| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | NUCLEAR RECEPTORS AND COREGULATORS |
| Discussion Leader: Johan Auwerx (IGBMC, France) |
| 7:40 pm - 8:05 pm | Johan Auwerx (IGBMC, France)
"Coregulators in the control of energy expenditure" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Peter Tontonoz (University of California, Los Angeles)
"Control of lipid metabolism and immunity by LXRs" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Jorge Plutzky (Brigham and Women's Hospital)
"Endogenous mechanisms of PPAR modulation" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Short Talk: Serena Ghisletti (University of California, San Diego)
"Anti-inflammatory mechanisms of LXRs and PPARs" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | INNATE AND ACQUIRED IMMUNE MECHANISMS |
| Discussion Leader: Goran Hansson (Karolinska Institute, Sweden) |
| 9:00 am - 9:25 am | Goran Hansson (Karolinska Institute, Sweden)
"Vascular immune activation - impact on metabolism and plaque stability" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Joseph Witztum (University of California, San Diego, USA)
"Oxidation-Specific Epitopes are a Major Target of the Humoral Component of Innate Immunity" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break / Group Photo |
| 10:40 am - 11:05 am | Ziad Mallat (Centre de Recherche Cardiovasculaire Lariboisiere, France)
"Regulatory T Cells: New Players in Atherosclerosis" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Linda Curtiss (The Scripps Research Institute, USA)
"Toll-like Receptors and Innate Immunity in Atherosclerosis" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Short Talk: To be chosen from Abstracts and Posters |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | GENETICS |
| Discussion Leader: Helen Hobbs (University of Texas, Southwestern Medical Center) |
| 5:30 pm - 5:55 pm | Alan Attie (University of Wisconsin)
"Diabetes Gene Discovery through Genetic and Genomic Approaches" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:30 pm | Jake Lusis (University of California, Los Angeles)
"Integrating genetic and genomic data: Application to complex cardiovascular traits" |
| 6:30 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:05 pm | Steve Young (University of California, Los Angeles)
"A new paradigm for the clearance of chylomicrons from the plasma" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:30 pm | Short Talk: Dov Shiffman (Celera, USA)
"Association of Gene Variants with Incident Myocardial Infraction in the Cardiovascular Health Study" |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADVANCED PLAQUE: DEATH, DISRUPTION, THROMBOSIS AND CALCIFICATION |
| Discussion Leader: Peter Libby (Brigham and Women's Hospital, USA) |
| 9:00 am - 9:25 am | Garret FitzGerald (University of Pennsylvania, USA)
"Novel mouse models of eicosanoid metabolism" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Alain Tedgui (Hôpital Lariboisiere, France)
"Defective clearance of apoptotic cells accelerates atherosclerosis" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Peter Libby (Brigham and Women's Hospital, USA)
"Extracellular Matrix Remodeling in Atherothrombosis" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Linda Demer (University of California, Los Angeles)
"Self-Organization and Osteogenic Differentiation in Vascular Calcification" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Short Talk: Tracie Seimon (Columbia University, USA)
"Induction of macrophage death by combinatorial pattern recognition receptor signaling" |
| 12:10 pm - 12:30 pm | Short Talk: To be chosen from Abstracts and Posters |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | IMAGING |
| Discussion Leader: Chun Yuan (University of Washington, USA) |
| 5:30 pm - 5:55 pm | Chun Yuan (University of Washington, USA)
"Magnetic Resonance Imaging for Plaque Characterization" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:30 pm | Zahi Fayad (Mount Sinai School of Medicine, USA)
"Multimodality (MR, PET, CT) for Atherosclerotic plaque imaging and differentiation: from anatomy to molecules" |
| 6:30 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:05 pm | Sam Tsimikas (University of California, San Diego, USA)
"Molecular Imagin" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:30 pm | Short Talk: To be chosen from Abstracts and Posters |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MACROPHAGE BIOLOGY AND INFLAMMATION |
| Discussion Leader: Alan Aderem (Institute of Systems Biology, USA) |
| 9:00 am - 9:25 am | Alan Aderem (Institute of Systems Biology, USA)
"A systems approach to dissecting immunity" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Siamon Gordon (University of Oxford, UK)
"Macrophage receptors - the link between innate immunity and lipid homeostasis" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Isreal Charo (University of California, San Francisco)
"Chemokine receptors in atherosclerosis and monocyte egress from the bone marrow" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Kathryn Moore (MGH, Harvard Medical School, USA)
"Identification of a novel regulator of macrophage and smooth muscle cell migration in atherosclerosis" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Short Talk: Paul Fox (Cleveland Clinic, USA)
"Translational Control of Inflammatory Gene Expression in Monocytic Cells" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | VASCULAR CELL SOURCES AND PHENOTYPES |
| Discussion Leader: Seppo Yla-Hertulla (University of Kuopio, Finland) |
| 5:30 pm - 5:55 pm | Seppo Yla-Hertulla (University of Kuopio, Finland)
"Vascular cells and growth factors in atherogenesis and angiogenesis" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:30 pm | Gwendalyn Randolph (Mount Sinai School of Medicine, USA)
"Monocyte subpopulations and atherosclerosis" |
| 6:30 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:05 pm | Stefanie Dimmeler (J.W. Goethe University, Frankfurt, Germany)
"Endothelial progenitor cells: impact on atherosclerosis" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:30 pm | Short Talk: To be chosen from Abstracts and Posters |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LIPID METABOLISM AND REVERSE CHOLESTEROL TRANSPORT |
| Discussion Leader: Alan Tall (Columbia University, USA) |
| 9:00 am - 9:25 am | Alan Tall (Columbia University, USA)
"The role of HDL and ABCG1 in macrophage cholesterol efflux and atherosclerosis" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Carl Sparrow (Merck Research Laboratories, USA)
"Mechanistic insights into the degradation of the LDL receptor by PCSK9" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Rudolph Zechner (University of Graz, Austria)
"Lipolysis: novel aspects in adipose and non-adipose tissues" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Tobias Walther (Max-Plank Institute for Biochemistry)
"The Cell Biology of Lipid Storage: New Players in Lipid Duoplet Biogenesis" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Short Talk: To be chosen from Abstracts and Posters |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | DIABETES AND METABOLIC SYNDROME |
| Discussion Leader: Bart Staels (France) |
| 5:30 pm - 5:55 pm | Bart Staels (France)
"Nuclear receptors controlling the metabolic syndrome" |
| 5:55 pm - 6:05 pm | Discussion |
| 6:05 pm - 6:30 pm | Takashi Kadowaki (University of Tokyo, Japan)
"Adiponeotin and adiponectin receptors" |
| 6:30 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:05 pm | Godfrey Getz (University of Chicago, USA)
"LIGHT on Lipoprotein Homeostasis" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:30 pm | Short Talk: To be chosen from Abstracts and Posters |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
