Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Crosstalk Between Vascular and Neural Cells
Discussion Leader: Sidar Aydin (University of California San Diego, United States)
3:45 pm - 4:20 pm
Carmen Ruiz de Almodovar (University of Bonn, Germany)
"Formation and Function of Blood Vessels in the Spinal Cord: From Development to Disease"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insights Into the Physiology of CNS Barriers
Discussion Leaders: Leon Smyth (Washington University in St. Louis, United States) and Laura Gonzalez Gonzalez (Kellogg Eye Center, University of Michigan , United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Min Joung Lee (Chungnam National University College of Medicine, South Korea)
"Mitochondrial Respiration in Endothelial Cells is Essential for Maintaining Blood-Brain Barrier Integrity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Adesewa Akande (Louisiana State University Health Sciences Center Shreveport, United States)
"Increased Neurovascular Permeability and Decreased Neurovascular Density in Neurogranin Knockout Mice"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Daniel Chavarria (Vanderbilt University, United States)
"The Effects of Laminar and Pulsatile Shear Stress on Brain Microvascular Endothelial Cell Function"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Inyoung Jeong (Jung) (Norwegian University of Science and Technology (NTNU), Norway)
"The Evolutionarily Conserved Choroid Plexus Sustains the Homeostasis of Brain Ventricles in Zebrafish"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Nagela Ghabdan Zanluqui (National Institutes of Health, United States)
"Venous Plexus-Associated Lymphoid Hubs Support Meningeal Humoral Immunity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
CNS Barriers in Neurological Disease
Discussion Leaders: Milda Girdenyte (Uppsala University, Sweden) and Brent Kisby (Texas Tech University Health Sciences Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Marie-Lynn Cuypers (KU Leuven, Belgium)
"Behind the Barrier: How to Extend the Half-Life of Biologicals in the Brain?"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Fruzsina Walter (HUN-REN Biological Research Centre, Szeged, Hungary, Hungary)
"Development of a Novel Human Cell-Based Blood-Brain Barrier and Midbrain Organoid Lab-on-a-Chip Model"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Bartosz Laczek (Aalborg Universitet, Denmark)
"Viral Gene Therapy at the Blood-Brain Barrier as a Strategy to Enable Protein Secretion from Endothelium to the Brain"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Celene Titus (University of Toronto, Canada)
"Anti-Viral and Anti-Inflammatory Effects of Novel PPAR? Agonist, INT131, in an EcoHIV Mouse Model: Relevance to the Treatment of HIV-Associated Neurocognitive Disorders"
10:20 am - 10:25 am
Discussion
10:25 am - 10:40 am
Ashok Cheemala (UConn Health, United States)
"Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Barriers of the CNS: An Academic and Industry Perspective
Discussion Leaders: Matthew Campbell (Trinity College Dublin, Ireland) and Dionna Williams (Emory University, United States)
1:30 pm - 2:30 pm
Panel Discussion
An Academic and Industry Perspective
Michelle Pizzo (Denali Therapeutics, United States)
Tae-Eun Park (Ulsan National Institute of Science and Technology (UNIST), South Korea)
Roberto Villasenor (Roche Innovation Center Basel, Switzerland)
Paul Lockman (West Virginia University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes