Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Replication Gaps in Signaling, Repair and Disease
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
"Mind the Gap – Daughter-Strand Gaps as Sites of Damage Bypass and Damage Signaling"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"The Impact of Single-Strand Break Repair on Transcription, Replication, and Disease"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Checkpoint Responses
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functions of Biomolecular Condensates Assembled in Response to DNA Damage"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Checking the Completion of DNA Replication at the S/G2 Transition"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Processing DNA Damage During Mitosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
"Molecular Switches in Antibody Gene Diversification"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"ATR Kinase Inhibitors Induce Thymineless Death in CD8+ T Cells"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Base Excision Repair Mediated Regulation of the Replication-Stress Induced Intra S-Phase Checkpoint"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Aberrant Activity of the APOBEC3A Cytidine Deaminase Causes Genome-Wide Indels and Altered DNA Methylation"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage and Structures Engaging Repair vs. Bypass Mechanisms
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Two Interaction Sites Between XPA and RPA Sculpt the Precision Complex in Human Nucleotide Excision Repair"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genome Damage and Mutations Arising from Persistent Ribonucleotides in DNA"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"DNA End Manipulation by Pol Theta"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"RAD51 Paralog Function in DNA Damage Tolerance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Single-Molecule Insights into Stressed DNA: Supercoiling, Secondary Structures and Topological Problems"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair, Replication and Cancer Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Impact of Lagging Strand ssDNA Gaps on Replication Fork Protection and Genomic Stability"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Catalytically Inactive PARP2 Blocks Nick Repair During Replication and Cause Lethal Anemia in Mice"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality with BRCA Deficiency"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Linking DNA Replication for Dynamics with Chemotherapy Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Pathways that Defy DNA Under-Replication"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Blocks versus Breaks: Cancer and Toxicity Pivot Depending on Aag Levels"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"High-Throughput Screening Strategy Identifies Novel Regulator of Replication Stress Response"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chromosomal Dynamics, DNA Damage Signaling and Immune Responses
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Mechanism of Site-Specific Ubiquitin Removal in the Fanconi Anemia Pathway"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Message in a Small Extracellular Vesicle: An Unexpected Cargo Informs Innate Immune Cells About Cancer Cell DNA Damage"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Signatures of TGFß Competency and DNA Repair Predict Response to Anti-PD1 and Anti-PDL1 Therapies"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"New Insights Into Innate Immune Sensing During Tumorigenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Regulation of APOBEC3A Mutagenesis and Inflammation by the DNA Damage Response"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication, Collisions and Recovery
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Causes and Consequences of Replication Stress"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Landscapes: Implications for Genome Instability Mechanisms"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"When Repair Accidents Lead to DSB’s"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Epigenetic Control of G Quadruplex DNA"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Molecular Mechanisms in Transcription-Coupled DNA Repair"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Mechanisms of DNA Repeat Expansions: From Yeast to Human Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Uracil Excision and Abasic Site Accumulation Dictate Stalled Fork Stability in BRCA2-Deficient Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"BRCA1 Mutations and Polymerase Theta Addiction"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
CRISPR Screens to Gene Editing in Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Transforming Medicine: In Vivo and Ex Vivo Therapeutic Gene Editing"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Identifying Genetic Interactions for FA Through Genetic Screens"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Mapping the DNA Repair Processes that Enable CRISPR-Based Genome Editing"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Mechanism of DNA End Sensing by the MRE11 Complex: Implications for CRISPR-Based Genome Editing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Synthetic Lethality for Platinum-Induced DNA Damage Using CRISPRi Screens and Nanoparticle Delivery"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer, Aging and Neurodegeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genome Stability in Aging, Inheritance and Disease: An Organismal Perspective from C. elegans"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Endogenous DNA Damage as a Driver of Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Persistent Activation of the DNA Damage Response in LRRK2-Related Parkinson’s Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"The DNA Damage Response in Senescent Cells – Impacts on Genome Integrity, Aging and Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Extrachromosomal DNA: An Emerging Hallmark in Human Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The Processing of 8-Oxoguanine at Telomeres Promotes Cellular Senescence"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"DNA Damage-Based Mechanisms and Therapeutics for Age-Relative Neurodegenerative Diseases"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomic Instability and Emerging Targets for Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Linking RNA Processing Defects and Genome Integrity"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Replication Stress as a Potential Driver of Clonal Hematopoiesis in 9/11 Firefighters"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Expanding the Scope of DNA Repair Factors - Novel Roles and Applications"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Exploring the Interface Between the Mtp53-PARP Axis and DNA Replication Regulation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Translation to Clinical Trials: How Do We Accelerate Progress?"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure