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Cell Polarity Signaling

Gordon Research Conference

Polarity and Asymmetry in Tissue Architecture and Cell Fate

June 2 - 7, 2024

Chair

Vice Chairs

and

Southern New Hampshire University

2500 North River Road

Manchester, New Hampshire, United States

Venue and Travel Information

Conference Description

The Cell Polarity Signaling GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Many types of cells and tissues, such as migrating cells, epithelial tissues, and asymmetrically dividing stem cells, develop polarities that are critical for their function. Defects in cell polarization severely disrupt development and tissue homeostasis, and loss of polarity is a key step in the progression of cancer. The Cell Polarity Signaling GRC will bring diverse areas of research together related to cell polarity, aiming to facilitate organic interactions and cross fertilization of distinct research subareas. The topics will include cell polarization, migration, asymmetric cell division in the context of development, tissue homeostasis and disease.

Please have poster abstracts submitted by May 5th, 2024.

Related Meeting

This GRC will be held in conjunction with the "Cell Polarity Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Molecular and Cellular Mechanisms of Cell Polarity Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:40 pm	"Dissecting the Roles of Antagonistic Interactions Between Polarity Factors in the Apical-Basal Polarisation of Epithelial Cells"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Tracing the Source of Embryonic Polarity in the Early Oocyte: Regulation of Symmetry Breaking and Molecular Condensation by a Conserved Centrosome MTOC Machinery"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell Polarization and Cytoskeleton Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Linking the Centriole to the Nucleus in Spermiogenesis"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Cellular Rejuvenation During Meiosis"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"The Missing Link of Surface Mechanics: Protein Caging Triggers Symmetry Breaking"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Planar Cell Polarity and Mechanosensing in Convergent Extension"
11:15 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Cellular and Tissue Polarity is Controlled by a Conserved Wnt-Ror-Dvl Signalling Cascade in C. Elegans Muscles"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Long Range Mutual Facilitation Complements Local Inhibition to Globally Pattern Rac and Rho During Cell Migration"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Negative Feedback Regulation in Cortical Excitability Requires F-Actin Interaction and Self-Association of RGA-3/4"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tissue Polarity During Development and Homeostasis Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Intestinal Cartography: Epithelial Dynamics During Pattern Formation in the Developing Mammalian Intestine"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"Defining the Role of Dishevelled in Planar Cell Polarity Establishment in the Mammalian Embryonic Epidermis"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Imaging How the Preimplantation Embryo Forms"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Multiple Roles for Inhibitory G Proteins in the Polarization of Auditory and Balance Hair Cells"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell Migration and Motility Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"The Evolution and Diversity of Actin-Dependent Cell Migration"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"The Asymmetric Fusogenic Synapse"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Leaders Can’t Lead Without Followers: The Discovery of a Polarity Regulated Rac Activity Pathway in Follower Border Cells"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Cell Polarity and Fate Specification in Echinoderms"
11:15 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Directional Cell Migration: Unveiling the Mechanism of Durotaxis"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Receptor Corralling Establishes Front-Rear Polarity During Bleb-Based Migration Under Confinement"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Asymmetric Cell Division Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Kiss and Say Goodbye: Emerging Mechanisms of Stem Cell Control"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"Combinatorial Role of Signaling Factors in the Maintenance of Drosophila Germline Stem Cell Fate"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"A Pathways for Asymmetric Chromosome Segregation in Response to Stress and Ageing"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Selfish Meiotic Drive Elements Exploit Asymmetry in Female Meiosis"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanisms of Asymmetric Division Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Deciphering Chromosome Segregation in Mammalian Eggs"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Deciphering Asymmetric Cell Fate Determination in C. Elegans Neuroblast Division"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Regulation of Cell Polarity Orientation by Expression Gradients of Wnt Receptors"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Asymmetric Cell Division during Hematopoiesis: Insights from Drosophila"
11:15 am - 11:25 am	Discussion
11:25 am - 11:35 am	"State Transitions and Lineage Specification in the Mouse Embryonic Midline"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"The Replicative Helicase CMG is Required for Cell Fate Divergence in C. Elegans"
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cell Polarity During Development Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Polarized Cell Interactions During Organ Formation in the C. Elegans Embryo"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"Polarized Contractility Drives Molecular Translocation to Promote Lumen Initiation and Growth"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Dynamics of Germline Cyst Formation in Mice"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Collective Induction of Oogenesis via Cytoplasmic Streaming in C. Elegans"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Tissue Polarization Planar Cell Polarity Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Think Globally, Act Locally: Control of Axon Guidance by Planar Polarity Cues"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Distinct Modes of PCP-Mediated Cell Intercalation in C. Elegans"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Crawling Under Your Skin: Understanding How Planar Cell Polarity Generates Polarized Cell Movements During Hair Follicle Morphogenesis"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Reversing the Axis of Epidermal Planar Polarity in the Rosette Fancy Mouse"
11:15 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Working Against the Clock: Leveraging the Biophysics of Polarization to Extend Reproductive Lifespan"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Mechanical Cues Organize Vertebrate Planar Cell Polarity Complexes and Collective Cell Behaviors During Embryonic Wound Repair"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Left-Right Asymmetry in the Positioning of Cell Organelles in Single Myoblasts"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Investigating Cell Polarity and Organelle Segregation in Singled-cell Divergent Eukaryotes using Expansion Microscopy"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cues for Cell Polarization and Fate Decisions Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Cytoskeletal Organization Controls Polarity During Patterning of the Leaf Surface"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:20 pm	"Spatio-Temporal and Molecular Evolution of the Apical Cell Cortex during Epithelial Polarity Development"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Fat Cadherin Control of Planar Cell Polarity"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"Epithelial Polarization via Myosin-Dependent Cortical Flow"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD115279. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Cell Polarity Signaling (GRS)

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