SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:45 pm - 9:30 pm | TRANSPORT |
| Discussion Leader: Ruma Banerjee (University of Nebraska) |
7:45 pm - 8:00 pm | Welcome |
8:00 pm - 8:45 pm | Doug Rees (CallTech)
"Structural studies of the ABC transport system for vitamin B12 in E. coli" |
8:45 pm - 9:30 pm | Soren Moestrup (Univ. of Ärhus)
"Structure and Function of Cobalamin Transport Receptors" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ISOMERASES |
| Discussion Leader: Wolfgang Bückel (University of Marburg) |
9:00 am - 9:40 am | Neil Marsh (University of Michigan)
"Exploring the relationship between structure and catalysis in glutamate mutase" |
9:40 am - 10:20 am | Perry Frey (University of Wisconsin)
"Adenosylcobalamin and Radicals in Enzymatic Sites" |
10:20 am - 11:00 am | Coffee Break and Group Photo |
11:00 am - 11:40 am | Tetsuo Toraya (Okayama University)
"Structures and action mechanism of coenzyme B12-dependent diol and glycerol dehydratases" |
11:40 am - 12:20 pm | Kurt Warncke (Emory University)
"Structure of Radical Pair Intermediates and the Mechanism of Catalysis in Adenosylcobalamin-Dependent Ethanolamine Deaminase" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | B12 AND RELATED SYSTEMS |
| Discussion Leader: Bernhard Jaun (ETH-Zürich) |
7:30 pm - 8:10 pm | Rolf Thauer (Max Planck Institute, Marburg)
"Structure and function of methyl-coenzyme M reductase" |
8:10 pm - 8:50 pm | Stephen Ragsdale (University of Nebraska)
"Methyl-CoM Reductase and the Nickel Corphin F430: Metal and Ligand Based Reactivity" |
8:50 pm - 9:30 pm | Joe Kryzcki (Ohio State University)
"Pyrrolysine: a new genetically encoded amino acid in methylamine:corrinoid methyltransferases" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | B12 AND GENE REGULATION |
| Discussion Leader: Cathy Drennan (MIT) |
9:00 am - 9:40 am | Ronald Breaker (Yale) "Riboswitches that Sense Coenzyme B12 and Other Fundamental Metabolites" |
9:40 am - 10:20 am | Francisco Murillo (Universidad de Murcia) "B12 and light-regulated gene expression in the bacterium Myxococcus xanthus" |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Poster Talk: Monica Vlasie (University of Nebraska) "When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl-CoA mutase" |
11:20 am - 11:40 am | Poster Talk: Gregory Havemann (University of Florida) "Polyhedral Organelles Involved in Coenzyme B12-Dependent Degradation of 1,2-Propanediol in Salmonella enterica Serovar Typhimurium LT2" |
11:40 am - 12:00 pm | Poster Talk: Julien Maillard (Ecole Polytechnique Federal de Lausanne) "Corrinoid-dependent Reductive Dehalogenases: genetic mobility and biochemical perspectives" |
12:00 pm - 12:20 pm | Poster Talk: Stephanie Dawes (University of Witwatersrand Medical School, Johannesburg) "The ribonucleotide reductases of Mycobacterium tuberculosis" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CHEMICAL AND COMPUTATIONAL MODELS |
| Discussion Leader: Antonio Pierik (Marburg) |
7:30 pm - 8:10 pm | Wilfred van der Donk (University of Illinois)
"Mechanistic studies on the vitamin B12-catalyzed dechlorination of chloroalkenes" |
8:10 pm - 8:50 pm | Piotr Paneth (Technical University of Lodz)
"Theoretical studies of tunneling hydrogen isotope effect in methylmalonyl-CoA mutase" |
8:50 pm - 9:30 pm | Bernhard Golding (University of Newcastle)
"The Mechanism of 2-Methyleneglutarate Mutase - Whatever Remains, However Improbable, Must be the Truth" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOSYNTHESIS |
| Discussion Leader: Martin Warren (University of London) |
9:00 am - 9:40 am | Martin Warren (University of London)
"Multiple pathways for the biosynthesis of the corrin ring component of cobalamin" |
9:40 am - 10:20 am | Heidi Schubert (University of Utah)
"Building B12: Structures and mechanisms in tetrapyrrole biosynthesis" |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Jorge Escalante Semerena (University of Wisconsin) "New insights into nucleotide loop assembly and 5,6-dimethylbenzimidazole synthesis" |
11:40 am - 12:20 pm | Tom Bobik (University of Florida)
"Interaction of the human methionine synthase reductase and cob(I)alamin adenosyltransferase in coenzyme B12 synthesis" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | B12 AND MEDICINE |
| Discussion Leader: David Rosenblatt (McGill University) |
7:30 pm - 8:10 pm | Roy Gravel (University of Calgary)
"Cloning genes in disorders of cobalamin metabolism based on analysis of prokaryotic gene arrangements" |
8:10 pm - 8:50 pm | Ebba Nexø (Ärhus Universitetshospital)
"Transcobalamin - the key cobalamin transporter in humans" |
8:50 pm - 9:30 pm | Chuck Grissom (University of Utah)
"Fluorescent Cobalamin Conjugates for Tumor Imaging and Intracellular Trafficking" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SPECTROSCOPIC APPROACHES |
| Discussion Leader: Christoph Kratky (University of Graz) |
9:00 am - 9:40 am | Thomas Brunold (University of Wisconsin)
"Spectroscopic and Computational Insights into the Biosynthesis and Reactivity of AdoCbl" |
9:40 am - 10:20 am | Bernhard Krauetler (University of Innsbruck)
"B12 - an Organometallic Chameleon" |
10:20 am - 11:00 am | Coffee Break |
11:00 am - 11:40 am | Ken Brown (Ohio University)
"Theoretical and Experimental Approaches to Mechanochemical Triggering in Ribonucleotide Reductase" |
11:40 am - 12:20 pm | George Reed (University of Wisconsin)
"Intermediates in coenzyme B12 dependent reactions: biradicals, triplet states and things in between" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
8:00 pm - 9:30 pm | THE TWO FACES OF COBALAMINS |
| Discussion Leader: Martha Ludwig (University of Michigan) |
8:00 pm - 8:45 pm | JoAnne Stubbe (MIT) "Ribonucleotide Reductase" |
8:45 pm - 9:30 pm | Rowena Matthews (University of Michigan)
Alexander M. Cruickshank Lecture
"The role of cobalamin in methionine synthase in modulating conformational ensembles" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |