Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Diabetes and Dyslipidemia in Atherosclerosis
7:40 pm - 8:05 pm
"Pivotal Role of Oxidized Phospholipids in NASH and Atherosclerosis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Novel Mediators of Diabetes-Associated Atherosclerosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Diabetes and ApoC-III in Cardiovascular Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Lipodystrophy and the Role of SR-BI and PCPE2"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Triglyceride, Lipolysis and Vascular Disease"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Atlas of the Vascular and Immune Cell Repertoire in Health and Disease
9:00 am - 9:20 am
"Apolipoprotein B-Specific CD4 T Cells in Mouse and Human Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Exploring Regulators of Macrophage Heterogeneity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Systems Genetics of Endothelial Cell Activation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cell Populations and Disease Progression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Novel Cellular Drivers of Tissue Fibrosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Genetic Regulation of Human Vascular Smooth Muscle Cell Phenotypes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single Cell Sequencing of Adventitial Mesenchymal Cells from Healthy Mice Reveals Five Differentiation Tracks from a Common Progenitor Cluster and 6 MC-Specific Genes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Coding RNAs in Cardiovascular Disease
7:30 pm - 7:45 pm
"Decoding the Non-Coding Regulatory Pathways of Vascular Inflammation"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Non-Coding RNA Regulation of Plaque (De)stabilization"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"MicroRNA Regulation of Atherosclerosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"LncRNAs in Vascular Pathobiology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Enhancer-Associated LncRNA in Endothelial Homeostasis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"MicroRNA Therapies to Reduce Atherosclerosis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Macrophage Death and Resolution of Inflammation in Atherosclerosis
9:00 am - 9:20 am
"Smooth Muscle Cell Efferocytosis in Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Necrotic Death in the Vessel Wall: Things Aren't Always as They Seem"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Amino Acid Metabolism in Macrophages in Efferocytosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Immunometabolic Resolution of MI by Macrophages"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Metabolic Rewiring of Macrophages in Atherosclerosis: A Sweet Balance Between Life and Death"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Increased Inflammasome Activation in Jak2v617f-Mediated Clonal Hematopoiesis Leads to Increased Macrophage Proliferation and Pyroptosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Macrophage-Derived 25-Hydroxycholesterol Orchestrates Vascular Inflammation and Plaque Remodeling in Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Interface of Immune and Metabolic Responses in Atherosclerosis
7:30 pm - 7:50 pm
"Revisiting LXRs as Therapeutic Targets in Cardiovascular and Metabolic Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Cholesterol Efflux Pathways, Leukocytes and Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Myeloid Cells in Cardiovascular Health"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Macrophage Exosomes in the Pathogenesis of Diabetic Atherosclerosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Caloric Restriction Promotes Atherosclerosis Resolution Independent of Plasma Cholesterol and Induces Enrichment of Phagocytic Macrophages in the Adipose Tissue"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endothelial Mechanotransduction, Metabolism and Lipoprotein Transport in Atherosclerosis
9:00 am - 9:20 am
"Endothelial Cell Regulation of Arterial Intimal Myeloid Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Metabolic Regulation of Endothelial Cell Phenotypes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Interface of Lipid Metabolism and Inflammation in the Vessel Wall"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Exploring Non-Canonical and Canonical VEGFR Signaling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Endothelial-Macrophage Interactions and Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Role of CD163 Macrophages in Vascular Calcification"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Smooth Muscle Cell Reprogramming and Clonality in Vascular Disease
7:30 pm - 7:50 pm
"Extracellular Vesicles as a Precursor of Microcalcification in Rupture-Prone Atherosclerotic Lesions"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Control of Smooth Muscle Cell Accumulation in Atherosclerosis Through Proliferation, Death and Cell Senescence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"SMC Clonal Expansion: A Common Theme in Vascular Pathologies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Bioenergetic Changes Underlie PDGFBR-Driven Atherosclerotic Lesion Stabilization by Vascular Cells"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate and Adaptive Immunity in Atherosclerosis
9:00 am - 9:20 am
"B Cells in Atherosclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"B-1b Cells Bridge Innate and Adaptive Protective Immunity in Atherosclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Immune Cell Lipid Signaling in Atherosclerosis and Post-Ischemic Cardiac Healing"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Pathways that Control ILC2 Atheroprotective Functions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Novel Strategies for Immunotherapy and Vascular Protection in Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"An IL23-IL22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet Induced Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Role of Regulatory T Cells in Atherosclerosis Regression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Novel Therapeutic Approaches and Diagnostic Tools for Atherosclerosis
5:30 pm - 5:45 pm
"Cardioimmuno-Imaging and Cardioimmuno-Therapy"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
"ATP-Citrate Lyase as a Target for Dyslipidemia and Atherosclerosis"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
"New Phenotypes for Stratification and Modeling of Atherosclerosis"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"Gene Editing to Prevent and Cure Metabolic Disorders"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"RNA Antisense Therapeutics for Cardiovascular Diseases"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Fishing for Regulators: Live Imaging of Intestinal Lipid Flux Through Lipoprotein and Lipid Droplets Using Zebrafish"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure