Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stem Cells, Extracellular Matrix and Signaling Pathways that Govern Skeletal Biology
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Combinatorial Signal Perception in the BMP Pathway"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Organs to Organoids: Development and Application in the Mammalian Kidney"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Multiple Hereditary Exostoses: From Genetics to Pharmacological Intervention"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
"FGFs Signal to Mesenchymal Progenitors to Regulate Skeletal Patterning"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Making Faces: Variation of Forms in Evolution and Disease"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"One Flew over the Notch's Nest: Tooth Shape Variations and Enamel Defects"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"CXXC Finger Protein 1 Is Required for BMP Signaling During the Initiation of Chondrogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"MMP14 Cleaves PTH1R, Regulating the Contribution of the Chondrocyte-Osteoblast Lineage Continuum to Bone"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identification of Regulatory Elements of Early Murine Tooth Bud Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Piezo2 Expressed in Proprioceptive Neurons Is Essential for Skeletal Integrity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Establishing Stem Cell Niches Within Bones and Teeth
7:30 pm - 8:00 pm
"Dissecting the Bone Marrow Stromal Cell Lineage"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Modular Control of Musculoskeletal Integration"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"SHH Regulates the Intervertebral Disc Niche for Its Growth and Regeneration"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"SOX9 Safeguards Growth Plate but Not Articular Chondrocytes from Osteoblastogenesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adult Skeleton Physiology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Crosstalk Between Muscle and Bone: Role of the Myokine Irisin"
9:40 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Updates on the Endocrine Functions of Bone"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Osteocyte-Driven Bone Remodeling: Crosstalk Between Mechanical and Hormonal Signals"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Regulation of Bone by the Microbiome"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Cellular and Biomaterial Toolbox for the Development of a 3D In Vitro Engineered Bone Fracture Callus"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Novel Molecular Mechanism for the Activation of a BMP Type I Receptor, ALK2, Proposed from Research on Fibrodysplasia Ossificans Progressiva"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Skeleton and Disease: Changes in Signals, Stem Cells and Niches
7:30 pm - 7:55 pm
"Hypoxia Regulation of Metastasis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Systemic Tumor-Bone Communication: Role of Dkk1"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Systemic Control of Breast Cancer by the Skeleton"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Stem Cell Niches in the Oral Cavity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Skeletal Compartment Communication
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
"Role of Sensory Nerves in Bone Development and Repair"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Communication Between the Osteogenic, Angiogenic and Hematopoietic Compartments of the Developing and Postnatal Skeleton"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Crosstalk Between Osteoblasts and the Hematopoietic Marrow"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Genetic and Mobilization-Based Alteration in Mesenchymal Cell Fate"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Rescue of Muscle Function by Osteocalcin in Sarcopenia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Thermogenic and B-Adrenergic Induction of Sclerostin Suppresses Adipose Tissue Browning"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Separate Regulatory Variants at GDF5-UQCC1 Underlie Developmental Dysplasia of the Hip and Knee Osteoarthritis Risk"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies in Skeletal Biology
7:30 pm - 8:00 pm
"Engineering Artificial BMP and BMP Receptor Variants to Explore the Mechanism of Signal Transduction"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Extracellular Signaling in the TGF-β Family"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"Spatially-Resolved Transcriptome-Scale Molecular Profiling by MERFISH Characterizes Sub-Cellular RNA Compartmentalization and RNA Velocity In Situ to Reveal Cell-Cycle Dependent Gene Expression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Single Cell Transcriptomic Comparison of Embryonic Limb Bud and ESC-Derived Skeletal and Joint Progenitors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:45 am
"Distinct Mechanisms Underlie Cortical Versus Cancellous Bone Aging"
9:45 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Inter-Individual Differences in Skeletal Aging"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Hdac3 in Skeletal Development and Aging"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Regulation of Bone Growth and Osteocyte Survival by FGF Signaling Pathways"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"SHP2 Is Required for the Osteogenic Differentiation of OCPs by Suppressing Their Adipogenic Potential"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"YAP1 and TAZ Negatively Control Bone Angiogenesis and Osteogenesis by Limiting Hypoxia-Inducible Factor Signaling in Endothelial Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single Cell Transcriptomics Identifies a Unique Adipocyte Population that Regulates Bone Marrow Environment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Repair and Regeneration of Bones and Teeth
7:30 pm - 8:00 pm
"The Death of Dogma and the Transformation of Chondrocytes to Osteoblasts: A New Model of Bone Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"The Orchestration of Bone Repair: The Role of Monocytes, Macrophages and Osteoclasts"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Genetic and Acquired Heterotopic Ossification Are Driven by a Self-Amplifying Positive Feedback Loop of Hedgehog Signaling"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"The Influence of Cellular Metabolism on Digit Regeneration"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure