Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Keynote Session: Mechanobiology From Molecules to Cells 
 
 
 
						
7:40 pm - 8:20 pm 
	
"Tumor Cells Lack Rigidity Sensors and Are Mechanosensitive" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Mech(n)anobiology of Dendritic Cells" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:20 pm 
	
"How Cancers Exploit Mechanical Weakness in the Stroma" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Using Integrin Structure to Devise Therapeutic Interventions 
 
 
 
						
9:00 am - 9:20 am 
	
"New Structural Insights into Integrin Signaling" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Structure-Guided Design of Novel Integrin Antagonists" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Single Molecule FRET Measurement Reveals Integrin Activation Trajectory" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"Understanding Integrin Therapeutics Using cryoEM" 
 
 
 
						
11:10 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:30 am 
	
"Pleiotrophin's Interaction With aM I Domain is Activation State Dependent" 
 
 
 
						
11:30 am - 11:40 am 
	
Discussion
 
 
						
11:40 am - 11:50 am 
	
"Identification of a Lead Compound to Disrupt the Heterodimer Stability of ITGAV and ITGB5" 
 
 
 
						
11:50 am - 12:00 pm 
	
Discussion
 
 
						
12:00 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Imaging Dynamics of Cell-ECM interaction and Signaling 
 
 
 
						
7:30 pm - 7:40 pm 
	
Introduction by Discussion Leader
 
 
						
7:40 pm - 8:00 pm 
	
"Substitute Fascin for Fbronectin – Anchorage-Independent Assembly of Adhesion-like Structures Promoting Proliferation Signals in Cancer" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:30 pm 
	
"Geometric and Mechanical Constraints on Tissue Morphogenesis by the Extracellular Matrix" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 8:50 pm 
	
"Differential Activation and Mesoscale Organization of Integrin Nanoclusters in Focal Adhesions" 
 
 
 
						
8:50 pm - 8:55 pm 
	
Discussion
 
 
						
8:55 pm - 9:05 pm 
	
"The Molecular Dynamics of Single Integrin a5ß1 Heterodimers in Living Zebrafish Embryos" 
 
 
 
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						
9:10 pm - 9:25 pm 
	
"Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Tools and Approaches to Study Mechanotransduction 
 
 
 
						
9:00 am - 9:20 am 
	
"Identifying Context-specific, Tension-dependent Protein Complexes Within Focal Adhesions" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Probing the Mechanobiology of Wound Healing and Disease: Tools to Detect and Manipulate Fibronectin-integrin Interactions" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Cell-matrix Adhesion and the Cell-cycle" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"The Mechanics of Epithelial Monolayers: Buckling, Curling, and Tearing" 
 
 
 
						
11:10 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:40 am 
	
"Visualizing Mechanotransduction through Actin Filaments" 
 
 
 
						
11:40 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:00 pm 
	
"The Interplay Among Force, Focal Adhesions, and YAP" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"YAP/Rigidity and Apoptosis" 
 
 
 
						
12:20 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Membrane and Receptor Trafficking 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Turning over Active and Delivering New - Integrin Traffic and Cell Migration" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"Extracellular Vesicles: What Does Membrane Trafficking Have to do with It" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Tissue Fluidification in Breast Cancer Progression" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:10 pm 
	
"Altered Metabolism Coordinates Small Extracellular Vesicle Production and Invasive Behavior During Metastatic Seeding of Breast Cancer" 
 
 
 
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						
9:15 pm - 9:25 pm 
	
"Dissecting avß6 Internalization and Trafficking" 
 
 
 
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Matrix Receptors in Fibrosis and Disease 
 
 
 
						
9:00 am - 9:20 am 
	
"SNED1: a Novel ECM Protein at the Intersection of Cancer and Development" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Integrin Signaling in Epithelial Cell Injury and Repair" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"The Collagen Receptor Discoidin Domain Receptor 1 Regulates Mitochondrial Oxidative Stress in Kidney Injury" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"Cancer Cell Response to Isolation Stress Leads to Secretion of a Fibronectin-enriched Niche that Supports Tumor Initiation" 
 
 
 
						
11:10 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:40 am 
	
"Interrogating Basement Membrane Regulation and Dynamics in the Kidney" 
 
 
 
						
11:40 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:00 pm 
	
"Pregnancy-associated Maternal Antibodies Against ß3 Integrins Cause Endothelial Cell Damage and Disrupt Sprouting Angiogenesis" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"Influence of JAK2V617F Mutation on the N-glycosylation Profile of a2 and ß1 Integrins in the Megakaryocyte and Platelet Lineages" 
 
 
 
						
12:20 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Matrix Receptors in Host-Tumor Interaction 
 
 
 
						
7:30 pm - 7:50 pm 
	
"Blood Vessel Control of Cancer Cells – New Ways for Old Roads" 
 
 
 
						
7:50 pm - 8:00 pm 
	
Discussion
 
 
						
8:00 pm - 8:20 pm 
	
"The Extracellular Matrix Supports Cancer Cell Growth Under Amino Acid Starvation" 
 
 
 
						
8:20 pm - 8:30 pm 
	
Discussion
 
 
						
8:30 pm - 8:50 pm 
	
"Targeting the Metastatic Niche" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:20 pm 
	
"Integrin-Mediated TGF-Beta Activation in Tumor Immune Evasion" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Cell-ECM Receptors in Cancer Cell Migration and Invasion 
 
 
 
						
9:00 am - 9:20 am 
	
"Mechanosensitive Actin Dynamics in Cancer Cell Invasion" 
 
 
 
						
9:20 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:50 am 
	
"Mechanosensing Governs Metabolism and Metastasis of Pancreatic Cancer" 
 
 
 
						
9:50 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Integrin a3ß1 Regulates the Tumor Cell Secretome to Promote a Pro-Tumorigenic Microenvironment" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:10 am 
	
"FAK and Extracellular Matrix – Making Connections in Ovarian Cancer" 
 
 
 
						
11:10 am - 11:20 am 
	
Discussion
 
 
						
11:20 am - 11:40 am 
	
"Extracellular Matrix Mechanics Regulates Stem Cell Fate by Altering Nuclear Architecture" 
 
 
 
						
11:40 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:00 pm 
	
"Mechanical Regulation of Mevalonate Pathway Enzyme Synthesis via Integrin and Rac1 Signaling" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:20 pm 
	
"Collective Amoeboid Migration: How to Move With Integrins but no Extracellular Matrix" 
 
 
 
						
12:20 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session: Fibronectin From Structure to Function 
 
 
 
						
7:30 pm - 8:10 pm 
	
"The Not-so-Simple Process of Fibronectin Matrix Assembly" 
 
 
 
						
8:10 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 8:30 pm 
	
"Tensin3 Interaction With Talin Drives the Formation of Fibronectin-Associated Fibrillar Adhesions" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 8:50 pm 
	
"Fibroblasts Deposit Membranous Tracks That Steer Cancer Cell Migration" 
 
 
 
						
8:50 pm - 9:00 pm 
	
Discussion
 
 
						
9:00 pm - 9:20 pm 
	
"Mechanosenssing and matrix homeostasis" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure