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Saturday
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| 2:00 pm - 5:00 pm |
Arrival and Check-in
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| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:45 pm - 4:30 pm |
Chemokines: Insights from Structural and Functional Data
Discussion Leader: Tracy Handel (University of California, San Diego, USA)
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| 3:45 pm - 3:55 pm |
Nathan Reynders (Luxembourg Institute of Health, Luxembourg)
"Nanoluciferase Complementation-Based Assay to Monitor β-Arrestin Recruitment to Chemokine Receptors"
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| 3:55 pm - 4:00 pm |
Discussion
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| 4:00 pm - 4:10 pm |
Natasha Moussouras (Medical College of Wisconsin, USA)
"Structural Studies into Autoinhibition by CCL21"
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| 4:10 pm - 4:15 pm |
Discussion
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| 4:15 pm - 4:25 pm |
Max Meyrath (Luxembourg Institute of Health, Luxembourg)
"Atypical Ligand Binding and Activation Modes of ACKR3"
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| 4:25 pm - 4:30 pm |
Discussion
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| 4:30 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
Chemokines in Homeostasis and Development
Discussion Leader: Susan Schwab (New York University School of Medicine, USA)
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| 7:30 pm - 7:40 pm |
Michael Wedemeyer (Medical College of Wisconsin, USA)
"Engineering an Orthogonal Chemokine:GPCR System Using Rosetta"
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| 7:40 pm - 7:45 pm |
Discussion
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| 7:45 pm - 7:55 pm |
Olav Larsen (University of Copenhagen, Denmark)
"Binding and Activation Variation Within the CCR1-2-5 Axis"
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| 7:55 pm - 8:00 pm |
Discussion
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| 8:00 pm - 8:10 pm |
Stephanie Lau (New York University School of Medicine, USA)
"A Molecular 'Clamp' Regulates Sdf1a and Sdf1a-Guided Cell Migration"
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| 8:10 pm - 8:15 pm |
Discussion
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| 8:15 pm - 8:25 pm |
Bianca Calì (University of Padova, Italy)
"CXCL12/SDF-1 Modulates the Rheological Properties of the Nucleus of Mouse Neutrophils"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:40 pm |
Gwendolyn Patzer (Hannover Medical School, Germany)
"The Role of Heterotrimeric G Proteins in Homing and Migration of Lymph Derived T Cells"
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| 8:40 pm - 8:45 pm |
Discussion
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| 8:45 pm - 8:55 pm |
Yoshishige Miyabe (Massachusetts General Hospital, USA)
"Complement C5a Receptor Regulates CXCR2-Mediated Neutrophil Adhesion"
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| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:10 pm |
Mieke De Buck (KU Leuven, Belgium)
"COOH-Terminal SAA1 Peptides Fail to Induce Chemokines but Synergize with CXCL8 and CCL3 to Recruit Leukocytes via FPR2"
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| 9:10 pm - 9:15 pm |
Discussion
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| 9:15 pm - 9:25 pm |
Kathrin Werth (Hannover Medical School, Germany)
"Homing of Activated, Lymph-Derived T Cells Involves a Mechanical 3D Sieve Barrier of the Subcapsular Sinus and Chemokine Receptors but Is Independent of Integrins and Selectins"
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| 9:25 pm - 9:30 pm |
Discussion
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
Chemokine Control of Immune Activation and Disease
Discussion Leaders: Andrew Luster (Massachusetts General Hospital, USA) and Antal Rot (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
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| 9:00 am - 9:10 am |
Jeffrey Lian (Harvard University, USA)
"Targeting Lymph Node Niches to Enhance Type 1 Immune Responses to Immunization"
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| 9:10 am - 9:15 am |
Discussion
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| 9:15 am - 9:25 am |
Anna Barkaway (William Harvey Research Institute, United Kingdom)
"Age-Related Systemic Inflammation Supports Aberrant Neutrophil Transendothelial Migration"
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| 9:25 am - 9:30 am |
Discussion
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| 9:30 am - 9:40 am |
Ariadni Kouzeli (Cardiff University, United Kingdom)
"Identification of CXCL14-Responsive Cells in Healthy Peripheral Tissues"
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| 9:40 am - 9:45 am |
Discussion
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| 9:45 am - 9:55 am |
Marieke Pingen (University of Glasgow, United Kingdom)
"The Role of Dendritic Cells in the Dissemination of Mosquito-Transmitted Alphaviruses"
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| 9:55 am - 10:00 am |
Discussion
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| 10:00 am - 10:10 am |
Chie Miyabe (Massachusetts General Hospital, USA)
"Dectin-2-Induced CCL2 Production in Cardiac Macrophages Ignites Vascular Inflammation in a Murine Model of Kawasaki Disease"
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| 10:10 am - 10:15 am |
Discussion
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| 10:15 am - 10:25 am |
Carla Gibbs (Meharry Medical College, USA)
"CXCL14 Suppresses the Aggressive Phenotype in Triple Negative Breast Cancer (TNBC) Through CXCR4"
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| 10:25 am - 10:30 am |
Discussion
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| 10:30 am - 10:40 am |
Anna Vilgelm (Vanderbilt University, USA)
"Drug-Induced Senescence Promotes Anti-Tumor Immunity via the Induction of CCL5"
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| 10:40 am - 10:45 am |
Discussion
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| 10:45 am - 10:55 am |
Rod Rahimi (Massachusetts General Hospital / Harvard Medical School, USA)
"Aeroallergen-Induced Central Memory CD4+ T Cells Induce Allergic Airway Inflammation Independently of Lung-Resident Memory"
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| 10:55 am - 11:00 am |
Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: Career Pathways
Discussion Leaders: Caroline Sokol (Massachusetts General Hospital, USA) and Tamara Girbl (Queen Mary University of London, United Kingdom)
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| 1:30 pm - 2:30 pm |
Panel Discussion
Career Pathways
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Reinhold Förster (Hannover Medical School, Germany)
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Marcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
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Maud Deruaz (Massachusetts General Hospital / Harvard Medical School, USA)
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Joanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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