Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Probing the Logic of Cell Guidance from Biochemical Reconstitutions to Embryonic Development
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Molecular and Cellular Mechanisms Controlling Polarity and Motility of Zebrafish Primordial Germ Cells"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"A Physics View on the Coupling Between Membrane Shape/Organization and Actin Dynamics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Self-Organization of Chemotactic Gradients and the Migration Machinery
9:00 am - 9:25 am
"Where Do Chemotactic Gradients Come From?"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Excitable Networks in Directed Cell Migration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Repellent Cell Guidance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Optogenetic Approaches to Disentangle Polarity and Directional Sensing Pathways in Neutrophil Chemotaxis"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Composition-Dependent Activities of Actin Regulatory Signaling Clusters"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Gip1 Structure Reveals the Molecular Mechanism of Trimeric G Protein Shuttling for Eukaryotic Broad Range Chemotaxis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulation of Cell Migration and GTPase Function Through Mechanical Control of RNA Localization"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Getting Cells and Tissues into Shape
7:30 pm - 7:55 pm
"Connections Between Morphogen Signaling, Cell Mechanics and Metabolism in Drosophila Tissue Morphogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Chemotaxis: Linking Cell Shape, Behaviour and Strategy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Cell Morphological Motif Detector for 3D Microscopy Images"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Planar Signaling Mechanisms that Coordinate Individual Cell Movements for Epithelial Migration"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cells Working Together to Coordinate Movement
9:00 am - 9:25 am
"Mechanisms of Collective, Cooperative, Cell-on-Cell Migration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cell-Cell Interactions Direct Neural Superposition in the Drosophila Eye"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"ERK Activation Waves Mediated by Intercellular Mechanical Signaling During Collective Cell Migration"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Supracellular Contraction at the Rear of Neural Crest Cell Groups Drives Collective Chemotaxis"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Predicting Where Tumour-Stroma Boundaries Will Break Down, Leading to Collective Cancer Cell Invasion"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dual Functions of the Discoidin Domain Receptor in Coordinating Cell-Matrix Adhesion and Polarity During Migration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Misshapen Coordinates Protrusion Restriction and Actomyosin Contractility During Collective Cell Migration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk in Cell Guidance
7:30 pm - 7:55 pm
"The Neutrophil Envelope as a Signaling Hub During Neutrophil Chemotaxis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Cellular Energetics During 3D Migration and Metastasis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Collagen-Bound Epidermal Growth Factors Control Directed Cell Migration"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Nondegradative Ubiquitination Is a Novel Signaling Mechanism Translating Guidance Cues into Axon Turning"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Migration in Pathophysiology
9:00 am - 9:25 am
"Cellular and Molecular Mechanisms of Cancer Invasion and Metastasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Microenvironmental Control of Tumor Cell Behaviour In Vivo "
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"MYO10 Aberrant Methylation and Overexpression in Leader Cells Regulates Lung Cancer Collective Cell Invasion and Fibronectin Patterning"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Cofilin Facilitates Remodeling and Front-Back Polarization of Tension in Stress Fiber Networks During Migration"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Cancer Invasion Plasticity: Collective to Amoeboid Transitions"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Jamming Transition in Physiology and Pathology"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanical Integration of Shape and Movement
7:30 pm - 7:55 pm
"Mechanical Regulation of Cell Division During Collective Migration in the Zebrafish Epicardium"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Regulating the Cytoskeleton in Mesenchymal Cells to Achieve Chemotaxis, Haptotaxis and Durotaxis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Cell-Extrinsic Mechanical Forces Induce Neutrophil Polarization in the Absence of Leading-Edge Actin Assembly Pathways"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Macrophages Chew Before Swallowing"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Movement During Inflammation and Regeneration
9:00 am - 9:25 am
"Cellular Dynamics During Hydra Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Onset and Resolution of Inflammation in the Wound and Tumor Microenvironment"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"A Conserved Major Facilitator Superfamily Member Orchestrates a Subset of O-Glycosylation to Aid Macrophage Tissue Invasion"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Nuclear Positioning Facilitates Amoeboid Migration Along the Path of Least Resistance"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Cytoskeletal Crosstalk During Directed Migration"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Persistent and Polarized Global Actin Flow During Cell Migration Controls Directionality"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Phagocytic Dynamics and Tissue Clearance in Early Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
How Cells Generate Polarity and Persistence
7:30 pm - 7:55 pm
"Time-Stable Gradients in Cortical Actin Density Impose Cell Polarity and Ensure Cell Migration Persistence"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Cellular Mechanisms Ensuring Robust Tissue Migration Through Changing Environments"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Coordination of Actin Networks by a Receptor-Ligand Complex Guides Dendrite Morphogenesis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Organelle Positioning, Active Compensation of Nuclear Hindrance, and Maintenance of Cell Integrity During Fast Directed Migration Through Complex Environments"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure