Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Genomic Discoveries in MND
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Defining the ALS "Mutome" to Inform Disease Mechanism and Target Identification"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Using Spatial Genomics to Identify Cellular Mechanisms of Cognitive Impairment in ALS-FTD"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Large-Scale Exome Analysis Reveals Rare Variant Contributions to ALS and Identifies Novel Risk Genes: What's Next?"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Long-Read Sequencing to Capture Genomic and Transcriptomic Signatures of ALS and Related Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Architecture of MND
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Molecular Visualization of TDP43 In Situ "
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Annexin A11 Aggregation in FTLD-ALS"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural Model for TDP-43 C-Terminal Domain Multimer Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dysfunctional RNA Metabolism
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Unraveling Epitranscriptomic and Epigenetic Dysfunctions in ALS"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Molecular Modifiers of TDP-43 Pathobiology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Role of Alternative Polyadenylation in ALS: From Mechanistic Pathways to Therapeutic Opportunities"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Dissecting the Molecular Determinants of FUS Function"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Non-Neuronal Contributions to MND
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Contribution of Astrocytes to C9orf72-Mediated Cortical Neurodegeneration"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Myelination and Neuroprotection by Oligodendrocytes"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Deciphering the Glial Functions of TDP-43"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Motor Neuron Degeneration Triggered by Blood–Spinal Cord Barrier Breakdown"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress and Stressors in MND
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Nuclear TDP-43 Condensation in Stress and ALS"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Endogenous Retroviruses Trigger, Sustain, and Propagate TDP-43 Protein Pathology"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"mRNA Regulation in Health and Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Next-Generation Human Neuromuscular Models to Study ALS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Defining TDP-43-Dependent Molecular Defects in CNS Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Working Well With Mice and Some New Mouse Models for ALS Research"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"TDP-43-Dependent Dysregulated Splicing: Novel Mechanisms and Unexpected Targets"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neural Circuits Relevant to MND
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Pathological Mechanisms Associated With Altered Excitability in ALS"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Brain Motor Function and the Pathophysiology of ALS"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"A Mouse Model of ALS Caused by Sphingolipid Dysregulation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Towards a TDP-43 LOF Blood Test for ALS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Biomarkers for ALS Therapy Development: Old Friends and New Acquaintances"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Peripheral Minimally Invasive Biomarkers of Early Disease in MND"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Therapeutic Strategies for MND
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Genetic and Pharmacological Screens Identify New Therapeutic Targets in ALS and FTD"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Exploring New Therapeutic Approaches for ALS and ALS/FTD"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Countering Deleterious Phase Transitions in ALS"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure