Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Discovery to Application
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"From the Discovery of the Cathelicidin LL-37 to Host-Directed Therapy Fighting Infections"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Many Therapeutic Applications of Host Defence/Antimicrobial Peptides: What Are the Big Issues?"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Unpredictable and Frequently Non-Rational Path from Discovery to Clinical Application"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Manipulating Mechanistic Discoveries to Maximize Microbicidal Activity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"From Nanotechnology to Antimicrobial Activity: The Role of Molecular Self-Assembly"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Ribosome-Targeting Short Peptides: Mode of Binding and Mechanism of Action"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Synergistic Effect Between Human Alpha Defensin and LL37 Characterized by Techniques in Biophysics"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Discovery of Next-Generation Antimicrobials Through Bacterial Self-Screening of Surface-Displayed Peptide Libraries"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Insights into Mechanisms of Antimicrobial and Antifungal Activity of Peptides Derived from Venom Toxins"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Development of PEGylated Antibacterial OligoTEA Prodrugs for Selective Activity Against Methicillin-Resistant Staphylococcus aureus "
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Harnessing a Frog-Derived Peptide as an Anti-Influenza Agent"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"The Antimicrobial Aftermath: How Immune Activation Is Regulated upon Cathelicidin-Mediated Killing of E. coli "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Master Regulators: Interplay Between Antimicrobial Host Defense Peptides and the Microbiome
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:20 pm
"The Gut Microbiota Prevents the Development of Autoimmune Diabetes via the Induction of Antimicrobial Peptides"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
"The Microbiota Programs Diurnal Oscillations in Intestinal Antimicrobial Protein Expression"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Biotherapy with AMP Producing Bacteria Inhibits Staphylococcus aureus and Improves Inflammation in Atopic Dermatitis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"The Role of Solitary Chemosensory Cells in Respiratory Innate and Adaptive Immunity: From Antimicrobial Peptides to Eosinophils"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Unanticipated Role of Antimicrobial Peptide in Behavioral Memory"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Treating Antimicrobial Resistant Infections and Biofilms with Antimicrobial Host Defense Peptides
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Novel Antimicrobial Peptides Eradicate Antimicrobial Resistant Bacteria, Biofilms and Persisters"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Bacteriophage-Derived Lysins Engineered to Exert a Rapid and Potent Bactericidal Effect Against Pseudomonas aeruginosa "
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Pharmaceutical Antibiotics and Endogenous Antimicrobial Peptides: A Cooperative Partnership Important in Successful Treatment Outcomes of Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Phylogenetic Barriers to Horizontal Transfer of Antimicrobial Peptide Resistance Genes in the Human Gut Microbiota"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Cathelicidin Is a 'Fire Alarm', Generating Protective NLRP3-Dependent Airway Epithelial Cell Inflammatory Responses During Infection with Pseudomonas aeruginosa "
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Rigidification of the E. coli Cytoplasm by the Human Antimicrobial Peptide LL-37 Revealed by Superresolution Fluorescence Microscopy"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Novel Insights in the Mode of Action of Antifungal Plant Defensins and Their Effect on Fungal Biofilms"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Insights into the Mechanism of Action of PepR, a Viral-Derived Peptide, Against Staphylococcus aureus Biofilms"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Antimicrobial Host Defense Peptides in the Treatment and Diagnosis of Global Infection Challenges
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Induction of Antimicrobial Host Defense Peptides as a Therapeutic Strategy Against Tuberculosis"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"What Have We Learned from Metal-Binding AMPs? Targeting Intracellular Mycobacterium tuberculosis "
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Efflux Pump-Mediated AMP Resistance in Neisseria gonorrhoeae : A Little Bit of Help from Commensal Friends"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Marine Antimicrobial Peptides: Therapeutics for Visceral Leishmaniasis"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Aroylated Phenylenediamines (APDs): Novel Inducers of Innate Immunity for Host Directed Therapy Against Infections"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploiting Mechanistic Knowledge to Utilize Immunomodulatory Activities
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Evidence for Defensin Involvement in Metabolic Regulation and Obesity"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Reactive Adipogenesis: The Last, First Line of Defense by Antimicrobial Peptides"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Deimination, as a Mechanism of Cathelicidin Function Control"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Human Beta-Defensin 2 Is Effective in the Treatment of Experimental Colitis and Is Reversibly Modulating Microbiome Diversity"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"The Function of Host Defense Peptides in Immunomodulation and Innate Memory"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Peptides as Anti-Inflammatories"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Balanced Expression of Yin/Yang Innate Immune Peptides, LL-37 and ABeta, May Prevent Alzheimer's Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cathelicidin-Related Antimicrobial Peptide Protects Against Ischemia Reperfusion-Induced Acute Kidney Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Antimicrobial Host Defense Peptide Impact on Cancer and Adaptive Immune Responses
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Antimicrobial Peptides in Immunity and Autoimmunity"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
"Cathelicidin-Related Antimicrobial Peptide Limits Gluten-Sensitive Enteropathy"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"LL-37-Mediated Generation of Immunotherapeutic Dendritic Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"How Cells Gain Resistance to the Action of Anticancer Lytic Peptides"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Transgenic Mice Overexpressing PG1 Display Corneal Opacity and Severe Inflammation in the Eye Without Changes in Immune Cell Population Sizes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Realizing the Potential of Antimicrobial Host Defense Peptides: From Design to Clinical Use
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Toward Computer-Guided Design and Discovery of Novel Antimicrobial Peptides"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Disruption of the Central Hydrophobic Region Mitigates the Anti-Inflammatory Activity of an Innate Defence Regulator (IDR) Peptide, but Not the Ability to Improve Lung Function"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"PEG-Based Peptidomimetics and Prodrugs of Antimicrobial Peptides for Clinical Use"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Research, Design and Clinical Testing of an Antimicrobial Peptide-Coated Contact Lens"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"The Development Pathway for Clinical Stage Novel Antibacterial and Antifungal Peptides"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Plant Defensin HXP124 as a Safe and Effective Treatment for Fungal Nail Infections"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"An Antimicrobial Peptide-Rich Platelet-Derived Biologic Exhibits Anti-Biofilm, Anti-Inflammatory and Chondroprotective Properties in an Equine Infectious Arthritis Model"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Development of Membrane Selective Stapled Antimicrobial Peptides to Combat Multidrug Resistant Gram Negative Pathogens"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mining Peptide Diversity and Functionality Across Species
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Inspired by Nature: Learning from AMPs in Their Natural Context to Avoid Resistance"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
"How to Control Pseudomonas aeruginosa -Induced Pneumonia? A Lesson from the Amphibian Skin Derived Peptide Esculentin(1-21) and Its Diastereomer"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
"Synergy and Remarkable Specificity of Antimicrobial Peptides In Vivo Using a Systematic Knockout Approach"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Exploring Ancestral Traits Lost During Molecular Evolution of Big-Defensins Towards β-Defensins"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Investigating Plant Derived Antimicrobial Peptides Using 'PepSAVI-MS'"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure