Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Human Induced Pluripotent Stem Cells
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Using Stem Cells to Explore the Genetics Underlying Brain Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Preliminary Title: iPS Cell Reprogramming - From Basic Research to Clinical Trials"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms in Neurodevelopment
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"ADdressing the Genome Structure-Function Relationship in the Encoding and Forgetting of Memory"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Enhancing Evolution: Genetic Control of Human Brain Development"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Group Photo / Coffee Break
10:35 am - 10:50 am
"Using Single Nuclei Approaches to Dissect Motor Neuron Maturation in vivo and Generate More Adult-Like Motor Neurons from Stem Cells in Culture"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
"Identifying Epigenetic Changes Driving Global Molecular Dysregulation in Down Syndrome"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"FOS Binding Sites are a Hub for the Evolution of Activity-Dependent Gene Regulatory Programs in Human Neurons"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Combining Optical Electrophysiology, Pharmacology, and Optical Pooled CRISPR-Screens to Map Neuronal Genotype-Phenotype Relations"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Interpreting Neuropsychiatric Genetics through the Lens of Human Brain Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Generation of a Data-driven Single Cell and Spatial Transcriptomic Map of the Human Prefrontal Cortex and Application to Schizophrenia"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Bridging Transcriptomics and Network Activity in Neurodevelopmental Disorders"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Using CRISPRi to Investigate the Control of Human Neurodevelopment by a Group of Humanoid-Specific Transposons"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Spatial Relationships between Neuromelanin and Tau Accumulation with Local Gene Expression in the Human Locus Coeruleus"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Cellular Crosstalk in Neurodevelopmental Disorders"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Towards Scalable Pooled Optical Profiling of Sub-Cellular Proteome Organization"
10:25 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
"In Situ Mapping of Multimodal Phenotypes to Pooled Genetic Perturbations in Primary Cells and Tissue"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Novel Technology Linking Live-Imaging with Single-Cell Transcriptome Analysis of Functional Neuronal Networks on a Highly Parallel Scale"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Linking Genetics to Function
7:30 pm - 7:50 pm
"Genetic Basis of Pleiotropy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Dissecting the GeneticBasis of Schizophrenia Using Functional Genomics and Pluripotent Stem Cell Models"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Massively Parallel Characterization of Regulatory Elements in the Developing Human Cortex"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"A Neuronal Protein Network Model of Rare Risk Variants Unifies Genetic, Transcriptional, and Proteomic Perturbations in Schizophrenia"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modeling Responses to the Environment and Activity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Studying Environmental Impact on Neurodevelopment - From Cohort Studies to Cerebral Organoids"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Decoding Cellular and Molecular Deficits in Neurodevelopmental Disorders: Insights from Human Stem Cell-derived Neurons and Brain Organoids"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Using Human Brain Organoids to Understand Interindividual Response to Lithium in Patients"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Village-Based Neural Progenitor Cell Proliferation and Viability Assays Reveal Genetic and Environmental Determinants of Cellular Fitness"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"AB-Regulated Gene Circuits for Programmable Alzheimer’s Disease Therapy"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"SAME-NeuroID: Standardized Approaches to Modeling and Examination of Neuropsychiatric Disorders"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Cellular Methods and Tools
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Taming the Wild West: Standardisation of Pluripotent Stem Cells for Disease Modelling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Unraveling the Complexity: Biological Insights from Human Cellular Models of Psychiatric Disorders"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Enhancer-Targeted CRISPR Activation Rescues ASD Gene Expression and Phenotypes in Neurons & Cortical Organoids"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Interrogating the Mechanisms that Pattern Human Cortical Areas"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Viral Vectors for Targeted, Noninvasive Access to the Mammalian Brain - From Neuroscience Discovery to Treatments"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Identifying New Therapeutic Targets for ALS Using Rare Genetic Variants and CRISPR Technology"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Gene Therapy for Targeting a Prenatally Enriched Potassium Channel Associated with Severe Childhood Epilepsy and Premature Death"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"4R Tau Disrupts Molecular Networks, Including SALL1, Which Promotes Tau Aggregation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Modeling MT IVNS1ABP-Induced Neurodegeneration by Human iPSCs Derived Motor Neurons in a Newly Identified Progeria Syndrome"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Novel Single Cell CRISPR Screen Method in iPSC-Microglia Reveals Disease Risk Mechanisms at AD and MS Risk Loci and Nominates MAF as a Risk-Modifying, Pleiotropic Mediator of Microglial Activation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Poster Previews
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulatory and Ethical Guidelines for Clinical Translation
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Considerations for the Establishment of Cell Banks for Clinical Translation"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Guidelines for Stem Cell Research and Clinical Translation"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure