Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Bridging the Gap Between Fundamental and Applied Peptide Science
7:40 pm - 8:20 pm
"Bridging the Gap Between Fundamental and Applied Science in DNA Recognition by Py-Im Polyamides"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Engineering New Peptide Ligases"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stabilized Peptide Therapeutics
9:00 am - 9:25 am
"Challenges and Emerging Approaches in Peptide Drug Discovery"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Orally Stable Peptides - Fact or Fiction? Or Discovery and Development of Orally Stable Peptides for Gastro-Intestinal (GI) Diseases"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Exploring the Signaling of D-Amino Acid-Containing Neuropeptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
" Mimicking Protein-Protein Interactions Through Peptide-Peptide Interactions: CXCR4 and HIV-1 gp120"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"The Optide Platform: Designing, Engineering, and Evolving Peptide Drug Candidates"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Peptide and Protein Synthesis
7:30 pm - 7:55 pm
"Automated Flow Peptide Synthesis: Toward Amide Bonds at Nature’s Pace"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Massively Parallel Synthesis and Screening of Linear Peptides and Macrocycles Using Peptide Microarrays"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Ligases: Specific Peptide Staplers"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
" Peptide Design and Assembly: From Fundamental Principles to Real-Life Applications"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
" Structure-Based Design of Broad Flavivirus Immunogens"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Shape-Specific Nanostructured Protein Mimics from De Novo Designed Chimeric Peptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Design and Synthesis of Highly Fluorinated Biopolymers as 19F MRI Contrast Agents"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Massively Parallel Investigation of De Novo Miniprotein Folding and Binding"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Amyloids and Peptide Self-Assembly
7:30 pm - 7:55 pm
"Conformational Polymorphisms of the Amyloid Aβ Peptide in Alzheimer’s Disease"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Understanding the Cellular Membrane Disruption Induced by Early-Stage Aggregation of Beta-Amyloid Peptides"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Chirality, Alzheimer's Disease and Amyloid Beta"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Engineering Armadillo Repeat Proteins as Modular Peptide Binders"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Exploring the Landscape of Bcl-2 Family Binding Peptides"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Accurate Computational Design of Heterochiral Constrained Peptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Engineering Complimentary Peptide and Antibody Attributes for Efficient Hybridization"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Molecular Basis of Protein-Carbohydrate Interactions"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Penetration and Drug Delivery
7:30 pm - 7:55 pm
" Exploring Macrocyclic Peptide Cell Permeability: Screening Tools and Design Rules"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
" Molecular Engineering of Helical Peptides: Designing Intracellular Therapeutics"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Peptide-Based Tools to Study Cell Signaling in Bacteria"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next-Generation Peptide Therapeutics
9:00 am - 9:15 am
"Stapled Peptide Inhibitors of the Estrogen Receptor/Coactivator Interaction"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Cell Penetration Profiling Using the Chloroalkane Penetration Assay"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Targeting Peptides for Nanomedicine"
10:05 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Rational Development of Bicyclic Peptides Targeting the Grb7 Cancer Target"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Reductionist Vaccine Design for HIV"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Plants as Biofactories for Producing Peptide-Based Pharmaceuticals"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Peptide-Based Materials for Regenerative Medicine Applications"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Peptide and Protein Nanomaterials: The Design Challenge"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Racemic Hydrogels from Mirror Image Peptides: Predictions from Pauling and Corey"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure