Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Chemokines: Insights from Structural and Functional Data
Discussion Leader: Tracy Handel (University of California, San Diego, USA)
3:45 pm - 3:55 pm
Nathan Reynders (Luxembourg Institute of Health, Luxembourg)
"Nanoluciferase Complementation-Based Assay to Monitor β-Arrestin Recruitment to Chemokine Receptors"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Natasha Moussouras (Medical College of Wisconsin, USA)
"Structural Studies into Autoinhibition by CCL21"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Max Meyrath (Luxembourg Institute of Health, Luxembourg)
"Atypical Ligand Binding and Activation Modes of ACKR3"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemokines in Homeostasis and Development
Discussion Leader: Susan Schwab (New York University School of Medicine, USA)
7:30 pm - 7:40 pm
Michael Wedemeyer (Medical College of Wisconsin, USA)
"Engineering an Orthogonal Chemokine:GPCR System Using Rosetta"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Olav Larsen (University of Copenhagen, Denmark)
"Binding and Activation Variation Within the CCR1-2-5 Axis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Stephanie Lau (New York University School of Medicine, USA)
"A Molecular 'Clamp' Regulates Sdf1a and Sdf1a-Guided Cell Migration"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Bianca Calì (University of Padova, Italy)
"CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Gwendolyn Patzer (Hannover Medical School, Germany)
"The Role of Heterotrimeric G Proteins in Homing and Migration of Lymph Derived T Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Yoshishige Miyabe (Massachusetts General Hospital, USA)
"Complement C5a Receptor Regulates CXCR2-Mediated Neutrophil Adhesion"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mieke De Buck (KU Leuven, Belgium)
"COOH-Terminal SAA1 Peptides Fail to Induce Chemokines but Synergize with CXCL8 and CCL3 to Recruit Leukocytes via FPR2"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kathrin Werth (Hannover Medical School, Germany)
"Homing of Activated, Lymph-Derived T Cells Involves a Mechanical 3D Sieve Barrier of the Subcapsular Sinus and Chemokine Receptors but Is Independent of Integrins and Selectins"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemokine Control of Immune Activation and Disease
Discussion Leaders: Andrew Luster (Massachusetts General Hospital, USA) and Antal Rot (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
9:00 am - 9:10 am
Jeffrey Lian (Harvard University, USA)
"Targeting Lymph Node Niches to Enhance Type 1 Immune Responses to Immunization"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Anna Barkaway (William Harvey Research Institute, United Kingdom)
"Age-Related Systemic Inflammation Supports Aberrant Neutrophil Transendothelial Migration"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ariadni Kouzeli (Cardiff University, United Kingdom)
"Identification of CXCL14-Responsive Cells in Healthy Peripheral Tissues"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Marieke Pingen (University of Glasgow, United Kingdom)
"The Role of Dendritic Cells in the Dissemination of Mosquito-Transmitted Alphaviruses"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Chie Miyabe (Massachusetts General Hospital, USA)
"Dectin-2-Induced CCL2 Production in Cardiac Macrophages Ignites Vascular Inflammation in a Murine Model of Kawasaki Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Carla Gibbs (Meharry Medical College, USA)
"CXCL14 Suppresses the Aggressive Phenotype in Triple Negative Breast Cancer (TNBC) Through CXCR4"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Anna Vilgelm (Vanderbilt University, USA)
"Drug-Induced Senescence Promotes Anti-Tumor Immunity via the Induction of CCL5"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Rod Rahimi (Massachusetts General Hospital / Harvard Medical School, USA)
"Aeroallergen-Induced Central Memory CD4+ T Cells Induce Allergic Airway Inflammation Independently of Lung-Resident Memory"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Pathways
Discussion Leaders: Caroline Sokol (Massachusetts General Hospital, USA) and Tamara Girbl (Queen Mary University of London, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Career Pathways
Reinhold Förster (Hannover Medical School, Germany)
Marcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
Maud Deruaz (Massachusetts General Hospital / Harvard Medical School, USA)
Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
