Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Progenitors in Bone Development and Repair |
| Discussion Leader: Henry Kronenberg (Massachusetts General Hospital, USA) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:10 pm | Christa Maes (KU Leuven, Belgium) "Mechanisms Regulating the Destination of Progenitor Cells in Bone Development and Repair" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Vicki Rosen (Harvard School of Dental Medicine, USA) "Mechanisms of Cortical Bone Growth" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Deneen Wellik (University of Michigan Health System, USA) "Hox Genes in Skeletal Development and Repair" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Bone Marrow Constituents and Skeletal Growth |
| Discussion Leader: Pamela Robey (National Institute of Dental and Craniofacial Research, CSDB, NIH, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany) "Molecular Coupling of Bone Angiogenesis and Osteogenesis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Laurie McCauley (University of Michigan, USA) "Macrophages: Big Eaters with a Big Role in Bone" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Selected from Poster Abstracts: Stavros Manolagas (University of Arkansas for Medical Sciences, USA) "The Quest of Estrogen Target Genes in Bone: A 2016 Update" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Thomas Clemens (Johns Hopkins University, USA) "Role of Sensory Nerves in Bone" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Clifford Rosen (Maine Medical Center Research Institute, USA) "Bone Marrow Adipocytes: Fat, Bone, or Other?" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Kenn Holmbeck (National Institute of Dental and Craniofacial Research, NIH, USA) "MT1-MMP-Mediated Proteolysis in Osteogenic Cells Is Essential for Retention of Multi Potent Bone Marrow Stromal Stem/Progenitors and Attenuation of Adipogenic Differentiation Through DLK1-Shedding" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Dynamics of Osteocytes and Osteoblasts |
| Discussion Leader: Lynda Bonewald (University of Missouri-Kansas City, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Sarah Dallas (University of Missouri-Kansas City, USA) "Cross Talk Between Osteocyte Cell Processes and Marrow" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Mitch Schaffler (City College of New York, USA) "Osteocyte Stimulus-Perception and Regulation of Bone Repair" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Marilina Piemontese (University of Arkansas for Medical Sciences, USA) "Glucocorticoid Action in Osteoblast-Lineage Cells Is Required for Attainment of Normal Bone Mass but Also for the Cortical Bone Loss Caused by Glucocorticoid Excess" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Nunzia Di Maggio (University of Basel, Switzerland) "Short-Term Delivery of VEGF Protein for Vascularized Engineered Bone" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regeneration of the Dentition |
| Discussion Leader: Ophir Klein (University of California, San Francisco, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Pascal Schneider (University of Lausanne, Switzerland) "Pharmacological Manipulation of the EDA-EDAR Pathway" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Samuel Stupp (Northwestern University, USA) "Bioactive Supramolecular Biomaterials for Bone and Enamel Regeneration" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Selected from Poster Abstracts: Bernhard Ganss (University of Toronto, Canada) "From Enamel Maturation to Dentogingival Attachment: Novel Proteins and Potential Therapeutic Targets" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jukka Jernvall (University of Helsinki, Finland) "Engineering Mouse Teeth" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Jeffrey Streelman (Georgia Institute of Technology, USA) "Plasticity of Epithelial Stem Cells in Tooth and Taste Bud Regeneration" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Masaki Honda (Aichi-Gakuin University School of Dentistry, Japan) "Human iPS Cells Are Capable of Differentiating into Ameloblasts, Odontoblasts, and Cementocytes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Osteoclasts in Bone and Joint Health and Disease |
| Discussion Leader: Vicki Rosen (Harvard School of Dental Medicine, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Xu Cao (Johns Hopkins University, USA) "Subchondral Bone and Osteoarthritis" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Yousef Abu-Amer (Washington University School of Medicine, USA) "Inflammatory Osteolysis in Bone and Joint Diseases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Kent Soee (Vejle Hospital / University of Southern Denmark, Denmark) "Pit- and Trench-Forming Osteoclasts: A Distinction that Matters" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Yi-Ping Li (University of Alabama at Birmingham, USA) "G Protein Alpha 13 Signaling to Inhibit Osteoclast Activation and Function" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Rare Musculoskeletal Diseases and Possible Therapies |
| Discussion Leader: Kevin Jones (University of Utah, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Brendan Lee (Baylor College of Medicine, USA) "Osteogenesis Imperfecta: Novel Treatment Targets and Options" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jacqueline Hecht (The University of Texas Health Science Center, USA) "Therapeutic Strategies for Pseudoachondroplasia" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Selected from Poster Abstracts: Tatiana Besschetnova (Harvard School of Dental Medicine, USA) "Mouse Model of GAPO Syndrome: ANTXR1-Dependent Maintenance of Balance Between Mesenchymal Stem Cell Renewal and Differentiation" |
10:30 am - 10:40 am | Discussion |
10:40 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Aris Economides (Regeneron Pharmaceuticals, Inc., USA) "Modeling FOP in the Mouse Reveals the Molecular Pathophysiology of the Disease and Provides New Paths to Therapy" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Selected from Poster Abstracts: Katherine Motyl (Maine Medical Center, USA) "Hyperprolactinemia-Induced Hypogonadism Does Not Explain Bone Loss from the Atypical Antipsychotic Risperidone" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected from Poster Abstracts: Marie Wehenkel (St. Jude Children's Research Hospital, USA) "Chondrocyte-Autonomous Dysregulation of Erk Signaling Leads to the Development of Chondromatosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Adult Stem Cells and Dental Repair |
| Discussion Leader: Yang Chai (University of Southern California, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Ophir Klein (University of California, San Francisco, USA) "Mechanoregulation of Tooth Stem Cells" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Frederic Michon (University of Helsinki, Finland) "Incisors and Cornea: Comparative Study of Stem Cells and Renewal Strategies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Amnon Sharir (University of California, San Francisco, USA) "Revisiting the Role of Mouse Incisor Stem Cells in Maintenance and Repair" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Emi Shimizu (New York University College of Dentistry, USA) "The Role of EphrinB1 in the Repair Process of Dentin" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular and Systemic Regulators of Bone Biology |
| Discussion Leader: Steven Teitelbaum (Washington University School of Medicine, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Fanxin Long (Washington University Medical School, USA) "Glucose Metabolism and Bone Formation" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Selected from Poster Abstracts: Mathieu Ferron (Institut de Recherches Cliniques de Montréal, Canada) "Novel Role of Vitamin K-Dependent Gamma-Carboxylation in Bone Remodeling" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Selected from Poster Abstracts: Jean-Marie Delaisse (University of Southern Denmark, Denmark) "The Bone Marrow Envelope: A Likely Provider of Osteoprogenitors During Remodeling of Adult Human Bone" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:10 am | Selected from Poster Abstracts: Veronique Lefebvre (Cleveland Clinic Lerner Research Institute, USA) "SOX-Mediated Control of Osteogenesis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Selected from Poster Abstracts: Ling Qin (University of Pennsylvania, USA) "The Critical Role of Mesenchymal Progenitors in Initiating the Secondary Ossification Center at the Epiphyseal Cartilage" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Steven Teitelbaum (Washington University School of Medicine, USA) "Roles of Asxl2 in Bone Homeostasis and Energy Metabolism" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: VEGF Biology in Bone Health and Disease |
| Discussion Leader: Eileen Shore (University of Pennsylvania School of Medicine, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:40 pm | Bjorn Olsen (Harvard School of Dental Medicine, USA) "VEGF Biology in Bone Health and Disease" |
8:40 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |