Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Future of Biotherapeutics and Vaccines Development
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Pioneering Drug Discovery: Past, Present, and Future"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"High Resolution 3D Printing to Enable New Dosage Forms and Diagnostics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Vaccine Technologies in a Brave New World: Innovation, Access, Readiness, Impact"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Targeting EXosites and ACTive Sites on Coagulation Enzymes to Create Potent, Reversible and Sustainable EXACT Anticoagulants"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Synthetic Immune Receptor (SIR), a Next Generation Cell Therapy Platform"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"In Vivo mRNA-Based CAR T-Cell Therapy for the Treatment of B Cell-Mediated Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Gut Check: Living Yeast Biotherapeutics for Inflammatory Bowel Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Realizing the Promise of In Vivo CART Products"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Reimagining T Cell Therapy: An Unconventional Path to Universal CAR-T Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Approaches for Novel Target and Drug Discovery
7:30 pm - 7:50 pm
"Multi-Omics Profiling of Cancer-Associated Fibroblasts for Target Discovery"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Learning Cellular Biology through Optical and Transcriptional CRISPR Screening"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"From Human Genetics to Target Discovery for Cardiovascular Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Targeting Macrophages in Hypovascularized Metastatic Lesions in the Liver"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Therapeutic Protein Engineering and Optimization
9:00 am - 9:20 am
"Design and Engineering of Brain-Penetrating Biologics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Multiparameter Optimization of Therapeutic Biologics using AI and Other Methods"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Smart Biologics Driving the Next Wave of Biologic Therapeutics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Dual-Binding Antibody Regulation: A Novel Platform for Generation of Conditionally-Active Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Discovery and Engineering of IgE-Targeted Therapeutics for IgE-Mediated Allergic and Atopic Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Expanding the Reach of Biotherapeutics through Structure-Guided Design"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bench to Bedside: Academia, Pharma and Patients
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"From Academia to AI-Driven Biotech: Bridging Discovery and Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Broad Spectrum Influenza Protection by Mixtures of Subthreshold Dose Antigen Strain Variants"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Lessons from the Venture Side"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Biopharmaceutical Confectionary: Crafting Better Biologics with AI, Systems Biology, Protein and Cell Glycoengineering"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Post Approval Process Development: Science of Supply"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Process Development Strategies for Early- and Late-Stage Cell Therapies"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Adaptive Machine Learning Framework for Rapid Experimental Optimization of Viral Vector Purification Process"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Compounded Heterogeneity: The Complexity of Viral Vector Behavior During Dhromatography"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Talk Selected from GRS
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Analytics and Therapeutic Product Characterization
7:30 pm - 7:50 pm
"Escaping the Support Trap: How the QbD Paradigm Redefines the Value of Analytical Sciences"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"13 C Metabolic Flux Analysis in Cell Line and Bioprocess Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Approaches and Considerations for Bridging to New Analytical Methods"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Linking Molecular Mechanism to Clinical Immunogenicity and Efficacy in Vaccines"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Formulation, Drug Product and Delivery
9:00 am - 9:20 am
"From Candidate to Clinic: Designing Robust, Phase-Appropriate Drug Products for Early Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Opportunities to Elevate Novel Modalities and Maximize their Science"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Rapid In-vivo Endosomal Escape Assay Reveals Insights into Mechanism of Efficient Lipid Nanoparticle-based RNA Delivery"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Engineering Delivery Systems for Genetic Medicine and Vaccines"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Ionic Liquid-based Strategies for Biologics Delivery"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Directing Drug Delivery Systems in the Vasculature: Fortuitous Homing vs Cognizant Targeting"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Reverse Vaccinology-Inspired Development of Active and Passive Immunization Strategies Against CMV and RSV"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"RNA-based Vaccines Against Emerging Viral Infections"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Combatting Bacterial Infections with mRNA Vaccines"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Framework to Fast Track Multivalent Vaccine Development"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure