Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Complexities of Epigenetic Mechanisms
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Quantifying the Landscape and Dynamics of the Acetylome"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"A New Mode of Xist Action"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contribution of the Epigenome to Cardiac Development and Regeneration
9:00 am - 9:20 am
"Molecular Drivers of Cardiomyocyte Maturation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Hippo Signaling in Epigenetic Regulation of Heart Development and Regeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
"A Lamin A/C Mutation Responsible for a Cardiomyopathy Impairs Epigenetic Regulation of Heart Development: Rescue of the Mouse Phenotype by a Chromatin Modifier Inhibitor"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Single-Cell Genomics Analysis of Postnatal Heart Development and Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Epigenetic Regulation of Cardiomyocyte Differentiation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TET Inactivation Perturbs Long-Range Chromatin Interactions During Cardiac Development "
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Transcriptional and Epigenetic Networks in Cardiovascular Lineage Commitment and Differentiation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Methylation and Editing in Cardiovascular Disease
7:30 pm - 7:50 pm
"RNA Methylation in the Regulation of Cardiac Hypertrophy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"FTO-Regulated Cardiac Epitranscriptome in Disease and Therapeutics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"RNA Methylation in Endothelial Cell Biology and Function"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"TAZ: A New Player in the Epigenetic Regulation of Cardiomyocyte Hypertrophy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"RNA Modifications in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Impact of Mitochondria, Fat and Sex on the Epigenome in the Heart
9:00 am - 9:20 am
"Regulation of Histone Deacetylase 4 by Lipid Droplet Associated Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sex Based RNA Methylation in the Heart"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Hypermethylation of Mitochondrial DNA in Vascular Smooth Muscle Cells Impairs Arterial Contraction"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Protein Arginine Methyltransferases Regulate Cardiac Function and Energy Metabolism"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Recruitment of Metabolic Enzymes to Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeting Transcription in Heart Failure"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mitochondria, Metabolism and Epigenetics in Cellular Reprogramming"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
The Role of Epigenetics in the Pathogenesis of Vascular Disease
4:00 pm - 4:20 pm
"Uncovering New Mechanisms of Vascular Disease in the Non-Coding Genome"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:50 pm
"The Role of RNA Modification in Vascular Regeneration"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
"Mechanical Stress, Endothelial Inflammation and Atherogenesis"
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
"Regulation of Angiogenesis by lncRNAs"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Remodeling and Architecture in Cardiovascular Disease
9:00 am - 9:20 am
"Understanding How Genome Organization Instructs Cardiac Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Hypertrophic Growth by the Smyd Family of Histone Methyltransferases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Chromatin Compartment Dynamics in a Halploinsufficient Model of Cardiac Laminopathy"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Integrating Structure and Accessibility in Models of Cardiac Chromatin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Transcriptomic and Epigenetic Profiling Reveal a Ground State of Cardiomyocyte Crucial for Heart Maturation and Regeneration"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identification and Functional Epigenetic Modulation of Chromatin Interactions in Cardiac Myocytes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Targeting Nucleosomes and Enhancer RNAs for Direct Fibroblast Reprogramming and Anti-Fibrotic Therapy
7:30 pm - 7:50 pm
"Molecular Barriers to Direct Cardiac Reprogramming"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Regulation of Cardiac Gene Reprogramming in Response to Cell Signaling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Targeting Enhancer-Signaling in Cardiac Fibrosis and Heart Failure Pathogenesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"The Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Therapy for Heart Disease via Targeting Enhancer-Associated Long Noncoding RNAs"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional Control of Cardiovascular Disease
9:00 am - 9:20 am
"New Cardiac Specific Non-Coding RNAs Regulating Cardiac Transcription Factors and Epigenetics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Dynamics of the Epigenome in Cardiac Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"In Vivo Function of Flow-Responsive cis-DNA Elements in the Endothelial Nitric Oxide Synthase Gene: A Role for Chromatin-Based Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Molecular Mechanisms of Heart Failure Dissected by Single Cell RNA Seq Analysis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Acetyl-CoA Production by Specific Metabolites Promotes Heart Repair After Myocardial Infarction via Mediating Histone Acetylation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Using Epigenetics to Identify Genetic Determinants of Heart Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dnmt3a: An Epigenetic Regulator During Postnatal Angiogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Glucose-Sensitive Cadiokine/Myokine MG53 Impairs Multiorgan Insulin Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Epigenetic Therapies for Cardiovascular Disease
4:00 pm - 4:20 pm
"Reversible Protein Acetylation and Disease-Related Myocardial Remodeling "
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:40 pm
"Epigenetic Profiling of Cardiac Pacemaker Cells: Insights into the Origin and Regulation of Heart Rhythm"
4:40 pm - 4:45 pm
Discussion
4:45 pm - 5:05 pm
"Targeting Jumonji C Histone Lysine Demethylases in Pathological Cardiac Remodeling"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
"Multiomics Dissection of Heart Failure for the Development of Cardiovascular Precision Medicine"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
"Epigenetic Modifying Therapy for Cardiovascular Disease that Targets BET Proteins"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
