Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Lipids and Inflammation
7:40 pm - 8:05 pm
"Novel Insights Relating Inflammation to Aging and Longevity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Clonal Hematopoiesis, Inflammasomes and Atherosclerosis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Molecular Signatures of Atherosclerosis Regression"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Plasticity and Clonality in Atherosclerosis
9:00 am - 9:20 am
"Clonal Hematopoiesis in Atherosclerosis: Expanding Clones, Expanding Risk"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Vascular Smooth Muscle Cell Heterogeneity in Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Fibroblast Identity, Origin, Fate and Function in Ageing and Atherosclerosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dissecting Atherosclerotic Calcification: Unveiling the Role of Extracellular Vesicles and Microcalcification in Plaque Rupture"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dissecting Human Atherosclerosis with Multi-Omics Approaches"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dissecting Antigen-Specific T Cell-Responses in Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Atherosclerosis and Immunology: Translational Progress
6:00 pm - 6:20 pm
"Targeting Adaptive Immunity in Patients with Atherosclerotic Cardiovascular Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Genetic Regulation of Innate-like B Cells in Atherosclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Uncovering Atherosclerotic CVD by PET Imaging"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Deciphering Innate and Adaptive Immune Cell Responses in AMI Patients with Plaque Erosion and Rupture"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomics, Genetics, and Bioinformatics in Atherosclerosis
9:00 am - 9:20 am
"Clonal Hematopoiesis and Coronary Artery Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Decoding Vascular Disease using Human Genetics and Single-Cell Omics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Using Genomics to Unravel the Cardiovascular Component of Dementia"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Exploring the Genetic Basis of Atherosclerosis with Single-Cell, Spatial, and Functional Genomics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Translating Genetic Information into Clinical Decision Making"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Decoding Atherosclerosis: Macrophages and Their Subsets as Predictors of Cardiovascular Risk"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Immune-Checkpoint Inhibitors: Insights into Cardiovascular Biology"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Cancer Therapy Cardiotoxicity Due to Endothelial Damage, Vascular Inflammation and Plaque Rupture"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Defining the Underpinnings of Immune Responses to Checkpoint Myocarditis across Heart, Blood and Tumor"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Reverse Cardio-Oncology: Mechanisms Driving Tumor Growth After Myocardial Infarction"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation, Immunity and Atherosclerosis: Basic Mechanisms
9:00 am - 9:20 am
"The Spatial Odyssey of the Human Atherosclerotic Plaque"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Controlling Endothelial and Immune Cell Homeostasis in Atherosclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Targeting Trem2+ Foam Cells in Atherosclerosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Loss of Tolerance to ApoB in Atherosclerosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Sex Differences in the Immune Response Impact Cardiovascular Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Emerging Mosquito-Borne Viruses as Environmental Stressors to Cardiovascular Health"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Neuro-Vascular Axis and the Role of Environmental Stressors in Atherogenesis
6:00 pm - 6:20 pm
"Lifestyle and Heart-Brain Communication"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Neuro-Vascular-Immune Interactions in Aging"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Cardiogenic Regulation of Sleep in Cardiovascular Disease"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"From Pollution to Prevention: The Environmental Roots of Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Lipid Metabolism and its Translation
9:00 am - 9:20 am
"Cholesterol Efflux: From Pathophysiology to Therapeutic Advances"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Metabolism and Atherogenicity of Triglyceride-Rich Lipoproteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"RAGE/DIAPH1: Roles in Atherosclerosis Through Modulation of Mitochondrial Function and Actin Cytoskeleton Dynamics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Macrophage Phospholipid Metabolism in Vascular Inflammation and Atherosclerosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Paradox of LIPA in Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Microbial Metabolites in the Progression of Atherosclerosis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Smart Drugs, Gene Therapy and Biomarkers
6:00 pm - 6:30 pm
"Overcoming Obesity: The Discovery of Multi Receptor Drugs"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:10 pm
"Discovery and Pharmacological Targeting of Pathways that Contribute to Residual Cardiovascular Risk"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:50 pm
"Towards Developing a One-Time Gene Editing Treatment for a Lifetime of Cholesterol-Lowering Benefit"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure