Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Clinical Phenotypes in ALS and Related Motor Neuron Diseases
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:15 pm
"Neuroanatomic Neuropathologic Correlations with ALS Phenotypes"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Current and Future Therapeutic Interventions in SMA"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Accelerating Therapy Development: Master Platform Trial Initiatives and Subgroups"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Axonal Biology and Motor Neuron Loss
9:00 am - 9:25 am
"Nuclear Transport Receptors as Regulators of Protein Aggregation and Toxicity in ALS"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of Axonal Protein Synthesis by G3BP1 Aggregation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Axonal Transport Defects in iPSC-Derived Motor Neurons"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Surprising Link Between Lysosomal and RNA Biology in ALS Pathogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"ALS FUS Mutations Alter Splicing and Translation Through Loss and Gain of Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Decoding Motor Axon Biology in Health and ALS Using Axon-Seq"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of RNA Binding Proteins in Motor Neuron Degeneration
7:30 pm - 7:55 pm
"Therapy Development for Disease from TDP-43 Loss and/or Gain-of-Function"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Pathological TDP-43 Assemblies and Their Link to Disease Heterogeneity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"ALS and RNA: Thinking Outside the Nuclear Box"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Pathological Alterations of the Spinal Motor Neurons Induced by Optogenetic TDP-43 Oligomerization"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Phosphorylation Disrupts hnRNPA2 Aggregation and Alters Interactions with mRNA Transport Granule Components"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Aberrant RNA Metabolism
9:00 am - 9:25 am
"Production and Toxicity of Poly(GR) in C9ORF72-ALS/FTD"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Disassembly and Reassembly of the Nuclear Pore Complex in ALS/FTD"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Therapeutic Targeting of RNA in Spinal Muscular Atrophy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Molecular Mechanisms Controlling Localization and Phase Separation of ALS-Linked RNA-Binding Proteins"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Pathogenic Mutations in Gemin5 Cause Early-Onset Motor Dysfunction and Cerebellar Atrophy and Disrupt snRNP Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"ADAR2 Mislocalization and Widespread RNA Editing Aberrations in C9orf72-Mediated ALS/FTD"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Proteinopathies in Motor Neuron Disease
7:30 pm - 7:55 pm
"Cellular and Molecular Basis of Motor Neuron Demise: From SBMA to ALS"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Exploiting the Androgen Receptor Interactome to Identify Pathogenic Mechanisms in SBMA"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Protein Quality Control of Membraneless Organelles: Implications in ALS and Neurodegenerative Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Investigating the Mechanisms of UPF1-Mediated Rescue of TDP-43 Toxicity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"ALS-Implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Regeneration"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aberrant Protein Control and Related Mechanisms
9:00 am - 9:25 am
"The Nucleolus as a Protein Quality Control Compartment"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Role of the Autophagy Inducing Kinases, ULK1 and ULK2, in Degenerative Disorders"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Loss of Nuclear TDP-43 Function as a Mechanism of ALS Pathogenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Linking Selective Autophagy to Neurodegenerative Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Latest Insights from Amyloid Structures: Steric Zippers and LARKS in Fibrils"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The RNA Composition of Tau Aggregates in a Cellular Model of FTD"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Role of Neuroinflammation in Neurodegeneration
7:30 pm - 7:55 pm
"Three Subtypes of ALS: Retrotransposons, Stress and Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Microglial Toxicity and TDP-43 Proteinopathy in Neurodegeneration"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Role and Mechanism of RIPK1 in Mediating Neuroinflammation and Cell Death in ALS"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"C9orf72 Functions to Suppress Systemic and Neural Inflammation Induced by Gut Microbiota"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of Heterozygous Tbk1 Deletion in Old or Mutant SOD1 Transgenic Mice"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glial Biology of Motor Neuron Diseases
9:00 am - 9:25 am
"What Do Reactive Astrocytes (Actually) Do?"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Astrocyte Hemichannels as Conduits for Motor Neuron Death in ALS"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Stage Specific Control of Oligodendrocytes by TDP-43"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Glial Involvement in Synapse Loss in Alzheimer's Disease and ALS: Evidence from Human Post-Mortem Brain"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"C9orf72 Deficiency Promotes Microglial Mediated Synaptic Loss in Aging or Amyloid Accumulation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Using Patient-Derived Astrocytes to Inform Precision Medicine Approaches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Single Cell RNA Sequencing Uncovers Disease Associated Changes in the Population Structure of Human Microglia Specific to Amyotrophic Lateral Sclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Experimental Therapeutics and Biomarkers
7:30 pm - 7:55 pm
"The New Frontier of Spinal Muscular Atrophy: When, Where and How to Mitigate a Neurodegenerative Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"RNA-Targeted Mechanisms and Therapeutics for ALS"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Transforming Target Identification for Neurodegenerative Diseases: Proof of Concept in Synucleinopathies and Progress in ALS"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure