Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
New Insights into Host Defense and Pathogenesis
Discussion Leader: Lee Quinton (University of Massachusetts Chan Medical School, United States)
7:40 pm - 8:10 pm
Jonathan Kagan (Harvard Medical School/Boston Children's Hospital, United States)
"Initiation and Regulation of Innate Immunity"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Victor Nizet (University of California, San Diego, United States)
"Biomimetic Nanotherapeutics and Nanovaccines for Bacterial Pneumonia and Sepsis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Paul Bollyky (Stanford University, United States)
"Circulating Bacteriophages and the Diagnosis of Bacterial Lung Infections"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Cells in Pneumonia
Discussion Leader: Catharine Bosio (Rocky Mountain Laboratories, United States)
9:00 am - 9:25 am
Thirumala-Devi Kanneganti (St. Jude Children's Research Hospital, United States)
"Molecular Mechanisms of Innate Immunity and Inflammation in Health and Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Katrin Mayer-Barber (National Institutes of Health, United States)
"The Inflammatory Lung Microenvironment at the Time of Exposure Governs Innate Resistance to SARS-CoV-2 in Mice"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Elise Armstrong (Boston University, United States)
"Lung Interstitial Macrophage Responses During and After Recovery from Pneumococcal Respiratory Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Hans-Uwe Simon (Institute of Pharmacology, University of Bern, Switzerland)
"The Role of Ion Channels in Neutrophil Extracellular Trap Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Aoife Rodgers (Airway Innate Immunity Research Group, Queen's University Belfast , United Kingdom)
"Elucidating the Role of Streptococcus Pneumoniae Capsule in Innate Immune Responses in Macrophage"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Monica C. Gestal (LSU Health Science Center at Shreveport, United States)
"The Hidden Role of Eosinophils During Bordetella Spp. Infections"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Stephen Gurczynski (University of Michigan, United States)
"Role of Tryptophan Metabolites and AHR Signaling in Coronavirus Exacerbations of Pulmonary Fibrosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Xiaoqin Wei (University of Virginia, United States)
"Macrophage Peroxisomes Guide Proper Alveolar Repair and Prevent Post Acute Sequelae of COVID-19"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Julie Ledford (University of Arizona, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bacterial Virulence in the Lung
Discussion Leader: Carlos Orihuela (The University of Alabama at Birmingham, United States)
7:30 pm - 7:55 pm
Daniel Voth (University of Arkansas for Medical Sciences, United States)
"Everybody Relax: Coxiella Subversion of Human Macrophage Stress Signaling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Nicholas Carbonetti (University of Maryland School of Medicine, United States)
"Age-Related Effects of Interferons on Outcomes of Bordetella Pertussis Infection"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
W. Edward Swords (University of Alabama at Birmingham, United States)
"Determinants of Haemophilus Influenzae Colonization and Host Inflammatory Exacerbation in COPD Related Infection"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kristin Hudock (University of Cincinnati and Cincinnati Children’s Hospital, United States)
"Neutrophil Extracellular Traps Promote Pseudomonal Infection of Human Bronchial Epithelia"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Signaling Networks in Pneumonia
Discussion Leader: Sunny Shin (University of Pennsylvania Perelman School of Medicine, United States)
9:00 am - 9:25 am
Xiaoyang Hua (University of Iowa Hospitals and Clinics, United States)
"Nasal-Restricted Viral Infection Remotely Exacerbates Asthma Through B-Cell Dependent Recruitment of Inflammatory Monocytes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Cecilia Johansson (Imperial College London, United Kingdom)
"Lung Inflammation and Disease Severity During RSV Infection"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Lokesh Sharma (University of Pittsburgh Medical Center , United States)
"TLR9 in Host Defense Against Influenza Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Colin Reardon (University of California, Davis, United States)
"Neuroimmune Control of Acute Lung Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Benjamin Wu (New York University Langone Health Center / Veteran Affairs NY Harbor Healthcare System, United States)
"Multiple Oral Commensal Aspiration Induces Resistance to Lower Airway Pneumococcus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Sarah Clark (University of Colorado School of Medicine, United States)
"The Species-Specific Impact of Airway Prevotella on Lung Infection Resilience"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yewoo Lee (Boston University Chobanian and Avedisian School of Medicine, United States)
"Single-Cell RNA Sequencing Analysis of Oncostatin M-Oncostatin M Receptor Signaling in the Lungs"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Michael Vannini (Boston University School of Medicine , United States)
"Cell-Specific CD40 Expression During Development of Lung-Resident Heterotypic Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Viral Pathogenesis in Pneumonia
Discussion Leader: Ilona Jaspers (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:55 pm
Scott Biering (University of California, San Diego, United States)
"Virus-Triggered Barrier Dysfunction: Mechanism, Impact, and Intervention"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Stephania Cormier (Louisiana State University, United States)
"The Missing Shield: How RSV Severity Stems from Inadequate IgA Defenses in the Respiratory Mucosa of Infants"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Lisa Gralinski (University of North Carolina at Chapel Hill, United States)
"SARS-CoV-2 Pathogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Lea Denker (University of Warwick, United Kingdom)
"Altering Cellular Architecture: The Role of Coronavirus Non-Structural Proteins 3 and 4 in Membrane Deformation and DMV Formation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural Cells, Lung Matrix and Other Mediators in Pneumonia Outcomes
Discussion Leader: Andrew Vaughan (University of Pennsylvania, United States)
9:00 am - 9:25 am
Wellington Cardoso (Columbia Center for Human Development, Columbia University Medical Center, United States)
"Impact of Tnr6a and Local Translation in Airway Epithelial Differentiation and Innate Immunity Development"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Rachel Scheraga (Cleveland Clinic, United States)
"TRPV4 Protects the Lung from Injury After Bacterial Pneumonia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Anna Scasny (University of Mississippi Medical Center, United States)
"Oxidation of Hemoproteins by Streptococcus Pneumoniae Collapses the Cell Cytoskeleton and Disrupts Mitochondrial Respiration Leading to Cytotoxicity of Human Lung Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Nicholas Arpaia (Columbia University Irving Medical Center, United States)
"Regulation of the Alveolar Regenerative Niche by Treg Cells in Acute Respiratory Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Julie Ledford (University of Arizona, United States)
"CC16 and Epithelial Driven Host Responses During Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Alice Prince (Columbia University, United States)
"Airway Fibroblasts Fuel S. Aureus Infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Erin Earnhardt (University of Alabama-Birmingham, United States)
"Influenza A Virus Induced Endoplasmic Reticulum Stress Confers Susceptibility to Streptococcus Pneumoniae"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ashley Wilkins (LSU Health Shreveport, United States)
"Deciphering the Role of Host Lipids in Legionella Pneumophila Intracellular Replication"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unusual Infections and Co-Infections in the Pneumonia Outcomes
Discussion Leader: Dane Parker (Rutgers New Jersey Medical School, United States)
7:30 pm - 7:55 pm
DeBroski Herbert (University of Pennsylvania, United States)
"Regulation of Helminth Immunity in the Lung"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Gregor Gorkiewicz (Medical University of Graz, Austria)
"The Intricate Relationship Between SARS-CoV-2, DAD and the Development of Secondary Infections"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Eric Schmidt (Massachusetts General Hospital, United States)
"The Impact of Influenza-Induced Glycocalyx Shedding on Secondary MRSA Pneumonia"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Alison Kell (University of New Mexico, United States)
"Innate Immunity in Reservoir Infections with Pathogenic Hantaviruses"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Age, Sex and Other Factors in Pneumonia Outcomes
Discussion Leader: Luisa Morales-Nebreda (Northwestern University, United States)
9:00 am - 9:25 am
William Zacharias (Cincinnati Children's Hospital, United States)
"Inflammatory Injury and Anti-Inflammatory Therapeutics in Third Trimester Primate Lung Development"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Durga Singer (University of Michigan, United States)
"The Influence of Sex and Obesity on Pulmonary and Extrapulmonary Myeloid Responses"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Devin Kenney (NEIDL / Boston University Chobanian and Avedisian School of Medicine, United States)
"Sex Shapes Lung Antiviral Immunity Upon Heterologous Viral Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Alison Carey (Drexel University College of Medicine, United States)
"Age-Specific Differences in the Innate Immune Response During Infant Respiratory Viral Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Monica Valtierra-Alvarado (Rocky Mountain Laboratories, NIAID/ NIH, United States)
"Lung Intrinsic Resistance to Bacterial Infection in Obese Mice"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Clemente Britto (Yale University, United States)
"Sex-and Pathogen-Specific Airway Neutrophil Signaling in Cystic Fibrosis Airways"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kartik Rajagopalan (UT Southwestern Medical Center, United States)
"Leptin's Role in the Response to Influenza Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurologic Signals and Circadian Rhythms in Pneumonia Control
Discussion Leader: Jacqueline Kimmey (University of California, Santa Cruz, United States)
7:30 pm - 7:40 pm
Fengli Zhu (The Lundquist Institution for Biomedical Innovation at Habor UCLA, United States)
"Vasoactive Intestinal Peptide Regulates Immunoglobulin Release in Response to Streptococcus Pneumoniae Infection"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:10 pm
Emily Hemann (Ohio State University, United States)
"Type III IFN Sustains Adaptive Immune Responses to Limit Pulmonary Damage After Viral Infection"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Shaon Sengupta (University of Pennsylvania, United States)
"Circadian Rhythm and Pneumonia"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Isaac Chiu (Harvard Medical School, United States)
"Vagal Nociceptor Neurons Regulate Immune Responses and Respiratory Pathogen Infection Outcome"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure