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Atherosclerosis

Gordon Research Conference

From Molecular and Cellular Insights to Therapeutic Approaches in Atherosclerosis

June 16 - 21, 2019

Chairs

and

Vice Chairs

and

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

This GRC on Atherosclerosis has been meeting for over 45 years! Over the past four decades, we have learned that atherosclerosis is a complex disease consisting of inflammatory, autoimmune, lipid, and vascular biology components. In this 2019 GRC, we want to take a fresh new look at each of these disease components. We plan to discuss and question the current dogmas about atherosclerotic disease progression, learn about new molecules and new cellular pathways that mechanistically play a role in atherosclerosis development, discuss how to utilize new high dimensional methods to study cellular and molecular components of the atherosclerotic plaque, and identify and discuss new clinical targets – all with the goals to treat, and ultimately prevent, atherosclerosis. Sessions on vascular biology, dyslipidemia, innate and adaptive immunity, noncoding RNAs, and novel therapies have been planned. Please join us in Sunday River, Maine in June 2019 to learn more on molecular and cellular insights and therapeutic approaches in atherosclerosis!

Related Meeting

This GRC will be held in conjunction with the "Atherosclerosis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Diabetes and Dyslipidemia in Atherosclerosis Discussion Leader:
7:40 pm - 8:05 pm	"Pivotal Role of Oxidized Phospholipids in NASH and Atherosclerosis"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Novel Mediators of Diabetes-Associated Atherosclerosis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Diabetes and ApoC-III in Cardiovascular Disease"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Lipodystrophy and the Role of SR-BI and PCPE2"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Triglyceride, Lipolysis and Vascular Disease"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Atlas of the Vascular and Immune Cell Repertoire in Health and Disease Discussion Leader:
9:00 am - 9:20 am	"Apolipoprotein B-Specific CD4 T Cells in Mouse and Human Atherosclerosis"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Exploring Regulators of Macrophage Heterogeneity"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Systems Genetics of Endothelial Cell Activation"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Cell Populations and Disease Progression"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Novel Cellular Drivers of Tissue Fibrosis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Genetic Regulation of Human Vascular Smooth Muscle Cell Phenotypes"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Single Cell Sequencing of Adventitial Mesenchymal Cells from Healthy Mice Reveals Five Differentiation Tracks from a Common Progenitor Cluster and 6 MC-Specific Genes"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Non-Coding RNAs in Cardiovascular Disease Discussion Leader:
7:30 pm - 7:45 pm	"Decoding the Non-Coding Regulatory Pathways of Vascular Inflammation"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Non-Coding RNA Regulation of Plaque (De)stabilization"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"MicroRNA Regulation of Atherosclerosis"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"LncRNAs in Vascular Pathobiology"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Enhancer-Associated LncRNA in Endothelial Homeostasis"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"MicroRNA Therapies to Reduce Atherosclerosis"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Macrophage Death and Resolution of Inflammation in Atherosclerosis Discussion Leader:
9:00 am - 9:20 am	"Smooth Muscle Cell Efferocytosis in Atherosclerosis"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Necrotic Death in the Vessel Wall: Things Aren't Always as They Seem"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Amino Acid Metabolism in Macrophages in Efferocytosis"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Immunometabolic Resolution of MI by Macrophages"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Metabolic Rewiring of Macrophages in Atherosclerosis: A Sweet Balance Between Life and Death"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Increased Inflammasome Activation in Jak2v617f-Mediated Clonal Hematopoiesis Leads to Increased Macrophage Proliferation and Pyroptosis"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Macrophage-Derived 25-Hydroxycholesterol Orchestrates Vascular Inflammation and Plaque Remodeling in Atherosclerosis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Interface of Immune and Metabolic Responses in Atherosclerosis Discussion Leader:
7:30 pm - 7:50 pm	"Revisiting LXRs as Therapeutic Targets in Cardiovascular and Metabolic Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Cholesterol Efflux Pathways, Leukocytes and Atherosclerosis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Myeloid Cells in Cardiovascular Health"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Macrophage Exosomes in the Pathogenesis of Diabetic Atherosclerosis"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Caloric Restriction Promotes Atherosclerosis Resolution Independent of Plasma Cholesterol and Induces Enrichment of Phagocytic Macrophages in the Adipose Tissue"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Endothelial Mechanotransduction, Metabolism and Lipoprotein Transport in Atherosclerosis Discussion Leader:
9:00 am - 9:20 am	"Endothelial Cell Regulation of Arterial Intimal Myeloid Cells"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Metabolic Regulation of Endothelial Cell Phenotypes"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Interface of Lipid Metabolism and Inflammation in the Vessel Wall"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Exploring Non-Canonical and Canonical VEGFR Signaling"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Endothelial-Macrophage Interactions and Atherosclerosis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"The Role of CD163 Macrophages in Vascular Calcification"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Smooth Muscle Cell Reprogramming and Clonality in Vascular Disease Discussion Leader:
7:30 pm - 7:50 pm	"Extracellular Vesicles as a Precursor of Microcalcification in Rupture-Prone Atherosclerotic Lesions"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Control of Smooth Muscle Cell Accumulation in Atherosclerosis Through Proliferation, Death and Cell Senescence"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"SMC Clonal Expansion: A Common Theme in Vascular Pathologies"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Bioenergetic Changes Underlie PDGFBR-Driven Atherosclerotic Lesion Stabilization by Vascular Cells"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Innate and Adaptive Immunity in Atherosclerosis Discussion Leader:
9:00 am - 9:20 am	"B Cells in Atherosclerosis"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"B-1b Cells Bridge Innate and Adaptive Protective Immunity in Atherosclerosis"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Immune Cell Lipid Signaling in Atherosclerosis and Post-Ischemic Cardiac Healing"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"New Pathways that Control ILC2 Atheroprotective Functions"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Novel Strategies for Immunotherapy and Vascular Protection in Atherosclerosis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"An IL23-IL22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet Induced Atherosclerosis"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Role of Regulatory T Cells in Atherosclerosis Regression"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Novel Therapeutic Approaches and Diagnostic Tools for Atherosclerosis Discussion Leader:
5:30 pm - 5:45 pm	"Cardioimmuno-Imaging and Cardioimmuno-Therapy"
5:45 pm - 5:50 pm	Discussion
5:50 pm - 6:05 pm	"ATP-Citrate Lyase as a Target for Dyslipidemia and Atherosclerosis"
6:05 pm - 6:10 pm	Discussion
6:10 pm - 6:25 pm	"New Phenotypes for Stratification and Modeling of Atherosclerosis"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:45 pm	"Gene Editing to Prevent and Cure Metabolic Disorders"
6:45 pm - 6:50 pm	Discussion
6:50 pm - 7:05 pm	"RNA Antisense Therapeutics for Cardiovascular Diseases"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	"Fishing for Regulators: Live Imaging of Intestinal Lipid Flux Through Lipoprotein and Lipid Droplets Using Zebrafish"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13HL147517-01 from the National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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