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Saturday
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| 1:00 pm - 5:00 pm |
Arrival and Check-in
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| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
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| 3:45 pm - 4:30 pm |
Keynote Session: Base Excision Repair and Cancer
Discussion Leader: Lindsey Jackson (Penn State College of Medicine, USA)
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| 3:45 pm - 4:20 pm |
Joann Sweasy (University of Arizona Cancer Center, USA)
"Base Excision Repair and Cancer"
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| 4:20 pm - 4:30 pm |
Discussion
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| 4:30 pm - 6:00 pm |
Poster Session
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| 6:00 pm - 7:00 pm |
Dinner
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| 7:30 pm - 9:30 pm |
DNA Damage Response in Cancer
Discussion Leaders: Shrabasti Roychoudhury (Dana-Farber Cancer Institute, USA) and Connor McBrine (Yale University, USA)
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| 7:30 pm - 7:45 pm |
Emily Cybulla (St. Louis University School of Medicine, USA)
"Identifying a RAD18/UBC13-dependent Mechanism of Replication Fork Recovery to Modulate Chemoresponse in BRCA1-Deficient Cancers"
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| 7:45 pm - 7:50 pm |
Discussion
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| 7:50 pm - 8:05 pm |
Ke Cong (UMass Medical School, USA)
"Replication Gaps are a Key Determinant of PARP Inhibitor Synthetic Lethality with BRCA Deficiency"
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| 8:05 pm - 8:10 pm |
Discussion
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| 8:10 pm - 8:25 pm |
Victoria Brown (Blueprint Medicines, USA)
"CDK2 Coordinates Collapsed Replication Fork Repair in CCNE1 Amplified Ovarian Cancer Cells via Homologous Recombination"
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| 8:25 pm - 8:30 pm |
Discussion
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| 8:30 pm - 8:40 pm |
John Krais (Fox Chase Cancer Center, USA)
"Exploring Mutation-Specific BRCA1 Localization Defects"
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| 8:40 pm - 8:45 pm |
Discussion
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| 8:45 pm - 8:55 pm |
Ashna Dhoonmoon (Pennsylvania State University College of Medicine, USA)
"The KU-PARP14 Axis Differentially Regulates Nascent Strand Resection at Stalled Replication Forks by the MRE11 and EXO1 Nucleases"
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| 8:55 pm - 9:00 pm |
Discussion
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| 9:00 pm - 9:10 pm |
Gemma Moore (Yale University, USA)
"BRCA2 Reversion Alleles in BRC Repeats Confer PARPi Resistance via Homology-Directed Repair, not Fork Protection"
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| 9:10 pm - 9:15 pm |
Discussion
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| 9:15 pm - 9:25 pm |
Anna Palovcak (University of Miami, USA)
"Protein Interactions of Fanconi Anemia Protein FANCA in the DNA Double-Strand Break Repair Response"
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| 9:25 pm - 9:30 pm |
Discussion
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Sunday
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| 7:30 am - 8:30 am |
Breakfast
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| 9:00 am - 11:00 am |
DNA Replication and Repair Pathway Choice
Discussion Leaders: Beth Osia (City of Hope, USA) and Catherine Miller (Harvard, USA)
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| 9:00 am - 9:15 am |
Carolyn Milano (New York University, USA)
"A Hop1-PHD/WHD Domain Affects Repair of Meiotic DSBs via Direct Interaction with Unmodified Histones"
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| 9:15 am - 9:20 am |
Discussion
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| 9:20 am - 9:35 am |
Ryan Barnes (University of Pittsburgh, USA)
"Telomeric 8-Oxo-Guanine Drives Rapid Premature Senescence in the Absence of Telomere Shortening"
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| 9:35 am - 9:40 am |
Discussion
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| 9:40 am - 9:55 am |
Rachana Tomar (Vanderbilt University, USA)
"Correlating the Mutagenic Spectrum of the Aflatoxin B1-Fapy-dG Adduct with Sequence-Specific Modulation of Adduct Conformation and Configuration in DNA"
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| 9:55 am - 10:00 am |
Discussion
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| 10:00 am - 10:15 am |
Hannah Trost (City of Hope Medical Center - Irell and Manella Graduate School, USA)
"Distinct Pathways Suppress Repeat-Mediated Deletions"
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| 10:15 am - 10:20 am |
Discussion
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| 10:20 am - 10:35 am |
Elena Martin Doncel (Københavns Universitet (KU), Denmark)
"POLA1 Prevents Post-Replicative ssDNA Gaps Caused by Strand Uncoupling"
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| 10:35 am - 10:40 am |
Discussion
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| 10:40 am - 10:55 am |
Shiba Dandpat (LUMICKS USA Inc., USA)
"Dynamic Single-Molecule Approach to Directly Visualize the Molecular Mechanisms of DNA Repair Processes"
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| 10:55 am - 11:00 am |
Discussion
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| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
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| 12:30 pm - 1:30 pm |
Lunch
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| 1:30 pm - 2:30 pm |
Mentorship Component: Navigating Career Independence
Discussion Leader: Matthew Volpe (Harvard University, USA)
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| 1:30 pm - 2:30 pm |
Panel Discussion
Navigating Career Independence
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Angela Eggleston (Nature, USA)
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Asli Muvaffak (GlaxoSmithKline, USA)
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Chris Richardson (UC Santa Barbara, USA)
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Alessandro Vindigni (Washington University School of Medicine, USA)
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| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
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| 3:00 pm |
Seminar Concludes
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