| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | The meaning of death: role of apoptotic cell clearance in shaping the immune response |
| Discussion Leader: Martin Herrmann (University of Erlangen-Nuremberg, Germany) |
| 3:45 pm - 4:15 pm | Matthew L. Albert (Institut Pasteur, INSERM, France)
"Defining the role of cell death in antigen cross-presentation and dendritic cell activation" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | To eat or not to eat: mechanisms of recognition and uptake of apoptotic cells |
| Discussion Leader: Sandra Franz (Max Bürger Research Center, Germany) |
| 7:30 pm - 7:50 pm | Matthias Zirngibl (University of Erlangen-Nuremberg, Germany)
"Redistribution and clearance of organelles during apoptosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Arnaud Millet (Institut Cochin, France)
"Membrane expression of proteinase 3 at the membrane of apoptotic neutrophil is essential for impairing their phagocytosis by macrophages" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Christina Janko (University of Erlangen-Nuremberg, Germany)
"Release of glycerophosphocholine discriminates secondary from primary necrosis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jorine Willems (University of Edinburgh, UK)
"Phagocyte activation by soluble and microparticle-associated chemoattractant signals released from apoptotic lymphoma cells" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | To eat or not to eat: consequences of successful or failed apoptotic cell uptake |
| Discussion Leader: Michael R. Elliott (University of Rochester, USA) |
| 9:00 am - 9:20 am | Stefan Uderhardt (University of Erlangen-Nuremberg, Germany)
"12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunological tolerance" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ricardo Chaurio (University of Erlangen-Nuremberg, Germany)
"In vivo apoptosis induction of tumor cells using a conditional suicide switch of human tBid cause tolerance in an allogeneic tumor" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Agnieszka Kaczmarek (VIB-DMBR University of Ghent, Belgium)
"TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation and contribute to severity of doxorubicin- induced intestinal damage" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Michael Fricker (University of Cambridge, UK)
"Inhibition of PS/MFG-E8 eat-me signaling prevents neuronal death in models of inflammatory-mediated neurodegeneration" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:45 pm | Lessons from model systems |
| Discussion Leader: Nathalie Franc (Scripps Research Institute, USA) |
| 1:30 pm - 1:50 pm | Francesca Peri (European Molecular Biology Laboratory, Germany)
"Neuronal cell death goes live: how do phagocytes detect dying neurons in the living zebrafish brain" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:30 pm | Michael R. Elliott (University of Rochester, USA)
"Mixed signals: sorting out the cues released by dying cells and their impact on clearance and inflammation" |
| 2:30 pm - 2:45 pm | Discussion |
| 2:45 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
