1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Cell-Matrix Interactions in Cancer
Siiri Salomaa (Altos Labs Cambridge Institute of Science, United Kingdom) and Jim Norman (Cancer Research UK - Beatson Institute, United Kingdom)
3:45 pm - 4:15 pm
Valerie Weaver (University of California, San Francisco, United States) "MechanoOncology and the Tumor Microenvironment"
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Cell-ECM Interactions Regulating Cell and Tissue Behavior
Gema Bolas Gonzalez-Lliberos (Vanderbilt Univ Medical Ctr (MCN), United States) and Guy Tanentzapf (University of British Columbia, Canada)
7:30 pm - 7:45 pm
Horacio Maldonado (University of Liverpool, United Kingdom) "A Trafficking Regulatory Sub-network Governs aVß6 Integrin-HER2 Crosstalk to Control Breast Cancer Invasion and Drug Resistance"
7:45 pm - 7:50 pm
7:50 pm - 8:05 pm
Nicole Mattson (City of Hope, United States) "Identification of a Lead Compound to Disrupt the Heterodimer Stability of ITGAV and ITGB5"
8:05 pm - 8:10 pm
8:10 pm - 8:25 pm
Andrew Miller (University of Virginia, United States) "Silencing of HOXA5 is a Novel Genomic Marker of THY-1 Negative Fibroblasts"
8:25 pm - 8:30 pm
8:30 pm - 8:45 pm
Fabian Bock (Vanderbilt University Medical Center, United States) "Rac1 Promotes Epithelial Collecting Duct Repair by Maintaining Mitotic Morphology"
8:45 pm - 8:50 pm
8:50 pm - 9:05 pm
Cassie Clarke (CRUK Beatson Institute, United Kingdom) "Uridine Phosphorylase 1, and its Product Uracil, Primes Metastatic Niches by Influencing Neutrophil Migration and Extracellular Matrix Deposition"
9:05 pm - 9:10 pm
9:10 pm - 9:25 pm
Megan Chastney (University of Turku, Finland) "SHANK3 in Integrin-Ras-actin Crosstalk in Cancer"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Molecular Mechanisms of Adhesion and Mechanosensing
Michalis Gounis (CRUK Beatson Institute, United Kingdom) and Sara Wickstrom (Max Planck Institute for Molecular Biomedicine, Germany)
9:00 am - 9:15 am
Emmanuel Dornier (Gustave Roussy institute, France) "Cell Clusters Adopt a Collective Amoeboid Mode of Migration in Confined Nonadhesive Environments"
9:15 am - 9:20 am
9:20 am - 9:35 am
Sarah Keary (ICFO - The Institute of Photonic Sciences, Spain) "Differential Activation and Mesoscale Organization of Integrin Nanoclusters in Focal Adhesions"
9:35 am - 9:40 am
9:40 am - 9:55 am
Kashish Jain (Mechanobiology Institute, National University of Singapore , Singapore) "Optimal Spacing Between Integrin Nanoclusters is Necessary for Mechanosensing and Mechanotransduction on Rigid Substrates"
9:55 am - 10:00 am
10:00 am - 10:15 am
Wenjun Deng (University of British Columbia, Canada) "Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development"
10:15 am - 10:20 am
10:20 am - 10:35 am
Thomas Zacharchenko (University of Manchester, United Kingdom) "New Insight into the Role of Talin-KANK1 Complexes in the Organization of Focal Adhesions"
10:35 am - 10:40 am
10:40 am - 10:55 am
Shashi Jain (Sanford Consortium for Regenerative Medicine, University of California San Diego, United States) "Cellular Stress Activates an Integrin avß3 Src/AMPK/PGC1a Signaling Axis to Promote Oxidative Phosphorylation and Stress Tolerance in Lung Cancer"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Regulation of ECM-Nucleus Mechnanosignaling
Ambra Pozzi (Vanderbilt University School of Medicine, United States) and Upnishad Sharma (ETH-Zürich, Switzerland)
1:30 pm - 2:00 pm
Pere Roca-Cusachs (Institute for Bioengineering of Catalonia, Spain) "Intermediate Filaments as Regulators of ECM-nucleus Mechanosignalling"
2:00 pm - 2:15 pm
2:15 pm - 2:30 pm
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)