Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Methods for Increased Precision in the Genetic Analysis of Circuits and Behavior in Substance Use Disorders
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"“Lumping” versus “Splitting”: The Future of Translational Neuroscience in Alcohol Addiction"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Advances in the Resolution of Cell Types and Gene Function in the Neural Circuitry of Motivation"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alcohol Tolerance: Insights and Model Systems
9:00 am - 9:25 am
"Unraveling the Heterogeneity and Etiology of Alcohol Use Disorder Using the Addictions Neuroclinical Assessment Framework"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"A Transcriptional Program Regulating Synapse Number Mediates Alcohol Tolerance"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Hedonic Tolerance and Locomotor Tolerance: Two Novel Forms of Alcohol-Induced Tolerance in Drosophila "
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Long-Chain Ω-3 Polyunsaturated Fatty Acid Eicosapentaenoic Acid Modulates the Development of Acute Functional Tolerance to Ethanol"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Memory-Like States Created by the First Ethanol Experience"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Looks Can be Deceiving: Using a Preclinical Model to Study Tolerance to the Aversive Properties of Ethanol"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol-Induced Negative Affect and Withdrawal
7:30 pm - 7:50 pm
"Sleep Disturbance and Negative Emotionality in Individuals with Alcohol Use Disorder"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"MDMA-Assisted Pharmaco-behavioral Suppression of Cue-Induced Relapse Following Abstinence: Molecular Correlates and Translational Horizons"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Alternative Splicing Regulation During Alcohol Withdrawal"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Insular Somatostatin Interneurons Receive Ethanol-Inhibited Excitatory Input from the Motor Cortex and Buffer Affective Behaviors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Exploring Extended Amygdala Dynamics in Alcohol Related Behaviors"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol Incentive Salience and Motivated Behavior
9:00 am - 9:25 am
"The Central Nucleus of the Amygdala and the Pursuit of Alcohol"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"One Episode of Visually Signaled Sips of Alcohol Changes Human Brain Responses to the Visual Signal"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Serotonin Signaling and Reward Behavior Following Adolescent Alcohol Exposure"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Circuit Mechanisms Underlying Approach-Avoidance Conflict in Ethanol Self-Administration"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Midbrain Mechanisms Underlying Aversion-Resistant Alcohol Seeking and Consumption Elicited by Alcohol Cues"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Consideration of Peripheral Cues in Alcohol Interoceptive Effects"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advanced Techniques for Human and Non-Human Primate Alcohol Research
7:30 pm - 7:55 pm
"Imaging Molecular Targets of Interest with PET: Applications to Alcohol Use Disorder"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Transcranial Magnetic Stimulation for Alcohol Use Disorder: Learning from the Brain to Influence Behavior"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Genetic Risk for AUD Increases Ethanol Sensitivity in Human iGlutamate Neurons"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Bidirectional Manipulation of the Macaque Putamen Using DREADDs: Effects on Cognitive Function and Drinking"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Marmosets as Nonhuman Primate Research Models"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neural Bases of and Contributors to Increased Alcohol Consumption
9:00 am - 9:25 am
"FgFR1 Signaling in PKCd+ Central Amygdala Neurons Drives Compulsive Alcohol Use"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of Alcohol Action in the Brain by TMEM132B"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Alcohol Disruption of a Cortico-Claustro-Cortical Circuit Mediates Impaired Cognitive Flexibility"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Role of Parasubthalamic Crh Neurons in Alcohol Drinking Escalation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"A Role for Steroid Hormone Dysregulation Across the Liver-Brain Axis in Alcohol Consumption"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Cognitive, Genomic and Endocrine Risk Factors for Chronic Heavy Drinking in Rhesus Monkeys"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol Effects on Cortical and Striatal Circuits and Cognitive Function
7:30 pm - 7:50 pm
"Chronic Alcohol Impacts on Cognitive Flexibility and Prefrontal Function"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Dual Engram Ensembles in Striatal dMSNs Differentially Regulate Alcohol Relapse and Extinction"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Dissecting Cortical Valence Ensembles and Dopamine Receptor Type 1 Neuron Activity Encoding Bouts in Freely Moving Mice"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Noisy Exploration as a Phenotype for Hazardous Drinking in Youth"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"New Kids on the Block - Corticostriatal Axon Plasticity in Learning and Memory"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Alcohol-Related Neuro-Immune and Glial Involvement
9:00 am - 9:25 am
"Chronic Intermittent Alcohol Rewires Serotonergic Circuits in the Brain that Orchestrate Social Behavior"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Astrocyte Neuroimmune Activation by Ethanol"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Decoding Neuroimmune Pathway Involvement in Voluntary Alcohol Consumption with Single Cell Transcriptomics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Circuit Mechanisms Contributing to Astrocyte Modulation of Alcohol-Related Behaviors"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Males are More Susceptible to Maternal Immune Activation and Adolescent Alcohol Exposure: A Two-Hit Model of AUD Development"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Ethanol Disrupts Neuron–Microglia Crosstalk in Human iPSC-Derived Neural Models"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurobiology of Stress and Alcohol
7:30 pm - 7:50 pm
"The Insula Remembers: Linking Stress Reactivity and Negative Affect in Abstinence"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Dissecting the Functional Role of Basolateral Amygdala CRF Neurons in Stress and Alcohol Drinking"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Inhibition of Extended Amygdala CRF Neurons Attenuates Impacts of Early Life Stress on Alcohol Sensitivity and Voluntary Alcohol Drinking"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Neurokinin-1 Receptor Neurocircuitry in Alcohol Consumption Following Chronic Social Stress"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Old Dogs and New Tricks in the Search for Treatments to Reduce Escalated Alcohol Drinking after Stress"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure