Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Translational Chemical Biology
7:40 pm - 8:10 pm
"Glycans at the Host-Microbe Interface"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Targeting DOT1L Recruitment in MLL-Rearranged Leukemia"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Illuminating Protein Homeostasis and Preventing Pathogenesis with Bioactive Small Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Using Chemical Biology to Interrogate the Connection Between Altered Circadian Rhythms and Cancer"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Probes for Imaging
9:00 am - 9:30 am
"Probes for Dissecting In Vivo Pharmacology Using Confocal Microscopy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Light-Controlled Modulation of Gene Expression by Chemical Optoepigenetic Probes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Electrophysiology, Unplugged: Fluorescent Tools to Watch Cells in Action"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Strategy for Cell Selective Imaging Probe Development"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Multiplexed In Vivo Imaging with Shortwave Infrared Fluorophores"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Accelerating Drug Discovery Through the Power of Microscopy Images"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Automation, Big Data and Machine Learning in Drug Discovery
7:30 pm - 8:00 pm
"AI-Assisted Drug Discovery: What, How and Why?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Chemical Probes for Cancer Medicine: The Data and the Data Science"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Superficial Intelligence: Putting Machine Learning to Work in Drug Discovery"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Probes and Leads: Discovery and Triage
9:00 am - 9:30 am
"SLC Transporter Chemical Biology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Public Data for Chemical Biology: The Past, the Current and the Future"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Chemical Tools for Unraveling Parasite Biology"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Small-Molecule Interrogation of Proteostasis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Proteomic Profiling Illuminates Engagement of Higher Order CDKs for an Optimized CDK9 Inhibitor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Chemical Approaches to Unravel Mechanisms and Functions of Novel Histone Modifications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Probes and Leads: Optimization and Application
7:30 pm - 8:00 pm
"Attenuating Oncogenic Transcription with Small Molecules"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"High-Throughput Behavior Based Neuroactive Drug Discovery in the Zebrafish"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Chemical Biology Approach to Model a Rare Neurodegenerative Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Small-Molecule TEAD-Yap Covalent Antagonists"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Application of Omics to Decipher Biology
9:00 am - 9:30 am
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Activity Landscapes of Tumor Cell Lines Reveal Mechanisms of Drug Sensitivity and Resistance"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Using Funky Fragmentation to Build New Chemoproteomic Assays"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Activity-Based Sensing and Activity-Based Proteomics Approaches to Studying Metal and Redox Biology"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Identification of p300/CBP as the Cellular Target of the Small Molecule 'BRD16' Following a Phenotypic Screen"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Pathways and Platforms Spanning Space, Time and Reactivity in the Proteome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Synthetic Biology Approaches to Study and Control the Transcriptome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Looking for Drugs in Unconventional Places
7:30 pm - 8:00 pm
"Microbiome and Natural Products"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Deciphering the Human Microbiota Using Chemistry"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Mapping of Immunomodulatory Receptor Protein Interactions via Photoactivation-Based Proximity Labeling of the Cell Surface"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Technologies in Translation Chemical Biology
9:00 am - 9:30 am
"Chemical Probes of Intracellular Target Occupancy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Reimagining Druggability Using Chemoproteomic Platforms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Chemical Biology Tools for Target Identification and Validation"
11:05 am - 11:10 am
Discussion
11:10 am - 11:40 am
"IRAK4 Degradation with Orally Active Compounds in MYD88 Driven Diseases"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Applications of Clickable Chemical Biology in Drug Discovery"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Peptide-Based Tools to Interrogate Quorum Sensing Signaling in Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"RNA as a Drug Target and Material for Nanotechnology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Fluorogenic Probes for Visualizing Biology"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Chemical Probing of Coding and Non-Coding RNA Biology"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Chemical Tools that IMPACT Lipid Signaling"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure