Sunday, July 20
2:00 PM - 8:00 PM Registration
6:00 PM - 7:00 PM Dinner
7:30 PM - Sunday Night - Opening Session
Chair: David Weiner
- Introduction to Conference: David Weiner
- Jon Norman, Vical - Improved Vectors for DNA Immunization: Adjuvant Effectors
- Richard Ciccarelli, Apollon - Bringing DNA Vaccines to the Clinic
- George R. Siber, Lederlie - How to establish serologic correlates of protection - lessons from bacterial vaccines
9:30 PM Cocktail Party Reception
Monday, July 21
7:30 AM - 8:30 AM Breakfast
8:00 AM - 11:00 PM Registration - Monday through Thursday
8:30 AM - Monday Morning Session
Chair: Barry Rouse
- Dennis Klinman, FDA, CBE - Autoimmunitity and Tolerance
- Heather Davis, Loeb Research Institute - Use of DNA as Adjuvant and Vaccine Against Hepatitis B
- Eyal Raz, UCSD - Gene Vaccination: The Role of Immunostimulatory DNA Sequences
10:15 AM - 10:45 AM Conference Photo and Break
- Arthur M. Krieg, U. of Iowa -Immune affects and CpG motifs
- Constantine Bona, Mt. Sinai School of Medicine - Cellular Mechanisms Involved in Immune Responses illicited by naked DNA Vaccines
12:30 PM - 1:30 PM Lunch
6:00 PM - 7:00 PM Dinner
7:30 PM - 9:30 PM - Monday Evening Session
Chair. Heather Davis
- Brian H. Barbar, Univ. of Toronto - DNA vaccines and Antigen Presentation
- David B. Weiner, University of Pennsylvania - Improving DNA vaccines
- Alan Gewertz, U. of Pennsylvania - Gene Delivery in Vivo- Lessons from Antisense ClinicaI Trials
Tuesday, July 22
7:30 AM - 8:30 AM Breakfast
8:30 AM - Tuesday Morning Session
Chair: Ronald C. Kennedy
- Michael A. Barry, Baylor College of Medicine - Manipulation of Immune Responses in Genetic Immunization
- Britta Wahren, Karolinska Institute - HIV Regulatory, Enzymatic and Structural Genes in Experimental and Human Vaccination
- Jean Boyer, U. of Pennsylvania - DNA Based Vaccine Induces HIV-1 Specific Responses in Primates.
10:00 AM Break
- Ronald C. Kennedy, U. of Oklahoma - Genetic lmmunization and Immune Responses in Simian Virus 40 Tomorigenic Models
- William V. Williams, U. of Pennsylvania - Variable Region DNA Vaccines
- R. Marty Conry, U. of Alabama at Birmingham - Clinical Trails of Polynucleotide Vaccines in Colon Cancer and Melanoma
12:30 PM - 1:30 PM Lunch
6:00 PM - 7:00 PM Dinner
7:30 PM - Tuesday Evening Session
Chair. Britta Wahren
- XiaoMoa Li, PMC Connaught - RSV vaccines- Protection against Primary Respiratory syncytial virus infection by DNA immunization
- Hildegund S. Ertl, Wistar Institute - Genetic lmmunology of Neonates
- Steven L. Hoffman, Naval Medical Research Inst. - DNA vaccines for Malaria
Wednesday, July 23
7:30 AM - 8:30 AM Breakfast
8:30 AM - Wednesday Morning Session
Chair: Douglas B. Lowrie
- David Bernstein, Cincinnatti Children's Hospital - Herpes Vaccine development
- Barry Rouse, U. of Tennessee - DNA Vaccines for Immunotherapy, as well as prophylaxis of Herpes
- Terry Higgins, Apollon - Facilitated DNA Vaccine for HSV-2
10:00 AM Break
- Theresa Banks, Chiron- DNA immunization against Herpes simplex virus; enhanced efficacy using a simbus virus base vector
- Douglas B. Lowrie, National Institute for Medical Research - DNA Vaccination against TB
- Jeffrey Ulmer, Merck - DNA Vaccine for TB
12:30 PM - 1:30 PM Lunch
4:00 PM POSTER SESSION
6:00 PM - 7:00 PM Dinner
7:30 PM - Wednesday Evening Session
Chair: Constantine Bona
- Joel Haynes, Heska - Veterinary Applications
- Susan Gould Folgerite, Biodelivery Sciences Inc. - Delivery of Genetic Vaccines by cochleates
- Joachim Schorr, Quiagen - Large Scale Pharmaceutical Manufacturing of Nucleic Acids for Human Gene Therapy and Genetic Vaccination Under Full cGMP Conditions
Thursday, July 24
7:30 AM - 8:30 AM Breakfast
8:30 AM - Thursday Morning Session
Chair: John Donneley
- Robert Whalen, CNRS - Cytotoxic and T-helper Lymphocyte Responses after DNA Immunization to the Hepatitis B Surface Antigen
- Alfred Prince, NY BIood Center - DNA/ALVAC Based Immunotherapy of Chronic HBV Infection
- Ranjit Ray, St. Louis Univ. - Hepatitis C virus Putative Core Protein: Cellular Gene Regulation and the Potential for Development of a Nucleic Acid Vaccine
10:00 AM Break
10:15 AM - Thursday Morning Session II
Chair: Rick Ciccarelli
- Jack R. Wands, MGH - Genetic Immunization for presistant viral Hepatitis
- John Donneley, Merck - DNA Vaccines for Influenza
- W. Ripley Ballou, Walter Reed Army Institute of Research - Development of Malarial Vaccines
12:30 PM - 1:30 PM Lunch
5:00 PM - 6:00 PM BUSINESS MEETING
6:00 PM - 7:00 PM Banquet
7:30 PM - Late Breaker Session
- Guido Dietrich, Univ. of Wurzburg - Delivery of Antigen-Encoding Plasmid DNA into the Cytosol of Macrophages by Attenuated Suicide Listeria Monocytogenes
- David M. Feltquate, Univ. of Massachusetts - Stimulatory CpG Sequences in Plasmid DNA Are Not Responsible for the TH1 Immune Response Generated by Intramuscular DNA Ionization
- William C. Heiser, Bio-Rad - New Developments in Gene Transfer Using the HeIios Gene Gun
- Geneviève Inchauspé, ISERM - Dissection of Humoral and Cellular Immune Responses following Direct Injection of Plasmid DNA Encoding Various HCV Antigens
- B. Rajendra Krishnan, Pfizer - Immunogenecity and Vaccine Potential of the Heat Shock Protein Nucleic Acid Sequences of Leptospira
- Marie-Louise Michel, Pasteur Institute - In vivo Induction of Specific Cytotoxic T Lymphocytes in Mice and Rhesus Macaques immunized with DNA Vaccines Encoding an HIV epitope Fused with HBsAg
- Juha Punnonen, Maxygen, Inc - Evolution of DNA Vaccine Vectors by Gene Shuffling
- William F. Swain, Geniva - Particle-mediated Nucleic Acid Vaccination against Hepatitis B Virus
Friday, July 25
7:30 AM - 8:30 AM Breakfast
9:00 AM Bus Leaving for Logan Airport
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