Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Genetics and Epigenetics Drivers of Tumor Evolution
7:40 pm - 8:10 pm
"Studying Transcriptional Regulation with Functional Genomics"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Mutational Signatures in Cancer: From Mechanism to Medicine"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Transposable Elements and Cancer Epigenome Evolution"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics of Tumor Microenvironment
9:00 am - 9:20 am
"Network-Level Epigenetic Alterations in Cancer Evolution"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"RNA Epigenetics in Prostate and Lung Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Uncoupling Tissue Plasticity Mechanisms in Regeneration and Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Out of the Comfort Zone: Rethinking Approaches to Breast Cancer Dormancy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Reprogramming Cancer Cells into Antigen Presenting Cells as a Personalized Immunotherapy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Simultaneous Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine Improves Early Detection of Colorectal Cancer"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"New Epigenetic Therapy Strategies for Reversing Cancer Specific DNA Methylation Abnormalities"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Chemical Biology Tools to Probe the Cancer Epigenome and Transcriptome"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Targeting Epigenetic Vulnerabilities by Synthetic Lethality"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Intercepting Cancer with Ascorbic Acid: An Epigenetic Drug"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Tumor Genetic and Epigenetic Reprogramming
9:00 am - 9:20 am
"Targeted Therapy Resistance in Advanced Prostate Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms of Epigenetic Regulation and Therapeutic Response in Hormone-Driven Cancers"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Measuring and Predicting Cancer Evolution"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanisms of Stress Adaptive Plasticity During Colorectal Cancer Progression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"SWI/SNF Complex Inhibition: A Vulnerability in Androgen Receptor-Negative Prostate Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Decoding Pan-Cancer Gene Regulatory Programs Underlying Metastasis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Spatial Cancer Genomics and Epigenomics
6:00 pm - 6:20 pm
"Biology and Therapeutic Targeting of Cohesion-Mutant Myeloid Malignancies"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Longitudinal Analyses of Chromatin Heterogeneity in Tumor Initiation and Response to Therapy"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Spatial Multi-Omics Sequencing for Mapping Human Cancer Spatiotemporal Dynamics"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Tumor Heterogeneity Through the Lens of Spatial Omics and Self-Supervised AI"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Plasticity and Heterogeneity in Cancer
9:00 am - 9:20 am
"Decoding Epigenetic Heterogeneity in Tumor and Blood for Cancer Research, Diagnosis and Monitoring"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenomic Mechanisms of Breast Cancer Evolution"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Unraveling the Drivers of Cancer Plasticity Through Functional Genetics"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Thinking Outside the Chromosome: Interrogating Epigenetic Mechanisms in Noncanonicalchromatin Species"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Epigenetic Plasticity Drives an Invasive Progenitor State in Glioblastoma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Epiregulon: Inference of Single-Cell Transcription Factor Activity to Predict Drug Response and Drivers of Cell State"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Clonal Memory of Colitis Accumulates and Promotes Tumor Growth"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering the Role of Cis-regulatory Elements and Retrotransposons in Hepatocellular Carcinoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genetics and Epigenetics of Non-Coding Cancer Drivers
6:00 pm - 6:20 pm
"Epigenetic Dysregulation of Transposable Elements in Cancer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"RNA Methylation Suppresses Aberrant Mammary Differentiation and Neoplastic Transformation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Targeting METTL3 Induces Viral Mimicry Responses in a Subset of Colorectal Cancer Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Location, Location, Location: Charting Causes and Consequences of Tissue Selective Epigenetic Programs in Hormone-Driven Cancers"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Estrogen Receptor Driven Epitranscriptomics in Breast Cancer Brain Metastasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Chromatin Regulation by RNA Methylation in Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Targeting RNA Modifications in Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Differential rRNA m5C Methylation Orchestrates Ribosome Specialization to Fine-Tune Translation and Genome Decoding During the Cell Cycle and in Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"RNA Modifications in Health and Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel Long Non-Coding RNA Interactions with EZH2 Coordinate Drug Resistance in Multiple Myeloma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Androgen Stimulation Rapidly Reorganizes Temporal 3D Genome and Epigenome States to Trigger AR-Mediated Transcription in Prostate Cancer"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Tissue-Selective Enhancer Activity of ERα in Breast and Endometrial Cancer"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Co-Detection of Genetic and Epigenetic Information from Bisulfite Sequencing Using Validated Open-Source Bioinformatics Tools"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genomics and Epigenomics Technologies
6:00 pm - 6:20 pm
"Unlocking Cancer Immunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Decoding Transcriptional Bursting and Direct Transcriptional Responses to Perturbations"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Unveiling Epigenetic Regulation in Immune Cells: Single-Cell Multiomic Profiling of Histone Modifications in Human PBMCs"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Mapping Chromatin Accessibility in the Tumor Microenvironment with Spatial ATAC-seq"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Basal-Squamous Identity Mechanisms in Pancreatic Ductal Adenocarcinoma"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure