1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Signaling Pathways and Cell Growth Regulation
Yagya Chadha (Helmholtz Zentrum Munich, Germany)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:25 pm
Renee Read (Emory University School of Medicine, United States) "Triple Threat: Multi-Modal Model Systems in Therapeutic Discovery for High-Grade Gliomas"
4:25 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Cell cycle and disease
Junzhe Zha (The University of Manchester, United Kingdom)
7:30 pm - 7:40 pm
Jake Friske (St. Jude Children's Research Hospital, United States) "Understanding and Identifying the Impact of Amplified Regulatory DNA Regions on Double Minute Chromatin Bodies in MYC-Amplified Medulloblastomas"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Tzeh Keong Foo (Rutgers Cancer Institute of New Jersey, United States) "The Paradox of Premature Checkpoint Recovery of BRCA/PALB2 Deficient Cells Following Ionizing Radiation-Induced DNA Damage"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Jun Li (Memorial Sloan Kettering Cancer Center, United States) "Cancer Cell Non-autonomous Tumor Progression from Chromosomal Instability"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Daniel Bronder (Memorial Sloan Kettering Cancer Center, United States) "Chromosomal Instability Mediates Anti-Tumor Immunity in Pancreatic Cancer"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
Ryan Mouery (UNC Chapel Hill, United States) "Proteomic Analysis Reveals a Plk1-Dependent G2/M Degradation Program"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Yumi Konagaya (Ida) (Weill Medical College/Cornell University - New York, NY, United States) "A State of Partial Rb-E2F Activation Safeguards Proliferation Commitment"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Charlotte Meyer-Gerards (Universtity Hospital Cologne, Germany) "Dissecting the Mechanism of the Mitotic Surveillance Pathway in Mouse Embryonic Stem Cells"
9:10 pm - 9:15 pm
9:15 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Molecular Control of Cell Growth
Emmie Pohjanen (KTH Royal Institute of Technology, Sweden)
9:00 am - 9:10 am
Sahezeel Awadia (University of Michigan, Ann Arbor, United States) "The Adapter Protein FADD Provides an Alternate Pathway for Entry into the Cell Cycle by Regulating APC/C-Cdh1 E3 Ubiquitin Ligase Activity"
9:10 am - 9:15 am
9:15 am - 9:25 am
Albert Agustinus (Weill Cornell Graduate School of Medical Sciences, United States) "Epigenetic Dysregulation from Chromosomal Transit in Micronuclei"
9:25 am - 9:30 am
9:30 am - 9:40 am
Evgeny Zatulovskiy (Stanford University, United States) "Increase in Cell Size Globally Remodels the Proteome and Promotes Senescence"
9:40 am - 9:45 am
9:45 am - 9:55 am
Yagya Chadha (Helmholtz Zentrum Munich, Germany) "Cell Size Control in a Changing Environment"
9:55 am - 10:00 am
10:00 am - 10:10 am
Hanjun Lee (Massachusetts General Hospital, United States) "RB Regulates Cohesin Distribution to Repress Insulator Activity, Resulting in E2F-Independent Transcriptional Regulation"
10:10 am - 10:15 am
10:15 am - 10:25 am
Brandon Mouery (University of North Carolina at Chapel Hill, United States) "APC/C Activity is Essential to Maintain Drug-Induced Cell Cycle Arrest"
10:25 am - 10:30 am
10:30 am - 10:40 am
Shuyuan Zhang (Stanford University, United States) "Unraveling the Regulatory Mechanism of Rb Protein Concentration Through the Cell Division Cycle"
10:40 am - 10:45 am
10:45 am - 10:55 am
Junzhe Zha (The University of Manchester, United Kingdom) "Cell Adhesion Molecules Regulate Cell Cycle Progression in Pancreatic Cancer"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Growth control in development
Loren Chang (National Center for Advancing Translational Sciences, United States)
1:30 pm - 1:40 pm
Katherine Ferrick (Stanford University, Weill Cornell Medical College, United States) "YAP-dependent Reprogramming of a Proliferative Cellular State"
1:40 pm - 1:45 pm
1:45 pm - 1:55 pm
Dalia Fleifel (University of North Carolina at Chapel Hill, United States) "Racing Against Time: C-Myc Overproduction Accelerates Origin Licensing in a Short G1 Phase"
1:55 pm - 2:00 pm
2:00 pm - 2:10 pm
Lucas Morales (Imperial College London, United Kingdom) "Wee1 is Necessary for Timely S-Phase Entry"
2:10 pm - 2:15 pm
2:15 pm - 2:25 pm
Debasish Paul (NCI, NIH, United States) "mTOR-mediated Transient APC/C Inactivation Ensures Proper Cell Cycle Entry"
2:25 pm - 2:30 pm
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)