Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Translating Cancer Genetics and Epigenetics to Therapy
7:40 pm - 8:10 pm
"The Role of Transcriptional Cyclin Dependent Kinases in Oncology"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Tet Enzymes in Malignancy"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Translating Cancer Genomics to Clinical Care"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Coding Genome and Cancer
9:00 am - 9:25 am
"Personal Regulome Navigation of Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Transcriptional Coactivator PGC-1α Provides a Conduit Between DNA-Associated and RNA-Associated Proteins"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"An Intronic Deletion Triggering a Mitotic Oncogene"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Long Noncoding RNA Associated with Aberrant LKB1 Signaling"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Large-Scale Mechanistic Analysis of Tumor Evolution in Livers of Five Rodents"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Cancer Epitranscriptome
6:00 pm - 6:25 pm
"RNA m6A Methylation in Human Cancer"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"The Role of RNA Modifications in Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"miRNAs in Viral Oncogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Transposable Elements in the Normal and Cancer Epigenome"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epigenetic and Genetic Mechanisms
9:00 am - 9:20 am
"Structure and Function of Mammalian SWI/SNF Complexes in Cancer"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Epigenetic Regulation of Repetitive Elements in Cancer"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Epigenetic Regulation of Carcinogen Susceptibility"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"DNA Methylation Canyons Guide Long-Range Chromosomal Interactions"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Flanking Sequence Preferences of the DNMT3A R882H AML Mutation Affect Cellular DNA Methylation Patterns"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel DNA Methylation in Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Reassessment of N6-Methyladenine in Mammalian DNA"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Histone and DNA Methylation Crosstalk in Developmental and Neoplastic Overgrowth"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Functional Studies of the Cancer Genome and Epigenome
6:00 pm - 6:25 pm
"Cohesin Complexes in Myeloid Malignancies"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Mapping the Genetic Landscape of Human Cells"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Functional Genomic Characterization of Epigenetic Dependencies in Myeloma"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Modifications of RNA: Their Function and Role in Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Genetics and Epigenetics of Lymphoma and Immuno-Oncology
9:00 am - 9:25 am
"Epigenetic Mechanisms of Lymphomagenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Structural and Functional Modifications of the 3D Organization of the Genome in Non-Hodgkin Lymphoma"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"An Early Myc-Dependent Transcriptional Program Underlies Enhanced Macromolecular Biosynthesis and Cell Growth During B-Cell Activation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"The Molecular Underpinnings for Enhancing Immune Checkpoint Therapy with Combinatorial Epigenetic Therapy"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Epigenetic Therapy and Endogenous Retroviruses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Decoding Differentiation States in Immune Cells and T Cell Dysfunction in Tumors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genome-Wide Studies of Epigenetics and Cancer
6:00 pm - 6:25 pm
"Identifying the Noncoding Genetic Drivers of Cancer from Epigenetics"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Epigenetic Fields Induced by Chronic Inflammation: Mechanism of Formation and Clinical Impact"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Targeting Polycomb Group Proteins in Prostate Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Single Cell Whole Genome Sequencing for Population Genetic Inference of Cancer Dynamics"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Computational Approaches and Genome-Wide Approaches to Cancer Genetics and Epigenetics
9:00 am - 9:25 am
"Systematic Identification of Synergistic Regulators as Targets for Combination Therapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
" Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers that May Predispose to Leukemia"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"CTCFL and Its Impact on Gene Regulation and Interplay with CTCF Function"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Fixing ChIP with Next-Generation Spike-in Controls"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Mutant p53 Controls Epigenetic Program Promoting Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"A Role for Nuclear PP2A in Transcriptional Regulation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Marrying Drug-Induction of Viral Mimicry, the Inflammasome and DNA Repair Defects in Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Mutation in the Core of Histone H2B Represents a New Class of Oncogenic Drivers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cancer and the 4D Nucleome
6:00 pm - 6:25 pm
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Decoding Genome-Scale Epigenetic Alterations in Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Exploring Complete Chromatin Architecture"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure