Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: DNA Damage Response and Cancer
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 8:45 pm
"Mechanistic Understanding and Targeting of Cancer Cell Addictions to Stress-Tolerance Pathways"
8:45 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mutational and Repair Processes
9:00 am - 9:20 am
"Nuclear and Chromatin Dynamics for Heterochromatin Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Rad51 and Rad59 Cooperate to Promote One Unified Pathway of Alternative Lengthening of Telomeres"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Promiscuous Synthesis During Repair of Chromosome Breaks: What Goes in, When, and Why?"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"From Statistical Models to Biological Mechanisms of Human Mutation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Pervasive Segregation of DNA Lesions Generates Genetic Diversity in Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Break-Induced Replication Mechanisms in Mammalian Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Mechanisms of Genome Editing in Human Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"NucleaSeq: Massively-Parallel Biophysical Profiling of Natural and Engineered CRISPR Nucleases"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Complex Genome Editing In Vivo via Lipid Nanoparticle Delivery of CRISPR-Cas9"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sensitization of HR-Deficient Cancer Cells by Targeting Nucleotide Metabolism"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcription and Replication Collisions
9:00 am - 9:20 am
"BRCA2 Promotes RNA-DNA Hybrids Resolution at DNA Double-Strand Breaks to Facilitate Homologous Recombination"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"R-Loops and Aberrant RNA Splicing Cause Cerebellar Transcriptional Collapse in Genome Instability-Induced Neurodegeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Transcription-Induced Mutagenesis in Bacteria"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A Model for How Replicative Polymerase Deficiency Affects Genome Integrity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dissecting the Molecular Mechanisms of DNA Damage Response Pathways"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mre11 Suppresses Genome Instability at Oncogene-Induced R Loops"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosome Rearrangements in Cancer
7:30 pm - 7:50 pm
"The Role of Replication Regulation in Damage and Mutation in Cancer Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Etiology of Chromosomal Rearrangements"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Functional Link Between DNA Replication Stress and Mitotic Errors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"REV1 Promotes Two Distinct Mechanisms of Damage Tolerance in Drosophila "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Burden and Signatures of Somatic Mutations in Healthy Individuals"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Response and DNA Damage
9:00 am - 9:20 am
"Targeting Homologous Recombination: A New Synthetic Lethal Therapeutic Paradigm"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cellular Responses to Endogenous Replication Stress"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Repair Landscape and Induction of the Inflammatory Response"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"When V(D)J Goes Astray: Etiology of the Chromosomal Translocations that Drive B-Cell Malignancies"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo "
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Interferon-Stimulated Gene 15 Accelerates DNA Replication Leading to Chromosomal Breakage"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Targeting Gene Amplifications to Exploit DDR for Cancer Therapy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Susceptibility from Repair Processes and Cancer Treatments
7:30 pm - 7:50 pm
"Investigating Factors at the Interface of DNA Repair and Replication"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Exploring Signaling Networks for Novel DNA Repair Regulatory Mechanisms"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"A DNA Polymerase for Stress Relief and Cancer Suppression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mechanisms Underlying the Formation of Complex Chromosomal Rearrangements"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Repair Fate Mapping of Broken Ends in Non-Dividing Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Structures and DNA Damage
9:00 am - 9:20 am
"Mechanisms of Genome Instability Mediated by Simple DNA Repeats"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Dynamics and Regulation of DNA Repair at Complex Chromosomal Breaks"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"RAD52 Protein: A Protector of Stalled Replication Forks"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Breaking Bad: Aberrant DNA Repair and Repeat Expansion in the Fragile X-Related Disorders"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"DNA End-Joining Involving DNA and RNA Substrates"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"SUMOylation of DNA Repair Proteins at Collapsed Forks Mediates Relocation to Nuclear Pore Complexes to Promote Repair"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Targets for Cancer Therapies
7:30 pm - 7:50 pm
"Linking DNA Repair and Anticancer Immune Response to Design Rational Therapeutic Approaches"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"APOBEC3A Is a Prominent Cytidine Deaminase Active in Human Cancers"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Monitoring APOBEC3A Activity in Patient Tumors for Targeted Therapy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"TGFβ Regulation of Alternative End Joining"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure