Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Sphingolipids and Glycosphingolipids in Cell Biology and Disease
Session in memory of Lina Obeid.
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:30 pm
"Sphingosine-1-Phosphate: From Bench to Clinic"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Glycosphingolipids in Neuronal Homeostasis and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Measuring and Manipulating Sphingolipids and Glycosphingolipids: Challenges and Solutions
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Chromatography & Mass Spectrometry: Why There Is No All-in-One Solution For Sphingolipidomics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Fluorescence Methods to Investigate the Biophysical Properties of Sphingolipids"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Optical Control of Membrane Fluidity Modulates Protein Secretion"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Ca2+-Activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-Independent Lysosomal Repair"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Sphingolipids Control Dermal Fibroblast Heterogeneity"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Interrogating Ceramide Synthase Contribution to Functionalization of Membrane Proteins ABCB1 and Megalin in the Kidney"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ceramide Biology and Pathophysiology
6:00 pm - 6:20 pm
"Pathogenic Mutations in Serine Palmitoyltransferase Cause Multiple Neurodegenerative Diseases"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Structure-Function Analysis of Ceramide Synthases"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Physical Properties of Ceramides and Their Pathophysiological Correlations"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Avenues for Boosting Therapeutic Potential of the 'Ceramide Effect'"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sphingosine and Sphingosine-1-Phosphate Biology and Pathophysiology
9:00 am - 9:20 am
"The Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Interaction of Wnt and S1P Signaling Regulates Brain Angiogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Sphingosine Exits Lysosomes via Known Cholesterol Transporters NPC1 and LIMP2"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Sphingosine 1-phosphate Signaling in Systemic Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"S1P Receptor-1 Signaling at the Blood-Brain Barrier"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"S1P-Lyase Deficiency in the Brain Increases Glucose Breakdown Evoking a P2Y1 Receptor-Dependent Astrogliosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Effects of Gut-Specific S1P Lyase Deficiency on the Intestinal Transcriptome and Microbiome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycosphingolipids: Biosynthesis, Function and Disease
6:00 pm - 6:20 pm
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Identifying New Players in Krabbe Disease: How Galactosphingolipids Alter Membrane Protein Abundance"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Gene Therapy for GM1 Gangliosidosis: A Ten-Year Odyssey"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Glycosphingolipid-Protein Interactions and Renoprotective Mechanisms of Globo-Series Glycosphingolipid Depletion"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Generation and Examination of Glycosphingolipid-Depleted Human iPSCs and Their Derivatives"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sphingolipids and Glycosphingolipids as Modulators of Membrane Function
9:00 am - 9:20 am
"Imaging the Cholesterol and Sphingolipid Abundance at the Site of Influenza Virus Assembly"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Different Approaches to Study the Role of Membrane Gangliosides in Modulating Cell Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Biophysical Lessons Learned from the Ceramide Nanoliposome Clinical Trial"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
"GM1 Oligosaccharide Membrane Signalling: The Switch to Turn on a Neuroprotective Program Acting via Mitochondria Modulation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Role of ß-glucocerebrosidase Deficiency in the Onset of Neuronal Degeneration: New Findings on the Involvement of a Lysosome-Plasma Membrane Axis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Short Fatty Acid Chain Sulfatides are Endogenous Ligands for TLR4/MD-2"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Cell Growth and Differentiation
6:00 pm - 6:20 pm
"Organellar Membrane Contact Sites in the Synaptogenesis and Synaptopathy of GM1-Gangliosidosis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Ceramide-Enriched Exosomes in Alzheimer's Disease: Role in Pathophysiology and Novel Pharmacological Target"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Endothelial Cell Apoptosis Determines Intestinal Stem Cell Fate"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Sphingolipids Orchestrating the Cross-Talk Between Different Cell Populations in the Repair of Damaged Myelin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"A Novel Mechanism in Sphingolipid-Mediated Phosphoinositide Homeostasis at Trans-Golgi Network"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Multifaceted Roles of Sphingolipids in Microbial Infection"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Glucocerebrosidase and Brain Disease: Novel Functions Beyond the Lysosome"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Oral L-serine Prevents Taxane-Induced Neuropathic Behaviors in Mice"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Glucosylceramide as Precursor of Glucosylsphingosine and Glucolites"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Hepatic Ceramide Accumulation During Fatty Liver Disease Requires Active Neutral Sphingomyelinase-2 and Drives Insulin Resistance"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Pathogenic Variants of SMS2 Disrupt Lipid Landscapes in the Secretory Pathway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Sphingolipids and Glycosphingolipids in Non-Mammalian Systems
6:00 pm - 6:20 pm
"Ceramide Chain Length-Dependent Protein Sorting Into Selective Endoplasmic Reticulum Exit Sites "
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Bacterial Sphingolipids Mediate Host-Microbiome Interactions in the Intestine"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Discovery of Cryptic Bacterial Sphingolipids Reveals a Convergent Evolutionary Biosynthetic Pathway"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Multiple Biophysical Approaches To Study the Role of Plant Sphingolipids GIPC in Plasma Membrane Organization"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure