Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Science and New Horizons
in Mechanistic Toxicology
7:40 pm - 8:10 pm
"Toxicogenomics in the Era of Precision Medicine"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Daddy Issues: Paternal Effects of Diet and Toxins on the Next Generation"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Xenobiotic
Receptors and Their Novel Functions
9:00 am - 9:30 am
"Ah Receptor Is a Therapeutic Target for Drug-Induced Enteropathy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"CAR Scaffolds GADD45B to Regulate Cell Signaling in HCC Development"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Endobiotic Functions of Xenobiotic Receptors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary Carcinogenesis in Mice by Omega-3-Fatty Acids: Evidence for Mechanisms Entailing DNA Adducts as Well as Epigenetic Genes"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Molecular Mechanisms of Inter-Individual Variability in the Response to Toxic Exposures"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic
and Epigenetic Mechanisms of Toxicology
7:30 pm - 8:00 pm
"Chromatin Mechanisms of Epigenetic Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Epigenetic Mechanisms of Air Pollution-Induced Immune Dysfunction in Children"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Understanding the Role of Repetitive Elements in Toxicity Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Noncoding
RNA and Their Roles in Regulating Toxic Responses
9:00 am - 9:30 am
"piRNA Targeted DNA Methylation: Implication for Toxicological and Translational Sciences"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"RNA Methylation in Gene Expression Regulation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Non-Coding RNAs and Metal Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Plasma Viral and Cellular miRNAs as Targeted-Biomarkers of Occult Viral Infections Prevalence and Sepsis Aggressiveness"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"The Functions of lncRNA MALAT1 in Regulating Generation of Reactive Oxygen Species and the Insulin Responses in Mice"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Humanized Models: Where Are We Now?
7:30 pm - 8:00 pm
"Humanized Mouse Models – Success and Limitations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Cell Replacement Therapies – iPSC or Transdifferentiation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Translational In Vivo and In Vitro Models in Oncology Drug Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tick Tock Goes the Clock: Circadian
Rhythm of Gut Microbiota Influences Host Metabolic and Drug Functions
9:00 am - 9:30 am
"Epithelial Cell Contributions to Intestinal Immunity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
" Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Central Role of Circadian Rhythm in Cellular Responses to Toxicants and Stressors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Circadian Regulation of Polyaromatic Hydrocarbon Metabolism in Breast Cancer and Mouse Mammary Gland"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Bisphenol Compound Toxicity: Linking a Behavioral Phenotype to Microbiota Composition"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Non-Animal
Methods in Toxicology: Novel Mechanisms and New Opportunities
7:30 pm - 8:00 pm
"Systems Toxicology: Linking Network Perturbation to Phenotypes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Taxogenomic Read Across: Predicting Human Toxicity Using Non-Animal Species"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Where Is the Risk? In Vitro -In Vivo Extrapolations (IVIVE) Using Reverse Toxicokinetics"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
System Biological Approaches to Assessing
Xenobiotic Responses
9:00 am - 9:30 am
"An Integrative Data Mining Approach to Identify Adverse Outcome Pathway Signatures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Increasing Confidence in Read Across Through Big Science"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Evolution of Epigenetic Regulation in Vertebrate Genome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"US Tox21 Program: Using In Vitro qHTS Methods to Profile Environmental Chemicals"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Percellome Toxicogenomics Project for Mechanism-Based Toxicity Prediction"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Toxicity – A Path Forward
7:30 pm - 8:05 pm
"Genome-Wide CRISPR Library Screen Identifies a Transcriptional Repressor Complex that Suppresses Cellular ER Stress Response"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:55 pm
" Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure