| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Perspectives on Cell Death and Survival |
| Discussion Leader: Henning Walczak (UCL Cancer Institute, United Kingdom) |
| 7:40 pm - 7:45 pm | Introduction by Discussion Leader |
| 7:45 pm - 8:20 pm | Eric Baehrecke (University of Massachusetts Medical School, USA)
"Autophagy, Cell Health and Cell Death" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:40 pm | Introduction by Discussion Leader |
| 8:40 pm - 9:15 pm | Douglas Green (St. Jude Children's Research Hospital, USA)
"Death and Undeath: To the Edge of Necroptosis
and Back" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Signalling,
Survival and Death |
| Discussion Leader: Marion MacFarlane (Medical Research Council Toxicology Unit, United Kingdom) |
| 9:00 am - 9:15 am | Vishva Dixit (Genentech, Inc., USA)
"Cell Death in Inflammation" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Hamsa Puthalakath (La Trobe University, Australia)
"Identification of a Novel Death Receptor (FUMR) Responsible for Immune Cell Death During Sepsis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Seamus Martin (Trinity College Dublin, Ireland)
"Exploring the Interface Between Cell Death and Inflammation" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Pascal Meier (The Institute of Cancer Research, United Kingdom)
"Ubiquitin-Dependent Regulation of TNF-Induced Cell Death" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Sebastian Kupka (University College London, United Kingdom)
"LUBAC and LUBAC-Associated Proteins in Cell Death and Inflammation" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Hao Wu (Harvard Medical School / Boston Children's Hospital, USA)
"Molecular Elucidation of Inflammasome Activation and Regulation" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Astrid Fauster (CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria)
"A Combined Chemical, Proteomic and Genetic Approach Identifies Novel Inhibitors and Targets for TNF-Induced Necroptosis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Matous Hrdinka (University of Oxford, United Kingdom)
"RIPK2 Active Conformation, but Not Its Kinase Activity, Is Essential for Pro-Inflammatory Signalling" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Domagoj Vucic (Genentech, Inc., USA)
"Regulation of Inflammatory and Cell Death Signaling by RIP Kinases" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Mitochondria and
Cell Death in Cancer |
| Discussion Leader: Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia) |
| 6:00 pm - 6:15 pm | Joseph Opferman (St. Jude Children's Research Hospital, USA)
"Revealing MCL-1's Role(s) During Differentiation" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Andrew Gilmore (Wellcome Trust Centre for Cell/Matrix Research, United Kingdom)
"Differential Binding Between BH3-Only and Anti-Apoptotic Bcl-2 Proteins Monitored by Protein Dynamics in Live Imaging Shows Single Cell Heterogeneity in Apoptotic Priming" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Selected from Poster Abstracts: Kelvin Cain (MRC Toxicology Unit, United Kingdom)
"Bioenergetic Reprogramming Induces Profound Changes in the Mitochondrial Proteome, 3D Mitochondrial Structure and Proteins that Regulate Death" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Grant Dewson (Walter and Eliza Hall Institute of Medical Research, Australia)
"VDAC2 Is a Critical Promoter of Bax Apoptotic Function" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Ana Garcia-Saez (University of Tübingen, Germany)
"Bax Pores, One Particle at a Time" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Selected from Poster Abstracts: Evripidis Gavathiotis (Albert Einstein College of Medicine, USA)
"Structural and Functional Insights into the Regulation of Bax Activation" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Mitochondria and
Cell Death in Neurodegeneration and Autoimmunity |
| Discussion Leader: Douglas Green (St. Jude Children's Research Hospital, USA) |
| 9:00 am - 9:15 am | Danielle Sliter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Mitochondria, Autophagy and Ubiquitin Phosphorylation" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Frank Edlich (University of Freiburg, Germany)
"Parkin Promotes Proteasomal Degradation of Misregulated Bax" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | J. Marie Hardwick (Johns Hopkins University, USA)
"Alternate Functions of BCL-xL and BAX" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Selected from Poster Abstracts: Solange Desagher (CNRS, France)
"Characterization of a Novel Pathway Regulating α-Synuclein Expression and Neuronal Death in Parkinson's Disease" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Lian Li (Emory University School of Medicine, USA)
"PINK1-Mediated Mitochondrial Signaling Against Neurodegeneration" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Atan Gross (Weizmann Institute of Science, Israel)
"Mitochondria Metabolism at the Crossroads of Life and Death" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Stephen Tait (Beatson Institute, Cancer Research UK, United Kingdom)
"Targeting Cancer by Inhibiting Apoptosis" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Juan Sanchez (Imperial College London, United Kingdom)
"Mitochondrial Dynamics Regulate the Apoptotic Threshold During the Onset of Embryonic Differentiation" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Nika Danial (Harvard Medical School, USA)
"Metabolic Control of Beta-Cell Survival" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Cell Death
Networks and Clearance |
| Discussion Leader: John Abrams (University of Texas Southwestern Medical Center, USA) |
| 6:00 pm - 6:15 pm | Shigekazu Nagata (Osaka University, Japan)
"Molecular Mechanism of Apoptotic Phosphatidylserine Exposure" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Barbara Conradt (Ludwig Maximilians University of Munich, Germany)
"How Do C. elegans Engulfment Pathways Promote Apoptosis?" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Inna Lavrik (Otto-von-Guericke University Magdeburg, Germany)
"Molecular Crosstalk of CD95 and TNFR1 Signaling Networks" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Guy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Proteolytic Cross-Talk in Cell Death Networks" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Will Wood (University of Bristol, United Kingdom)
"Detecting Death and Damage in Drosophila" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Selected from Poster Abstracts: Francesco Dazzi (King's College London, United Kingdom)
"Mesenchymal Stromal Cell Apoptosis in Graft-Versus-Host Disease" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Survival
and Death in Cancer |
| Discussion Leader: Atan Gross (Weizmann Institute of Science, Israel) |
| 9:00 am - 9:15 am | Marcus Peter (Northwestern University, USA)
"Killing Cancer Cells by DICE" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Dagmar Kulms (Experimental Dermatology, Germany)
"Caspase-8 Promotes Uncontrolled Progression of Cancer Cells" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Selected from Poster Abstracts: Gemma Kelly (Walter and Eliza Hall Institute of Medical Research, Australia)
"Investigating the Impact of TP53 Mutations/Loss on the Potential of MCL-1 Targeting for MYC-Driven Lymphoma Therapy" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Selected from Poster Abstracts: Mads Daugaard (University of British Columbia, Canada)
"Glycosaminoglycans as Novel Cancer Targets" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Gerry Melino (Medical Research Council, United Kingdom)
"The E3 Ubiquitin Ligase WWP1 Sustains the Growth of Acute Myeloid Leukemia" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Andreas Villunger (Medical University of Innsbruck, Austria)
"Caspase-2, Enigma No More" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Delphine Merino (Walter and Eliza Hall Institute of Medical Research, Australia)
"Breast Cancer and Metastasis: New Insights into Cell Death Pathways" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Selected from Poster Abstracts: Kirill Rosen (Dalhousie University, Canada)
"ErbB2 as a Regulator of Cancer Cell Survival" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Selected from Poster Abstracts: Julian Pardo (University of Zaragoza, Spain)
"The Dual Role of Inflammatory and Apoptotic Granzymes During Colorectal Carcinoma Development" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Non-Canonical
Death Pathways and Model Organisms |
| Discussion Leader: Eric Baehrecke (University of Massachusetts Medical School, USA) |
| 6:00 pm - 6:15 pm | Christine Watson (University of Cambridge, United Kingdom)
"Non-Apoptotic Cell Death in Mammary Epithelial Cells" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Michelle Riegman (Memorial Sloan Kettering Cancer Center, USA)
"Ferroptotic Cell Death Has Non-Cell-Autonomous Properties" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | John Abrams (University of Texas Southwestern Medical Center, USA)
"Death and 'Transposopathy'" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Rebekah Kells (University of Edinburgh, United Kingdom)
"Environmental Stress-Related 'Stem-Ness' in Aggressive B Cell Lymphoma" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Sharad Kumar (University of South Australia, Australia)
"Regulation of Autophagy-Dependent Midgut Degradation in Drosophila" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Scott Lowe (Memorial Sloan Kettering Cancer Center, USA)
"Tumor Suppressor and Tumor Maintenance Genes" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Programmed
Necrosis and Inflammation |
| Discussion Leader: Guy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA) |
| 9:00 am - 9:15 am | Kim Newton (Genentech, Inc., USA)
"Exploring the Pro-Survival Function of RIPK1" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Selected from Poster Abstracts: Ben Croker (Boston Children's Hospital, USA)
"Effector Functions of Necroptosis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Peter Vandenabeele (VIB, University of Ghent, Belgium)
"Role of RIPK3 in Cell Death and Inflammation" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Junying Yuan (Harvard Medical School, USA)
"The Role of RIPK1 in Necroptosis and Inflammation" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Selected from Poster Abstracts: Andrew Oberst (University of Washington, USA)
"RIPK3 Coordinates Neuroinflammatory Defense Against Viral Infection Independent of Necroptosis" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 11:10 am | Coffee Break |
| 11:10 am - 11:25 am | Francis Chan (University of Massachusetts Medical School, USA)
"Targeted Strike: Compartmentalized Function of RIPK3 in Inflammation" |
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Selected from Poster Abstracts: Diego Rodriguez (St. Jude Children's Research Hospital, USA)
"Non-Canonical Activation of Necroptosis: MLKL-Dependent Cell Death in Absence of RIPK3" |
| 11:45 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Manolis Pasparakis (University of Cologne, Germany)
"RIPK1 in Cell Death and Inflammation" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | John Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Cell Death and Inflammation in the Skin" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Translating Cell Death Discoveries Towards the Clinic |
| Discussion Leader: J. Marie Hardwick (Johns Hopkins University, USA) |
| 6:00 pm - 6:15 pm | Kristopher Sarosiek (Harvard T.H. Chan School of Public Health, USA)
"Dynamic Regulation of Apoptosis in Healthy Tissues" |
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Selected from Poster Abstracts: Andreas Linkermann (University of Kiel, Germany)
"MLKL Mediates Necroptosis in Humans" |
| 6:35 pm - 6:40 pm | Discussion |
| 6:40 pm - 6:55 pm | Selected from Poster Abstracts: Maria Guicciardi (Mayo Clinic, USA)
"A Novel Murine Model of SMAC Mimetic-Induced Acute Sclerosing Cholangitis" |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:15 pm | Selected from Poster Abstracts: Loren Walensky (Dana-Farber Cancer Institute, USA)
"Translating Pro-Apoptotic Peptide Helices to the Clinic" |
| 7:15 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:35 pm | Sandra Zinkel (Vanderbilt University School of Medicine, USA)
"Regulation of Cell Death Decisions in Hematopoietic Differentiation and Stem Cell Function" |
| 7:35 pm - 7:40 pm | Discussion |
| 7:40 pm - 7:55 pm | Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"Life Without Intrinsic Apoptosis: Consequences of Embryonic Development in the Combined Absence of BAX, BAK and BOK" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
