Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Revaluation of Historical Findings Based on Recent Advances in the PDE Field
Discussion Leader: Martina Schmidt (University of Groningen, The Netherlands)
7:40 pm - 8:05 pm
Joseph Beavo (University of Washington, United States)
"How Do cAMP and PDEs Coordinate Compartmentalized, Multistep Processes?"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
George Baillie (University of Glasgow, United Kingdom)
"Looking to the Future: Novel Technologies for Modulating Phosphodiesterase Activity"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Emily Willems (Hasselt University , Belgium)
"Segregating PDE4 Genetics and Epigenetics in Alzheimer's Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Elka Kyurkchieva (University of Glasgow, United Kingdom)
"Investigating Bifunctional PDE4 Degraders for the Treatment of Acrodysostosis Type 2"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biosensors and Structure
Discussion Leader: Rick Cote (University of New Hampshire, United States)
9:00 am - 9:20 am
Manuela Zaccolo (University of Oxford, United Kingdom)
"Signalling at the Nanoscale: cAMP Compartmentation by PDEs"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andreas Bock (Leipzig University, Medical Faculty, Germany)
"Using Genetically Encoded Nanorulers to Map cAMP Signaling at the Nanometer Scale"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jin Zhang (University of California, San Diego, United States)
"Illuminating the Biochemical Activity Architecture of the Cell"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Christine Gee (Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Germany)
"Photoactivatable Adenylyl Cyclase with No Dark Activity Reveals Unexpected Population Effects of cAMP"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Julia Gorelik (Imperial College London, United Kingdom)
"Role of Stretch-Responsive Nanodomains of Ventricular Cardiomyocytes in Healthy and Failing Hearts"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Hengming Ke (University of North Carolina at Chapel Hill, United States)
"Novel PDE Inhibitors Targeting Alzheimer's Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Roberta Kurelic (University Medical Center Hamburg-Eppendorf, Germany)
"Real-Time Visualization of cAMP Transfer Between Different Subsets of T Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Finn Olav Levy (University of Oslo, Norway) and Leila Gobejishvili (University of Louisville, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intracellular Cyclases and Extracellular Cyclic Nucleotide Signaling
Discussion Leader: Finn Olav Levy (University of Oslo, Norway)
7:30 pm - 7:50 pm
Rosely Godinho (Escola Paulista de Medicina/ Universidade Federal de São Paulo, Brazil)
"cAMP Efflux and Extracellular cAMP-Adenosine Pathway as Important Modulators of Intracellular cAMP Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Andreas Guse (University Medical Center Hamburg-Eppendorf, Germany)
"cAMP Meets NAADP Signaling: A Redox Story"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Laurinda Jaffe (University of Connecticut, United States)
"Regulation of Meiosis in Ovarian Follicles by cGMP and cAMP"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Jordan VerPlank (Uniformed Services University of the Health Sciences, United States)
"Raising cGMP to Activate the Proteasome and Treat Proteotoxic Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Late-Breaking Topic
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cyclic Nucleotide Effectors
Discussion Leader: Thomas Brand (Imperial College London, United Kingdom)
9:00 am - 9:20 am
John Scott (University of Washington School of Medicine, United States)
"Local cAMP Signaling Pathologies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kimberly Dodge-Kafka (UConn Health, United States)
"Perinuclear Signaling Orchestrated by the mAKAPbeta Signalosome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Hong Yan (Faculty of Science and Engineering, The Netherlands)
"The Role of EPAC1 in Ferroptosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Darren Browning (Medical College of Georgia, Augusta University, United States)
"PKG2 as the Central cGMP Effector in the Intestine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ying Xu (Rutgers, The State University of New Jersey, United States)
"The Diversity of Phosphodiesterase 2 Dependent cAMP/cGMP Signaling in Mitochondria in Mild Cognitive Impairment"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathogen and Other Non-Mammalian PDEs
Discussion Leader: Claire Lugnier (Université de Strasbourg/CNRS, France)
7:30 pm - 7:50 pm
Rob Leurs (Vrije Universiteit Amsterdam, The Netherlands)
"New Chemical Biology Tools to Target Parasitic and Human PDEs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Masahiro Kasahara (Ritsumeikan University, Japan)
"Role of CAPE: A Protein Containing Both Adenylyl Cyclase and cAMP Phosphodiesterase Domains in Land Plants that Reproduce Using Motile Flagellated Sperm"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Maria Rachele Ceccarini (University of Perugia, Italy)
"Phosphodiesterases Genes Variants and Anorexia Nervosa: A Possible Involvement?"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Thomas Rich (University of South Alabama, United States)
"Systems Approaches to Understanding cAMP Signaling Networks"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
PDE1, PDE10 and PDE11
Discussion Leader: Leila Gobejishvili (University of Louisville, United States)
9:00 am - 9:10 am
Late-Breaking Topic
9:10 am - 9:15 am
Discussion
9:15 am - 9:30 am
Charles Hoffman (Boston College, United States)
"Analysis of the Impact of Mutations in PDE11A4 on Sensitivity to a Panel of Structurally-Related Inhibitors"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Elvis Amurrio (University of Maryland School of Medicine, United States)
"Catalytic Inhibitors of PDE11A4 Dramatically Alter Its Subcellular Compartmentalization"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Chen Yan (University of Rochester, United States)
"Regulation of Cardioprotective cAMP Signaling: Molecular Insights and Therapeutic Potential"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Pierre Vincent (CNRS, France)
"Cross-Pathway Signal Integration Through cGMP and Calcium-Regulated Phosphodiesterases in Neurons"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gretchen Snyder (Intra-Cellular Therapies Inc, United States)
"PDE1 Inhibitors in the Treatment of Neuroinflammation and Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Sean Smith (Merck, United States)
"The Preclinical Profile and Clinical Evaluation of the PDE10A Inhibitor MK-8189 in Patients with an Acute Episode of Schizophrenia"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Mikolaj Matloka (Celon Pharma SA, Poland)
"CPL’36, a PDE10A Inhibitor, for the Treatment of Schizophrenia and L-DOPA Induced Dyskinesias in Parkinson’s Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
PDE7, PDE8 and PDE9
Discussion Leader: Stefan Brocke (UConn Health, United States)
7:30 pm - 7:50 pm
George Gaitanaris (Omeros Corporation, United States)
"PDE7 Inhibitors on Substance Use Disorders"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Hanting Zhang (Qingdao University School of Pharmacy, China)
"Identification of PDE7 as a Novel Target for Treatment of Alcoholism"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Cristina E. Molina (University Medical Center Hamburg - Eppendorf, Germany)
"Decoding Atrial Dance: Role of PDE8B in Controlling Ca2+ Dynamics and Arrhythmias in Human Atrial Myocytes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Sumita Mishra (Johns Hopkins University School of Medicine, United States)
"PDE9 in the Heart"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The PDE4 Family
Discussion Leader: Coleen Atkins (University of Miami, United States)
9:00 am - 9:20 am
Tatiana Lipina (University of Toronto, Canada)
"PDE4B M220T Variant Increases Vulnerability to Post-Traumatic Stress Disorder Phenotypes in Mice"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Wito Richter (University of South Alabama, United States)
"The Role of Individual PDE4 Subtypes in the Therapeutic and Adverse effects of PAN-PDE4 Inhibitors: Insights from PDE4 Knockout Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yang Kevin Xiang (University of California, Davis, United States)
"Regulation of Nuclear cAMP in Hippocampal Neurons and Alzheimer’s Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Nikoleta Pavlaki (Boston Children’s Hospital, Harvard Medical School, United States)
"Gene Therapy with PDE4B Ameliorates Heart Failure and Arrhythmias by Improving Subcellular cAMP Compartmentation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Diego Montoya-Durango (University of Louisville, United States)
"RNA Sequencing Identifies a Novel Pathway Contributing to the Therapeutic Efficacy of PDE4 Inhibition in a Mouse Model of Alcohol-Associated Liver Disease"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Late-Breaking Topic
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Late-Breaking Topic
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Late-Breaking Topic
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
PDE2 and PDE3 Crosstalk
Discussion Leader: Kjetil Tasken (Oslo University Hospital, Norway)
7:30 pm - 7:50 pm
Delphine MIKA (INSERM U1180, France)
"Cyclic AMP Turnover and Cardiac Pacemaker Activity: Role of Phosphodiesterases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Donald Maurice (Queen's University, Canada)
"PDE2, PDE3 and PDE4 have Selective Roles in Adipogenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Maike Frye (University Medical Center Hamburg-Eppendorf, Germany)
"Endothelial Cell Type-Specific Functions of Phosphodiesterase 2A"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Late-Breaking Topic
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure