Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
The Complexity of Mammalian Complex I
Discussion Leader: Judy Hirst (University of Cambridge, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
James Blaza (MRC Mitochondrial Biology Unit, United Kingdom)
"Insights into the Structure and Mechanism of Mammalian Complex I"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Mike Ryan (Monash University, Australia)
"Assembly of Human Mitochondrial Complex I"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Ulrich Brandt (Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands)
"Assembly and Mechanism of Mitochondrial Complex I"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Respiratory Chain and Oxidative Stress
Discussion Leader: Susanne Arnold (Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, The Netherlands)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Artur Osyczka (Jagiellonian University, Poland)
"Intermediate Radical States of Cytochromes bc1/b6f and Their Relation to ROS Production"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Alberto Sanz Montero (Newcastle University, United Kingdom)
"Site Specific ROS Production in Health and Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Isha Jain (Massachusetts General Hospital, USA)
"Developing Hypoxia as a Therapy for Mitochondrial Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Lothar Kussmaul (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
"Lowering Oxidative Stress by Targeting the Flavin Site of Complex I: A Drug Discovery Approach"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structures and Functions of
Supercomplex Assemblies
Discussion Leader: Carola Hunte (Institute for Biochemistry and Molecular Biology, BIOSS, University of Freiburg, Germany)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Karen Davies (Lawrence Berkeley National Laboratory, USA)
"Diversity of Mitochondrial Bioenergetic Complexes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Cristina Ugalde (Instituto de Investigacion Hospital 12 de Octubre (i+12), Spain)
"Structural Interdependences Among Respiratory Chain Complexes and Respirasome Formation"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Peter Brzezinski (Stockholm University, Sweden)
"Functional Interactions Within the Respiratory Chain"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Attacking the Bioenergetic Enzymes in Pathogens
Discussion Leader: Anthony Moore (University of Sussex, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Kiyoshi Kita (Nagasaki University, Japan)
"Parasite Mitochondrial Respiratory Chains as a Drug Target: Complex II, III and the Alternative Oxidase"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Dirk Bald (VU University Amsterdam, The Netherlands)
"Targeting Oxidative Phosphorylation with Next-Generation Antibiotics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Akhil Vaidya (Drexel University College of Medicine, USA)
"Mitochondrial Targets in Parasites for Malaria Treatment"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Gregory Cook (University of Otago, New Zealand)
"Advancing Bacterial Type-II NADH:Quinone Oxidoreductases as a New Target Space for Drug Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioenergetics on the Single Molecule Level
Discussion Leader: Robert Gennis (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Lars Jeuken (University of Leeds, United Kingdom)
"Single-Enzyme Studies of the Heme-Copper Oxidase, Cytochrome bo3, from Escherichia coli "
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Wayne Frasch (Arizona State University, USA)
"Elastic Energy Rotation Mechanism of the F1-ATPase"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hiroyuki Noji (The University of Tokyo, Japan)
"Single-Molecule Analysis of Bovine Mitochondrial ATPase"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Determining the Structures and Mechanisms of Complex Proton-Pumping Redox Enzymes
Discussion Leader: Thorsten Friedrich (University of Freiburg, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Peter Rich (University College London, United Kingdom)
"Insights into Cytochrome c Oxidase Mechanism from Studies of Yeast Mitochondrial CcO"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Leonid Sazanov (Institute of Science and Technology Austria, Austria)
"Structure and Mechanism of Complex I: From Bacterial to Mammalian Systems"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Ville Kaila (Technical University of Munich (TUM), Germany)
"Understanding the Mechanism of Long-Range Proton-Coupled Electron Transfer in Respiratory Complex I"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Maxie Roessler (Queen Mary University of London, United Kingdom)
"EPR Spectroscopic Investigations of Cluster N2 and Its Role in the Energy Coupling Mechanism of Complex I"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Masatoshi Murai (Kyoto University, Japan)
"Characterization of the Ubiquinone Binding Pocket of Respiratory Complex I Through Specific Chemical Modifications"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Itay Budin (University of California, Berkeley, USA)
"Physical Regulation of Bacterial Respiration by Membrane Lipid Composition"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics / Young Investigator Presentations
Discussion Leader: Wayne Frasch (Arizona State University, USA)
7:30 pm - 7:45 pm
Selected from Poster Abstracts: Valentina Giorgio (University of Padova, Italy)
"Calcium Binding to F-ATP Synthase Beta Subunit Triggers the Mitochondrial Permeability Transition"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Selected from Poster Abstracts: Ivan Lopez-Montero (Complutense University of Madrid, Spain)
"Mechanical Interaction of F1F0-ATPase with Lipid Membranes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Selected from Poster Abstracts: Ubaldo Martinez-Outschoorn (Thomas Jefferson University, USA)
"Multi-Compartment Metabolism in Human Carcinomas"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Selected from Poster Abstracts: Edward Owusu-Ansah (Columbia University Medical Center, USA)
"Regulation of Mitochondrial Complex I Biogenesis in Drosophila Skeletal Muscles"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Alastair Stewart (The Victor Chang Cardiac Research Institute, Australia)
"Cryo-EM Studies of E. coli ATP Synthase"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Denis Titov (Massachusetts General Hospital, USA)
"A Genetically Encoded Tool for Manipulation of the NAD+/NADH Ratio in Living Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
F- and V-Type ATPases: Molecular Machines and Drug Targets
Discussion Leader: Karlett Parra (University of New Mexico, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
John Walker (MRC Mitochondrial Biology Unit, Medical Research Council, United Kingdom)
"Structure, Mechanism and Regulation of ATP Synthases"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
Thomas Meier (Imperial College London, United Kingdom)
"Structure of Rotary ATP Synthase and Its Role as New Drug Target Against Tuberculosis"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Michael Forgac (Tufts University School of Medicine, USA)
"Function of the V-ATPases in Nutrient Sensing and Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Alena Zikova (Biology Centre, Czech Academy of Sciences, Czech Republic)
"Role of FoF1 ATP Synthase and IF1 in Bioenergetic Adaptions Occurring Throughout the Life Cycle of the Human Parasite Trypanosoma "
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Jose Faraldo-Gomez (National Institutes of Health, USA)
"Mitochondrial ATP Synthase: The Good, the Bad and the Ugly"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Abhishek Singharoy (University of Illinois at Urbana-Champaign, USA)
"How Hexameric Protein-Protein Interfaces Harness Energy Within Molecular Motors: Chemomechanical Coupling in V-Type ATPases"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Electron Transport Chain as an Essential Component
of Cellular Metabolic Networks
Discussion Leader: David Nicholls (Buck Institute for Research on Aging, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Kivanc Birsoy (The Rockefeller University, USA)
"Systematic Approaches to Study Mitochondrial Dysfunction in Mammalian Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Christian Frezza (MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, United Kingdom)
"Metabolic Alterations in Fumarate Hydratase Deficient Cells"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Alexander Galkin (Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, USA)
"Reversible Dissociation of Flavin from Mitochondrial Complex I as a Key Event During Brain Ischemia"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure