking and Relapse with Transcranial Magnetic Stimulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Differential Engagement of the Dorsomedial Prefrontal Cortex and the Mediodorsal Thalamus During Alcohol Consumption"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"mTORC1 in the Orbitofrontal Cortex Contributes to Alcohol Seeking and Habit"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Involvement of Fronto-Cortical Sigma-1 Receptors in Alcohol-Induced Hyperalgesia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Signals Controlling Alcohol Intake
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Live Cell-Seq: A New Tool for Alcohol Study"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Alcohol Alters Exosome Content: Implications for the Neuroimmune Actions of Alcohol"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ethanol Modulation of Glutamate Presynaptic Function: Mechanisms and Consequences"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Under the Influence: How Ethanol Hijacks RNA-Binding Proteins to Change the Synaptic Landscape"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure